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Effectiveness and Safety of Upadacitinib Induction Therapy for 223 Patients With Crohn's Disease: A GETAID Multicentre Cohort Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40038887
BACKGROUND: Real-world effectiveness and safety of upadacitinib in patients with Crohn's disease (CD) remain unclear. AIMS: This study aimed to evaluate the effectiveness and safety of upadacitinib in a real-world cohort. METHODS: From September 2022 to June 2024, all consecutive patients with refractory luminal CD treated with once daily upadacitinib …
The role of miRNAs in the pathogenesis, diagnosis, and treatment of colorectal cancer and colitis-associated cancer
Publication Year: 2025 Source: Clin Exp Med PMID: 40091000 DOI: 10.1007/s10238-025-01582-6
MicroRNAs (miRNAs) are a group of noncoding single-stranded RNA biomolecules that act in posttranscriptional regulation of gene expression. Their role in the development of inflammatory bowel disease (IBD), colitis-associated cancer (CAC), and colorectal cancer (CRC) is currently under investigation. A few miRNAs present promising results in terms of diagnostic or …
Long-Term Effectiveness and Safety of Ustekinumab Dose Escalation in Patients with Moderate-to-Severe Ulcerative Colitis: A Multicenter Retrospective Cohort Study
Publication Year: 2025 Source: Dig Dis Sci PMID: 40091002
BACKGROUND: Ustekinumab dose escalation (DE) may be an effective strategy to recapture clinical response in patients with ulcerative colitis (UC). The aim of this study was to assess the real-world long-term effectiveness and safety outcomes following ustekinumab DE in patients with moderate-to-severe UC. METHODS: This multicenter retrospective cohort study included …
Leucine-rich Alpha-2 glycoprotein could be clinically useful in active and postoperative Crohn's disease
Publication Year: 2025 Source: Sci Rep PMID: 40091130
The clinical usefulness of serum leucine-rich alpha-2 glycoprotein (LRG) levels as a surrogate marker of endoscopic activity including postoperative recurrence in patients with Crohn's disease (CD) remains unclear, and LRG production in the small intestinal mucosa has not been explored. The present study investigated the usefulness of serum LRG to …
Neuroinflammation in Adaptive Immunodeficient Mice with Colitis-like Symptoms
Publication Year: 2025 Source: Exp Neurobiol PMID: 40091637 DOI: 10.5607/en24016
Emerging evidence suggests that systemic inflammation may play a critical role in neurological disorders. Recent studies have shown the connection between inflammatory bowel diseases (IBD) and neurological disorders, revealing a bidirectional relationship through the gut-brain axis. Immunotherapies, such as Treg cells infusion, have been proposed for IBD. However, the role …
Impact of Clostridioides difficile Infection on Clinical Outcomes in Hospitalized IBD Patients and the Role of Fecal Microbiota Transplantation: A Retrospective Cohort Study
Publication Year: 2025 Source: Kaohsiung J Med Sci PMID: 40091757 DOI: 10.1002/kjm2.70002
Clostridioides difficile infection (CDI) worsens the prognosis of patients with inflammatory bowel disease (IBD). This retrospective cohort study aimed to evaluate the risk factors, clinical manifestations, and outcomes of CDI in hospitalized patients with IBD, including those with toxin A/B results between April 2007 and April 2021. Patients were classified …
Engineered Probiotics Enable Targeted Gut Delivery of Dual Gasotransmitters for Inflammatory Bowel Disease Therapy
Publication Year: 2025 Source: Angew Chem Int Ed Engl PMID: 40091878 DOI: 10.1002/anie.202502588
Inflammatory bowel disease (IBD) remains an incurable condition, often accompanied by high rates of anxiety and depression, further diminishing the quality of life of patients. Endogenous gasotransmitters, such as carbon monoxide (CO) and hydrogen sulfide (H(2)S), exhibit potent anti-inflammatory and immunomodulatory effects. However, their therapeutic application is limited by challenges …
Spilled but Not Forgotten: A Retained Gallstone Leading to Colonic Fistula Formation
Publication Year: 2025 Source: Cureus PMID: 40091906
Laparoscopic cholecystectomy (LC) is a routinely performed procedure for symptomatic cholelithiasis, known for its minimal invasiveness and favorable outcomes; however, intraoperative gallbladder perforation and subsequent stone spillage can lead to rare but serious complications such as abscess formation and fistulization. A 38-year-old male patient with a history of sickle cell …
Unseen toxins: Exploring the human health consequences of micro and nanoplastics
Publication Year: 2025 Source: Toxicol Rep PMID: 40092045 DOI: 10.1016/j.toxrep.2025.101955
No Abstract
Exploring the bioactive properties and mechanism of Aegle marmelos in the treatment of inflammatory bowel disease through network pharmacology and a molecular docking approach
Publication Year: 2025 Source: Am J Transl Res PMID: 40092097 DOI: 10.62347/GCCV5213
BACKGROUND: Inflammatory bowel diseases (IBD) are recurrent inflammatory conditions that occur in the gastrointestinal tract, for which current treatment does not have satisfactory results, thus we require new therapies to combat the complex pathogenesis of IBD. Herbal medicines have been used for years to cure IBD. One of the plants …
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