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Why is ultrasound needed in inflammatory bowel disease?
Publication Year: 2025 Source: Med Ultrason PMID: 40030691 DOI: 10.11152/mu-4492
Intestinal ultrasound had been performed in several countries for more than 30 years, but for a longer period had been inthe hands of few experts. With new evidence showing that the method is accurate and has excellent performance especially intreatment monitoring and detection of complications of IBD, there is a …
The dual missions of FoxO3a in inflammatory diseases: Regulation of antioxidant enzymes and involvement in programmed cell death
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40031428
The transcription factor FoxO3a plays a crucial role in the process of cells adapting to various stress conditions. Multiple post - translational modifications and epigenetic mechanisms work together to precisely regulate the activity of FoxO3a, influencing its subcellular localization, stability, interactions with other proteins, DNA - binding affinity, and transcriptional …
Quantification of All-Trans Retinoic Acid and Cytokine Levels After Fungal, Viral and Bacterial Infections in the Lung
Publication Year: 2025 Source: J Cell Mol Med PMID: 40031928
All-trans retinoic acid (atRA) plays a critical role in tissue homeostasis as a master regulator of cellular proliferation, apoptosis and differentiation as well as in immune cell differentiation and function. An active metabolite of vitamin A, atRA has been reported to be reduced in a number of inflammatory conditions in …
[Nodakenin ameliorates TNBS-induced experimental colitis in mice by inhibiting pyroptosis of intestinal epithelial cells]
Publication Year: 2025 Source: Nan Fang Yi Ke Da Xue Xue Bao PMID: 40031970
OBJECTIVES: To investigate the therapeutic mechanism of nodakenin for Crohn's disease (CD)-like colitis in mice. METHODS: Using a colonic organoid model with lipopolysaccharide (LPS)- and ATP-induced pyroptosis, we investigated the effects of nodakenin on pyroptosis, intestinal barrier function and inflammatory response by detecting key pyroptosis-regulating factors and assessing changes in …
Oral Lipid-Based Nanomedicine for the Inhibition of the cGAS-STING Pathway in Inflammatory Bowel Disease Treatment
Publication Year: 2025 Source: Mol Pharm PMID: 40032274 DOI: 10.1021/acs.molpharmaceut.4c01297
Harnessing the effect of the cyclic GMP-AMP Synthase-STimulator of INterferon Genes (cGAS-STING) signaling pathway has emerged as a promising approach to developing novel strategies for the oral treatment of inflammatory bowel disease (IBD). In this work, we screened different cGAS-STING inhibitors in vitro in murine macrophages. Then, we encapsulated the …
24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting T(H)17 pathogenicity and transdifferentiation
Publication Year: 2025 Source: Gut PMID: 40032499
BACKGROUND: 24-Nor-ursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for treating immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC). OBJECTIVE: Since PSC strongly associates with T helper-type-like 17 (T(H)17)-mediated intestinal inflammation, we explored NorUDCA's immunomodulatory potential on T(H)17 cells. DESIGN: NorUDCA's impact on T(H)17 differentiation was assessed …
Microbiota-derived metabolites in inflammatory bowel disease
Publication Year: 2025 Source: Semin Immunopathol PMID: 40032666 DOI: 10.1007/s00281-025-01046-9
Understanding the role of the gut microbiota in the pathogenesis of inflammatory bowel diseases (IBD) has been an area of intense research over the past decades. Patients with IBD exhibit alterations in their microbial composition compared to healthy controls. However, studies focusing solely on taxonomic analyses have struggled to deliver …
[Fibrotic diseases in the gastrointestinal tract : Liver fibrosis and more]
Publication Year: 2025 Source: Inn Med (Heidelb) PMID: 40032677
Chronic liver damage, such as metabolic dysfunction-associated steatotic liver disease (MASLD), viral hepatitis B or C, cholestatic hepatitis (PBC, PSC), toxic damage (alcohol) or genetic alterations (hemochromatosis, Wilson's disease, etc.) usually cause a chronic inflammatory response in liver cells or bile duct epithelial cells. In the long term this chronic …
AI-enabled 'endo-histo-omics': breaking down intestinal barriers in IBD
Publication Year: 2025 Source: Nat Rev Gastroenterol Hepatol PMID: 40033062 DOI: 10.1038/s41575-025-01051-1
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Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis
Publication Year: 2025 Source: Nat Immunol PMID: 40033120 DOI: 10.1038/s41590-025-02081-2
Neuronal signals have emerged as critical factors that regulate group 3 innate lymphoid cell (ILC3) response and tissue homeostasis, but the molecular mechanisms underlying this regulation remain largely elusive. Here, we identified that the enteric GABAergic neuron-derived neurotransmitter gamma-aminobutyric acid (GABA) inhibited proliferation and IL-17A production in ILC3s in a …
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