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Cohort Update: ESPRESSO (Epidemiology Strengthened by Histopathology Reports in Sweden)
Publication Year: 2025 Source: Clin Epidemiol PMID: 40027403 DOI: 10.2147/CLEP.S499859
No Abstract
Linking dietary fiber to human malady through cumulative profiling of microbiota disturbance
Publication Year: 2025 Source: Imeta PMID: 40027480
Dietary fiber influences the composition and metabolic activity of microbial communities, impacting disease development. Current understanding of the intricate fiber-microbe-disease tripartite relationship remains fragmented and elusive, urging a systematic investigation. Here, we focused on microbiota disturbance as a robust index to mitigate various confounding factors and developed the Bio-taxonomic Hierarchy …
Development of a Transcriptional Biosensor for Hydrogen Sulfide that Functions under Aerobic and Anaerobic Conditions
Publication Year: 2025 Source: bioRxiv PMID: 40027654 DOI: 10.1101/2025.02.19.639182
Hydrogen sulfide (H(2)S) is a gaseous gut metabolite with disputed effects on gastrointestinal health. Monitoring H(2)S concentration in the gut would provide insight into its role in disease, but is complicated by sulfide's reactivity and volatility. Here we develop a transcriptional sulfide biosensor in E. coli. The sensor relies on …
Patchoulene epoxide mitigates colitis and hepatic damage induced by dextran sulfate sodium by regulating the colonic microbiota and purine metabolism
Publication Year: 2025 Source: Front Immunol PMID: 40028318
INTRODUCTION: Ulcerative colitis (UC) is often characterized by dysbiosis of the colonic microbiota and metabolic disturbances, which can lead to liver damage. Patchoulene epoxide (PAO), a tricyclic sesquiterpene derived from the aged essential oil of Pogostemonis Herba, is known for its anti-inflammatory and ulcer-healing properties. However, its dual protective role …
Research trends of inflammation in autism spectrum disorders: a bibliometric analysis
Publication Year: 2025 Source: Front Immunol PMID: 40028326
BACKGROUND: Inflammation has been recognized as a significant factor in the pathophysiology of autism spectrum disorders (ASD), which have garnered increasing scholarly attention over the past few decades. This study aims to explore research trends related to inflammation and ASD through bibliometric analysis. METHOD: A comprehensive literature search was conducted …
Potential predictors of efficacy outcomes following tofacitinib dose reduction in patients with ulcerative colitis in stable remission: a post hoc analysis of outcomes from the RIVETING study
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40028509
BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor for the treatment of ulcerative colitis (UC). OBJECTIVES: To investigate potential predictors of efficacy in RIVETING. DESIGN: This post hoc analysis included patients with UC in stable remission (⩾6 months) on tofacitinib 10 mg twice daily (BID) maintenance therapy (⩾2 years of …
A Spotlight on Archaea in Humans, Livestock and Poultry: A Review
Publication Year: 2025 Source: Vet Med Sci PMID: 40028749 DOI: 10.1002/vms3.70263
The microbiota includes prokaryotes (archaea and bacteria) and eukaryotes. Archaea are single-celled prokaryotes and essential part of gut microbiome. Researches on archaea in ruminants and humans are more than mono-gastric. The low abundance of archaea in the gut depends on the method used (metagenomics or meta-transcriptomic) and age of people …
Sodium butyrate alleviates DSS-induced inflammatory bowel disease by inhibiting ferroptosis and modulating ERK/STAT3 signaling and intestinal flora
Publication Year: 2025 Source: Ann Med PMID: 40028886 DOI: 10.1080/07853890.2025.2470958
BACKGROUND: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), can seriously impact patients' quality of life. Sodium butyrate (NaB), a product of dietary fiber fermentation, has been shown to alleviate IBD symptoms. Some studies have shown that it is related to ferroptosis. However, the precise mechanism …
Mutational Analysis of Bile Cell-Free DNA in Primary Sclerosing Cholangitis: A Pilot Study
Publication Year: 2025 Source: Liver Int PMID: 40029142
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic liver disease characterised by inflammation and fibrosis of the bile ducts, conferring an increased risk of cholangiocarcinoma (CCA). However, detecting CCA early in PSC patients remains challenging due to the limited sensitivity of conventional diagnostic methods, including imaging or bile duct brush …
Multicompartmental Hydrogel Microspheres with a Concentric Thin Oil Layer: Protecting and Targeting Therapeutic Agents for Inflammatory Bowel Disease
Publication Year: 2025 Source: ACS Appl Bio Mater PMID: 40030207 DOI: 10.1021/acsabm.4c01763
Although oral delivery of therapeutic agents offers numerous benefits, its application is limited due to the digestive tract's harsh conditions (e.g., strong acidity and high osmolarity), which impair activity and create challenges in achieving targeted release into the intestine. Here, we present multicompartmental hydrogel microspheres equipped with a concentric oil …
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