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JAK inhibitor ameliorates inflammatory bowel disease in a patient with IKZF1 haploinsufficiency
Publication Year: 2025 Source: Clin Immunol PMID: 40037506 DOI: 10.1016/j.clim.2025.110470
IKAROS, encoded by IKZF1, is a crucial transcription factor regulating hematopoiesis and B cell development. While IKZF1 haploinsufficiency variants are associated with various immunological disorders, inflammatory bowel disease (IBD) has been rarely reported. We report a case of IKZF1 haploinsufficiency presenting with an atypical IBD phenotype and its response to …
Dietary Nut and Legume Intake and Risk of Crohn's Disease and Ulcerative Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40037780 DOI: 10.1093/ibd/izaf032
BACKGROUND: We investigated the relationship between nut and legume intake and risk of Crohn's disease (CD) and ulcerative colitis (UC). METHODS: We conducted a prospective cohort study of 223 283 adults from the Nurses' Health Study (NHS), NHSII, and Health Professionals Follow-Up Study (1986-2017), excluding those with inflammatory bowel disease …
Major adverse cardiovascular, thromboembolic and malignancy events in the filgotinib rheumatoid arthritis and ulcerative colitis clinical development programmes
Publication Year: 2025 Source: RMD Open PMID: 40037922
OBJECTIVES: Long-term safety is fundamental for treatment decision-making. This integrated analysis of filgotinib clinical trials in rheumatoid arthritis (RA) and ulcerative colitis (UC) assessed adverse events of interest (AEI): major adverse cardiovascular events (MACE), venous thromboembolism (VTE) and malignancies. METHODS: Data were integrated from all phase II and III trials …
Chloride channels and mast cell function: pioneering new frontiers in IBD therapy
Publication Year: 2025 Source: Mol Cell Biochem PMID: 40038149 DOI: 10.1007/s11010-025-05243-w
Emerging evidence indicates that chloride channels (ClCs) significantly affect the pathogenesis of inflammatory bowel disease (IBD) through their regulatory roles in mast cell function and epithelial integrity. IBD, encompassing conditions such as Crohn's disease and ulcerative colitis, involves chronic inflammation of the gastrointestinal tract, where channels influence immune responses, fluid …
Clinical characterization of aortitis and periaortitis: study of 134 patients from a single university hospital
Publication Year: 2025 Source: Intern Emerg Med PMID: 40038164
Aortitis and periaortitis refer to the inflammation of the aortic wall and the surrounding tissues. Both conditions are associated with various diseases and express nonspecific manifestations. Early diagnosis and treatment are crucial to improve the prognosis of the disease. This study aimed to assess the causes and main clinical features …
Fecal Microbiota Transplantation (FMT) and Clinical Outcomes Among Inflammatory Bowel Disease (IBD) Patients: An Umbrella Review
Publication Year: 2025 Source: Dig Dis Sci PMID: 40038211 DOI: 10.1007/s10620-025-08946-8
BACKGROUND AND AIMS: Recent systematic reviews and meta-analyses (SRMAs) have shown inconsistent effectiveness of FMT among patients with IBD. This study aimed to appraise the evidence for clinically relevant outcomes with FMT in patients with IBD using published SRMAs. METHODS: We searched major databases from inception through Nov 2023 to …
RNA cytidine acetyltransferase NAT10 maintains T cell pathogenicity in inflammatory bowel disease
Publication Year: 2025 Source: Cell Discov PMID: 40038243 DOI: 10.1038/s41421-025-00781-5
The emerging field of epitranscriptomics is reshaping our understanding of post-transcriptional gene regulation in inflammatory diseases. N(4)-acetylcytidine (ac(4)C), the only known acetylation modification in RNA catalyzed by N-acetyltransferase 10 (NAT10), is known to enhance mRNA stability and translation, yet its role in inflammatory bowel disease (IBD) remains unclear. In this …
Investigating the expression of anti/pro-inflammatory cytokines in the pathogenesis and treatment of ulcerative colitis and its association with serum level of vitamin D
Publication Year: 2025 Source: Sci Rep PMID: 40038357
Ulcerative colitis is an idiopathic gastrointestinal disease described by chronic inflammation of the digestive system. Cytokines may be responsible for immunopathogenesis, mucosal and tissue damage, and even treatment response. In addition to its role in calcium and phosphorus homeostasis and bone health, vitamin D is an immunomodulatory and anti-inflammatory agent. …
Characteristics and long-term outcomes of children with perianal Crohn's disease
Publication Year: 2025 Source: Intest Res PMID: 40038553
BACKGROUND/AIMS: The incidence of perianal lesions (PL) in children with Crohn's disease (CD) is higher in East Asia than in Western countries. Early intervention for PL is essential to prevent sphincter dysfunction and ostomy placement. In this study, we aimed to investigate the clinical features, treatment, and consequences of pediatric …
The causal impact of genetically predicted inflammatory bowel disease on extraintestinal manifestations: a mendelian randomization study
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40038580 DOI: 10.1186/s12876-024-03566-4
BACKGROUND: Extraintestinal manifestations (EIMs) significantly affect the life quality of people with inflammatory bowel disease (IBD) and are crucial factors impacting occurrence rates and mortality among IBD patients. This study performed a Mendelian randomization (MR) analysis to investigate the causal relationships between genetically predicted IBD and the development of EIMs, …
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