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The patient and clinician perspective on 'early' bowel resection for terminal ileal Crohn's disease (EBRIC): protocol for a multicentre mixed-methods study
Publication Year: 2025 Source: Colorectal Dis PMID: 40025798
AIM: Emerging evidence supports the consideration of surgery earlier in the treatment pathway for isolated luminal terminal ileal (TI) Crohn's disease (CD), as an alternative to medical therapy. Surgery is still considered late in the treatment pathway; recruiting participants into trials comparing medical therapy and surgery is difficult. This will …
Clinical features by disease duration in ulcerative colitis-associated cancers
Publication Year: 2025 Source: Colorectal Dis PMID: 40025818
AIM: Ulcerative colitis (UC) is a known contributor to the development of colitis-associated cancer (CAC), although the exact mechanism remains to be elucidated. CAC typically presents as a flat type macroscopically and manifests histologically as mucinous carcinoma and signet ring cell carcinoma. While the relationship between disease duration and chronic …
Patient Reported Outcomes in Primary Sclerosing Cholangitis: An Australian Perspective
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40025830 DOI: 10.1111/apt.70054
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a rare, cholestatic liver condition that has a significant association with inflammatory bowel disease (IBD) and impaired health-related quality of life (HRQOL). We aimed to characterise and compare validated PSC and IBD patient-reported outcomes (PRO) and determine if PRO correlated with the …
Guidelines for endoscopic diagnosis and treatment of inflammatory bowel diseases
Publication Year: 2025 Source: Dig Endosc PMID: 40025935
In recent years, we have seen a considerable increase in the number of patients with inflammatory bowel diseases of unknown etiology, including both Crohn's disease and ulcerative colitis. Inflammatory bowel diseases can cause intestinal lesions throughout the gastrointestinal tract, necessitating gastrointestinal endoscopy for examining all relevant aspects, especially lesion characteristics, …
Intestinal Microbiota Contributes to the Development of Cardiovascular Inflammation and Vasculitis in Mice
Publication Year: 2025 Source: Circ Res PMID: 40026151
BACKGROUND: Alterations in the intestinal microbiota contribute to the pathogenesis of various cardiovascular disorders, but how they affect the development of Kawasaki disease (KD) an acute pediatric vasculitis, remains unclear. METHODS: We used the Lactobacillus casei cell wall extract (LCWE) murine model of KD vasculitis to assess the contribution of …
Biomarker discovery in psoriatic disease
Publication Year: 2025 Source: Curr Opin Rheumatol PMID: 40026206
PURPOSE OF REVIEW: Psoriasis, a chronic skin condition, characterized by scaly erythematous plaques, is prevalent in around 2% of the population. Around 25% of psoriasis patients have psoriatic arthritis (PsA), an inflammatory musculoskeletal disease that often leads to progressive joint damage and disability. Psoriatic diseases (PsD) encompassing psoriasis and PsA, …
Advanced Combination Therapy with Biologics and Upadacitinib in Refractory Inflammatory Bowel Disease: A Retrospective Study from Taiwan
Publication Year: 2025 Source: J Inflamm Res PMID: 40026313 DOI: 10.2147/JIR.S511309
BACKGROUND: Refractory inflammatory bowel disease (IBD) remains challenging despite the availability of various biologics. Advanced combination therapy (ACT) with biologics and Upadacitinib (UPA), a rapid-onset oral selective Janus kinase inhibitor, has shown promise in managing refractory IBD. However, its use in Asia has not been explored. This study aims to …
Conditioned medium derived from mesenchymal stem cells and spinal cord injury: A review of the current therapeutic capacities
Publication Year: 2025 Source: IBRO Neurosci Rep PMID: 40026846
Spinal cord injury (SCI) is a debilitating condition of the nervous system that imposes considerable challenges for subjects, such as bladder and bowel incontinence and infections. The standard therapeutic strategy is methylprednisolone utilization accompanied by surgical decompression. However, achieving an effective therapy with the minimum side effects for SCI is …
Mesalazine-Induced Myocarditis in Inflammatory Bowel Disease: A Systematic Review
Publication Year: 2025 Source: Cureus PMID: 40027008 DOI: 10.7759/cureus.78208
Crohn's disease (CD) and ulcerative colitis (UC) are two forms of inflammatory bowel disease (IBD). This chronic, immune-mediated disorder leads to inflammation in specific gastrointestinal tract regions. Myocarditis is a rare but significant IBD complication that affects roughly 0.3% of cases. Mesalazine-induced myocarditis is a rare side effect of mesalazine …
Mental Health Disorders in Patients with Inflammatory Bowel Disease Onset in Childhood or Youth - A Nationwide Cohort Study from Denmark
Publication Year: 2025 Source: Clin Epidemiol PMID: 40027400 DOI: 10.2147/CLEP.S491881
PURPOSE: The study aims to explore the association between patients diagnosed with inflammatory bowel disease (IBD) in childhood or youth and mental health disorders. METHODS: The study is a register-based cohort study of patients with IBD-onset before 25 years of age and matched references. They were followed until 30 years …
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