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Higher-Dose Infliximab Induction Achieves Better Maintenance Trough Levels in a National Pediatric IBD Cohort-A Retrospective Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40036162
BACKGROUND: Proactive drug monitoring in our national cohort of children with inflammatory bowel disease suggested that 5 mg/kg dosing of infliximab (IFX) was associated with inadequate trough levels (TLs), thus we commenced empiric 10 mg/kg dosing in 2019. METHODS: This was a retrospective study of patients commenced on 5 or …
Efficacy and Safety of Etrasimod in Patients With Moderately to Severely Active Ulcerative Colitis Stratified by Baseline Modified Mayo Score: A Post Hoc Analysis From the Phase 3 ELEVATE UC Clinical Program
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40036804 DOI: 10.1093/ibd/izaf036
BACKGROUND: Etrasimod is an oral, once daily, selective sphingosine 1-phosphate (S1P)1,4,5 receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). This post hoc analysis of the ELEVATE UC clinical program describes etrasimod efficacy and safety by patients' baseline disease activity. METHODS: Predefined efficacy endpoints were assessed …
Intestinal ultrasound as a prognostic tool in new-onset ulcerative colitis-a Copenhagen IBD Cohort Study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40036961
BACKGROUND AND AIMS: This study assesses the prognostic role of intestinal ultrasound (IUS) in determining the disease course of ulcerative colitis (UC) in the first year after diagnosis. METHODS: A prospective, multicenter population-based inception cohort study was conducted on patients newly diagnosed with UC. Patients with left-sided or extensive UC …
Evaluating changes in attractor sets under small network perturbations to infer reliable microbial interaction networks from abundance patterns
Publication Year: 2025 Source: Bioinformatics PMID: 40036964 DOI: 10.1093/bioinformatics/btaf095
MOTIVATION: Inferring microbial interaction networks from microbiome data is a core task of computational ecology. An avenue of research to create reliable inference methods is based on a stylized view of microbiome data, starting from the assumption that the presences and absences of microbiomes, rather than the quantitative abundances, are …
Polysaccharide from Pyrus pashia Buch ameliorates DSS-induced colitis in mice via MAPKP38/NF-κB P65 and SCFAs/ERK/MSK signaling pathways
Publication Year: 2025 Source: Phytomedicine PMID: 40036991
PURPOSE: In this experiment, we investigated the effect of Pyrus pashia Buch on the relevant inflammatory disease indexes, intestinal microbiota, and short-chain fatty acids in mice with dextran sodium sulfate (DSS)-induced ulcerative colitis. METHODS: The anti-inflammatory effect of PPBP was assessed by measuring inflammatory markers (ELISA), colonic pathological changes (H&E), …
Modulation of occludin, NF-κB, p-STAT3, and Th17 response by DJ-X-025 decreases inflammation and ameliorates experimental colitis
Publication Year: 2025 Source: Biomed Pharmacother PMID: 40036995 DOI: 10.1016/j.biopha.2025.117939
SCOPE: Inflammatory bowel disease (IBD) involves a range of immune-mediated disorders marked by systemic and local intestinal inflammation. We synthesized a novel compound DJ-X-025 and uncovered its anti-inflammatory properties using lipopolysaccharide (LPS)-induced RAW 264.7 macrophages in vitro and a dextran sodium sulfate (DSS)-induced model of colitis. METHODS AND RESULTS: We …
Anti-inflammatory agents design via the fragment hybrid strategy in the discovery of compound c1 for treating ALI and UC
Publication Year: 2025 Source: Eur J Med Chem PMID: 40037062
Acute lung injury (ALI) and ulcerative colitis (UC) are common inflammatory diseases with high mortality rates and unsatisfactory cure rates. Studies have indicated that inhibiting the expression and release of inflammatory factors holds potential for the treatment of inflammatory diseases. In this study, we designed and synthesized 28 derivatives of …
Iron-lead mixed exposure causes bone damage in mice: A multi-omics analysis
Publication Year: 2025 Source: Ecotoxicol Environ Saf PMID: 40037083 DOI: 10.1016/j.ecoenv.2025.117967
Excessive intake of essential and toxic metals affects the pathological process of osteoporosis. At present, the effects of single forms of iron (Fe), lead (Pb) and other metals on bone injury have been widely studied. However, these metal elements usually do not exist in the environment in a separate form. …
Nanozyme-functionalized microalgal biohybrid microrobots in inflammatory bowel disease treatment
Publication Year: 2025 Source: Biomaterials PMID: 40037206 DOI: 10.1016/j.biomaterials.2025.123231
Oral drugs are the most direct and effective strategy for the treatment of gastrointestinal diseases. However, the harsh environment of gastric juice, lack of targeted lesion sites, and rapid metabolism present difficulties in the development of oral drugs. This research introduces a nanozyme-functionalized microalgal biohybrid microrobot (Hp@CS-PNAs@PAA) with a novel …
Independent predictors of 90-day readmission in patients with inflammatory bowel disease: a nationwide retrospective study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40037290 DOI: 10.1093/ecco-jcc/jjaf034
BACKGROUND AND AIMS: There is a paucity of literature that comprehensively investigates risk factors for inflammatory bowel disease (IBD) readmissions on a national scale. In this study, we look to identify independent risk factors for readmission, including psychosocial factors, in patients admitted with a primary diagnosis of ulcerative colitis (UC) …
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