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Healthcare Providers' Perspectives on Anoreceptive Intercourse in Sexual and Gender Minorities With Ileal Pouch Anal Anastomosis
Publication Year: 2025 Source: Clin Transl Gastroenterol PMID: 40099770 DOI: 10.14309/ctg.0000000000000838
INTRODUCTION: Evidence-based recommendations for sexual practices regarding anoreceptive intercourse (ARI) do not exist in patients with inflammatory bowel diseases undergoing restorative proctocolectomy with ileal pouch anal anastomosis (IPAA). This study surveys providers on perspectives and attitudes related to sexual practices after IPAA. METHODS: We developed a 23-item survey and distributed …
Hsa_circ_0004662 Accelerates the Progression of Ulcerative Colitis via the microRNA-532/HMGB3 Signalling Axis
Publication Year: 2025 Source: J Cell Mol Med PMID: 40099942 DOI: 10.1111/jcmm.70430
Increasing research has indicated that circular RNAs (circRNAs) are crucial for the development of ulcerative colitis (UC). Thus, we attempted to identify the role of hsa_circ_0004662 in UC progression. Hsa_circ_0004662 expression was determined via qRT-PCR. Lipopolysaccharide (LPS)-induced inflammation in normal colonic epithelial cells (ECs). The hsa_circ_0004662 content was then assessed …
Stromal Cell Subsets Show Model-Dependent Changes in Experimental Colitis and Affect Epithelial Tissue Repair and Immune Cell Activation
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40100003 DOI: 10.1093/ibd/izae255
BACKGROUND: Previous work on inflammatory bowel disease (IBD) revealed changes in the abundance of colonic stromal subsets during intestinal inflammation. However, it is currently unknown whether these stromal cell subset changes are also reflected in different IBD mouse models and how commonly used IBD therapies affect stromal cell subset composition. …
Systematic review on the use of artificial intelligence to identify anatomical structures during laparoscopic cholecystectomy: a tool towards the future
Publication Year: 2025 Source: Langenbecks Arch Surg PMID: 40100424
PURPOSE: Bile duct injury (BDI) during laparoscopic cholecystectomy (LC) is a dreaded complication. Artificial intelligence (AI) has recently been introduced in surgery. This systematic review aims to investigate whether AI can guide surgeons in identifying anatomical structures to facilitate safer dissection during LC. METHODS: Following PROSPERO registration CRD-42023478754, a Preferred …
Calming an Inflamed Gut: New drugs, and diets, soothe painful inflammatory bowel disease
Publication Year: 2025 Source: Sci Am PMID: 40100728
No Abstract
Development and validation of a risk prediction tool for the diagnosis of inflammatory bowel disease in patients presenting in primary care with abdominal symptoms
Publication Year: 2025 Source: J Crohns Colitis PMID: 40100743 DOI: 10.1093/ecco-jcc/jjaf044
INTRODUCTION: Patients with inflammatory bowel disease (IBD) may experience delays in their diagnosis. This study aimed to develop and validate a risk prediction tool for IBD. METHODS: A retrospective cohort study was conducted using primary care data from 2010 to 2019, including symptomatic patients aged >/=18. UK-based primary care databases …
Brusatol ameliorates intestinal mucosal injury in ulcerative colitis via activating IL-22/STAT3 pathway
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40101416
Brusatol (BR) is an active compounds isolated from Brucea javanica, a Chinese herbal medicine that is famous for its anti-diarrheal effect. We have previously reported that BR mitigated inflammation in murine ulcerative colitis (UC) models. However, BR's role in intestinal mucosal healing, which is recently established as central strategy for …
Phellodendrine ameliorates intestinal inflammation and protects mucosal barrier via modulating COL1A1, VCAM1 and IL-17 a
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40101527 DOI: 10.1016/j.intimp.2025.114403
BACKGROUND: Phellodendrine (PHE) has anti-inflammatory and antioxidant effects. However, the function of PHE in treating inflammatory bowel disease (IBD) has not been fully elucidated. The aim of this study was to investigate the effects and mechanisms of PHE on IBD with in vivo and in vitro assays. MATERIALS AND METHODS: …
A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation
Publication Year: 2025 Source: Neuron PMID: 40101721
Enteric infections often cause long-term sequelae, including persistent gastrointestinal symptoms, such as pain, discomfort, or irritable bowel syndrome. The plethora of sensory symptoms indicates that gut-innervating neurons might be directly affected by inflammation. However, sequencing studies of neurons in the gastrointestinal tract are hampered by difficulties in purifying neurons, especially …
Application of Internet Hospitals in the Disease Management of Patients With Ulcerative Colitis: Retrospective Study
Publication Year: 2025 Source: J Med Internet Res PMID: 40101745
BACKGROUND: Ulcerative colitis (UC) is a chronic disease characterized by frequent relapses, requiring long-term management and consuming substantial medical and social resources. Effective management of UC remains challenging due to the need for sustainable remission strategies, continuity of care, and access to medical services. Intelligent diagnosis refers to the use …
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