Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Identification of Bioactive Compounds and Potential Mechanisms of Fuzi in the Treatment of Ulcerative Colitis by Integrating Network Pharmacology and Experimental Validation
Publication Year: 2025 Source: Biol Pharm Bull PMID: 40101980
Ulcerative colitis (UC) is a chronic inflammatory bowel disease without efficient treatment. Fuzi has anti-inflammatory and immunomodulatory properties. However, the bioactive compounds and mechanisms of fuzi in the treatment of UC are not completely understood. The active components of fuzi were retrieved from Traditional Chinese Medicine Database System Pharmacology and …
Unique clinical, morphological, and molecular characteristics of tumors associated with PSC-IBD
Publication Year: 2025 Source: Virchows Arch PMID: 40102272 DOI: 10.1007/s00428-025-04072-y
Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease characterized by chronic inflammation and progressive fibrosis of the biliary tree, leading to significant liver function impairment over time. There is a strong association with inflammatory bowel diseases (IBD), together representing a distinct and complex medical condition. Patients with PSC-IBD …
Fibrosis: cross-organ biology and pathways to development of innovative drugs
Publication Year: 2025 Source: Nat Rev Drug Discov PMID: 40102636
Fibrosis is a pathophysiological mechanism involved in chronic and progressive diseases that results in excessive tissue scarring. Diseases associated with fibrosis include metabolic dysfunction-associated steatohepatitis (MASH), inflammatory bowel diseases (IBDs), chronic kidney disease (CKD), idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc), which are collectively responsible for substantial morbidity and …
Metabolic musculoskeletal disorders in patients with inflammatory bowel disease
Publication Year: 2025 Source: Korean J Intern Med PMID: 40102707 DOI: 10.3904/kjim.2024.359
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder that affects not only the gastrointestinal tract but also extraintestinal organs, leading to various extraintestinal manifestations and complications. Among these, musculoskeletal disorders such as osteoporosis, sarcopenia, and axial and peripheral spondyloarthritis are the most …
Tofacitinib for ulcerative colitis in Brazil: a multicenter observational study on effectiveness and safety
Publication Year: 2025 Source: BMC Gastroenterol PMID: 40102788
AIM: To assess the real-life, long-term effectiveness and safety of tofacitinib in a large cohort of patients with refractory or difficult-to-treat ulcerative colitis (UC). METHODS: This multicenter, retrospective, observational cohort study included patients with moderately to severely active UC who received tofacitinib for at least 8 weeks. Clinical remission and …
Reunderstanding the classical prescription Banxia Xiexin Decoction: new perspectives from a comprehensive review of clinical research and pharmacological studies
Publication Year: 2025 Source: Chin Med PMID: 40102869
Classical prescriptions of Chinese medicine represent the crystallized wisdom of millennia of clinical practice, enduring as cornerstones of therapeutic intervention due to their demonstrated efficacy across generations. Their evolving role in modern healthcare systems reflects shifting disease patterns, scientific advancements, and global health priorities. Banxia Xiexin Decoction (BXD), formulated by …
Development of the natural history component of an early economic model for primary sclerosing cholangitis
Publication Year: 2025 Source: Orphanet J Rare Dis PMID: 40102907
BACKGROUND: Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic disease that can progress to cirrhosis and liver failure. The natural history of PSC is variable as liver enzymes and liver symptoms fluctuate over time. Several drugs for PSC are under investigation, but there are currently no economic models to …
[Electroacupuncture improves colonic mucosal barrier damage by regulating NLRP3/Caspase-1/GSDMD signaling pathway and inhibiting pyroptosis in ulcerative colitis mice]
Publication Year: 2025 Source: Zhen Ci Yan Jiu PMID: 40103379
OBJECTIVES: To observe the effect of electroacupuncture (EA) at "Tianshu" (ST25) and "Zusanli" (ST36) on NOD-like receptor protein 3(NLRP3)/cysteine aspartate specific protease 1 (Caspase-1)/gasdermin D (GSDMD) pyroptosis signaling pathway in ulcerative colitis (UC) mice, so as to explore its mechanism in improving UC by protecting intestinal barrier. METHODS: Fifty male …
PPARγ/β/δ Agonists Can Ameliorate Dextran Sodium Sulfate-Induced Colitis and Modulate Gut Microbiota
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 40103411 DOI: 10.1111/jgh.16929
BACKGROUND AND AIM: Peroxisome proliferator-activated receptors (PPARs), as nuclear receptors, modulate both lipid metabolism and inflammatory/immune processes. This study examines the impact of modulating the activities of the PPAR subtypes PPARbeta/eth and PPARgamma on the gut microbiota in inflammatory bowel disease (IBD). METHODS: Mice with dextran sulfate sodium (DSS)-induced acute …
Self-Nourishing and Armored Probiotics via Egg-Inspired Encapsulation
Publication Year: 2025 Source: Adv Healthc Mater PMID: 40103525
The gut microbiota plays an essential role in regulating overall physiology, including metabolism and neurological and immune functions. Therefore, their dysregulation is closely associated with metabolic disorders, such as obesity and diabetes, as well as other pathological conditions, including inflammatory bowel diseases, cancer, and neurological disorders. Probiotics are commonly used …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide