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Modifiable risk factors associated with the risk of developing Parkinson's disease: a critical review
Publication Year: 2025 Source: Arq Neuropsiquiatr PMID: 40107260
The etiology of Parkinson's disease (PD) is complex and multifactorial, depending on interactions involving environmental/lifestyle and genetic factors. The genetic aspects of the disease are becoming well characterized, while the environmental factors still need further investigation. In the present narrative review, we have described the most concrete evidence of associations …
Estrogen receptor β alleviates colitis in intestinal epithelial cells and activates HIF-1a and ATG-9a-mediated autophagy
Publication Year: 2025 Source: Exp Cell Res PMID: 40107441 DOI: 10.1016/j.yexcr.2025.114520
Estrogen receptor beta (ERbeta) plays a pivotal role in regulating intestinal epithelial function and inflammation. Its involvement in inflammatory bowel diseases (IBD), particularly in ulcerative colitis (UC), remains poorly understood, despite emerging evidence pointing to its anti-inflammatory properties. This study investigated ERbeta expression in UC patients using quantitative PCR, Western …
Capsule Endoscopy-Guided Proactive Treat-to-Target Versus Continued Standard Care in Patients With Quiescent Crohn's Disease: A Randomized Controlled Trial
Publication Year: 2025 Source: Gastroenterology PMID: 40107519
BACKGROUND & AIMS: Optimal treat-to-target strategies for Crohn's disease (CD) are still being sought. The value of video capsule endoscopy (VCE) to guide proactive treat-to-target optimization in CD was examined. METHODS: A randomized controlled trial of patients with small bowel-involved (L1/L3) CD in corticosteroid-free clinical remission (Crohn's Disease Activity Index …
Profiles of Disease Burden in Patients With Inflammatory Bowel Disease and the Impact on Psychosocial Adaptation
Publication Year: 2025 Source: Nurs Health Sci PMID: 40107667 DOI: 10.1111/nhs.70083
The chronic recurrence and systemic reaction of inflammatory bowel disease (IBD) have adverse effects on physical and psychological health of patients, while the patterns of disease burden degree vary among patients with IBD. The perceived disease burden probably affects patients' psychosocial adaptation. This study aimed to use latent profile analysis …
Older Adults with Inflammatory Bowel Disease Epidemiology in the United States: 2000-2021
Publication Year: 2025 Source: Dig Dis Sci PMID: 40108101 DOI: 10.1007/s10620-025-08976-2
BACKGROUND: As the United States population ages, the incidence and prevalence of inflammatory bowel disease (IBD) among older adults are on the rise. AIMS: This study provides updated estimates of the IBD burden in older adults and examines changes from 2000 to 2021. METHODS: We analyzed data on IBD incidence, …
Comparative analysis of Parkinson's and inflammatory bowel disease gut microbiomes reveals shared butyrate-producing bacteria depletion
Publication Year: 2025 Source: NPJ Parkinsons Dis PMID: 40108151 DOI: 10.1038/s41531-025-00894-4
Epidemiological studies reveal that inflammatory bowel disease (IBD) is associated with an increased risk of Parkinson's disease (PD). Gut dysbiosis has been documented in both PD and IBD, however it is currently unknown whether gut dysbiosis underlies the epidemiological association between both diseases. To identify shared and distinct features of …
Comorbidities in Canadian patients with hereditary angioedema: a quantitative survey study
Publication Year: 2025 Source: Allergy Asthma Clin Immunol PMID: 40108700
BACKGROUND: Evidence linking hereditary angioedema (HAE) to the potential association of developing other comorbidities, and how it is affected by HAE treatment is needed. The objective of this study is to identify comorbidities and measure the prevalence in HAE patients, compared to the prevalence in the general population using multiple …
Enhancing diagnostics: ChatGPT-4 performance in ulcerative colitis endoscopic assessment
Publication Year: 2025 Source: Endosc Int Open PMID: 40109324 DOI: 10.1055/a-2542-0943
BACKGROUND AND STUDY AIMS: The Mayo Endoscopic Subscore (MES) is widely utilized for assessing mucosal activity in ulcerative colitis (UC). Artificial intelligence has emerged as a promising tool for enhancing diagnostic precision and addressing interobserver variability. This study evaluated the diagnostic accuracy of ChatGPT-4, a multimodal large language model, in …
The role of intestinal macrophage polarization in colitis-associated colon cancer
Publication Year: 2025 Source: Front Immunol PMID: 40109347
Chronic inflammation of the intestine is a significant risk factor in the development of colorectal cancer. The emergence of colitis and colorectal cancer is a complex, multifactorial process involving chronic inflammation, immune regulation, and tumor microenvironment remodeling. Macrophages represent one of the most prevalent cells in the colorectal cancer microenvironment …
Summary Concerning 16 Years of Research Activities in the Department of Pediatrics at Juntendo University
Publication Year: 2025 Source: Juntendo Med J PMID: 40109399 DOI: 10.14789/ejmj.JMJ24-0029-P
I described mainly about my research activities in the 16 years and 8 months since I became professor of pediatrics at Juntendo University. Since the fulfillment of research activities has a great influence on clinical activities, and sufficient research cannot be conducted without enhanced educational activities, I have tried to …
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