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Advances in intestinal epithelium and gut microbiota interaction
Publication Year: 2025 Source: Front Microbiol PMID: 40104591
The intestinal epithelium represents a critical interface between the host and external environment, serving as the second largest surface area in the human body after the lungs. This dynamic barrier is sustained by specialized epithelial cell types and their complex interactions with the gut microbiota. This review comprehensively examines the …
Inflammatory bowel disease-associated serrated lesions with dysplasia are frequently associated with advanced neoplasia: supporting a unified classification approach
Publication Year: 2025 Source: Histopathology PMID: 40104985 DOI: 10.1111/his.15448
AIMS: Inflammatory bowel disease (IBD)-associated serrated lesions are categorized into three distinct subtypes: traditional serrated adenoma (TSA)-like lesion, sessile serrated lesion (SSL)-like lesion, and serrated lesion, not otherwise specified (NOS). Although the risk of neoplastic progression of serrated lesions without dysplasia has not been shown to exceed that of sporadic …
Serum extracellular RNAs as a noninvasive approach to differentiate inflammatory bowel disease subtypes: a proof-of-concept study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40105742 DOI: 10.1093/ecco-jcc/jjaf047
BACKGROUND AND AIMS: Extracellular RNAs (exRNAs), including in serum, show potential as noninvasive biomarkers. However, their (patho)physiological role is still not fully understood. In this study, we characterized serum exRNAs in patients with inflammatory bowel diseases (IBDs) and evaluated their ability to differentiate ulcerative colitis (UC) from Crohn's disease (CD). …
Logistic regression and covariate-balanced matching analysis of lichen planus and inflammatory gastrointestinal disorders
Publication Year: 2025 Source: Arch Dermatol Res PMID: 40106053
No Abstract
Persistence and Efficacy of Ustekinumab in Crohn's Disease After Anti-TNF Failure: An Observational Study
Publication Year: 2025 Source: Dig Dis Sci PMID: 40106111 DOI: 10.1007/s10620-025-08978-0
BACKGROUND: Anti-TNF treatment failure in Crohn's disease is common, and the literature on the selection of subsequent treatment is scant. Ustekinumab may be associated with high persistence rates and it appears to be effective in perianal disease. AIMS: Primary objective: persistence, clinical, and biologic remission with ustekinumab. SECONDARY OBJECTIVES: Persistence …
Vibrational exercise for Crohn's to observe response (VECTOR): Protocol for a randomized controlled trial
Publication Year: 2025 Source: PLoS One PMID: 40106525
Crohn's disease (CD) is a long-term inflammatory gastrointestinal disorder, often adversely affecting physical, emotional, and psychological well-being. Pharmaceutical management is habitually adopted; although medicinal therapies require continuous administration, and are often associated with significant side effects and low adherence rates. Whole body vibration (WBV) represents a non-invasive technique, that provides …
Microfluidic-derived montmorillonite composite microparticles for oral codelivery of probiotic biofilm and postbiotics
Publication Year: 2025 Source: Sci Adv PMID: 40106563
Oral delivery of probiotics has shown promising effects in modulating the gut microbiota and treating ulcerative colitis (UC). However, the therapeutic efficacy is restricted by gastrointestinal assaults, poor mucosal adhesion, and single therapeutic modality. Here, we developed acid-resistant, gut-environment-responsive composite microparticles based on microfluidic electrospray for the oral codelivery of …
Multifunctional Double-Loaded Oral Nanoplatform for Computed Tomography Imaging-Guided and Integrated Treatment of Inflammatory Bowel Disease
Publication Year: 2025 Source: ACS Nano PMID: 40106686 DOI: 10.1021/acsnano.4c18865
Excessive reactive oxygen species, disruption of the epithelial barrier, immune dysregulation, and gut microbiota imbalance are key factors driving the onset of inflammatory bowel disease (IBD) and complicating its treatment. Prompt diagnosis of diseases and precise delivery of therapeutic agents to inflamed intestinal sites offer promising targeted strategies for effectively …
Monthly Variations in Colorectal Cancer Screening Tests Among Federally Qualified Health Center Patients in Missouri: Quality Improvement Project
Publication Year: 2025 Source: JMIR Cancer PMID: 40106833
BACKGROUND: Cancer is the second leading cause of death in the United States. Compelling evidence shows screening detects colorectal cancer (CRC) at earlier stages and prevents the development of CRC through the removal of precancerous polyps. The Healthy People 2030 goal for CRC screening is 68.3%, but only 36.5% of …
Thiosulphate sulfurtransferase: Biological roles and therapeutic potential
Publication Year: 2025 Source: Redox Biol PMID: 40107018
Mitochondria are central to eukaryotic cell function, driving energy production, intermediary metabolism, and cellular homeostasis. Dysregulation of mitochondrial function often results in oxidative stress, a hallmark of numerous diseases, underscoring the critical need for maintaining mitochondrial integrity. Among mitochondrial enzymes, thiosulfate sulfurtransferase (TST) has emerged as a key regulator of …
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