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Association of early therapeutic drug monitoring of adalimumab with biologic remission and drug survival in Crohn's Disease
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40110342
BACKGROUND: Therapeutic drug monitoring of adalimumab (ADA) is still controversial. OBJECTIVES: To study the association between ADA trough levels in the early stages of treatment with biological remission (BR) and drug survival in Crohn's disease (CD). DESIGN: Retrospective cohort study. METHODS: Patients treated with ADA with available trough levels at …
Quality of life and burden of disease in a Mexican population with inflammatory bowel disease: an analysis of the RISE-MX trial
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40110343 DOI: 10.1177/17562848251318032
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) that have a negative impact on patient quality of life (QOL). OBJECTIVE: To evaluate QOL, work productivity, use of healthcare resources, and medical costs in patients with IBD from the RISE-MX trial. DESIGN: RISE-MX was a …
Roles of fibroblasts in the pathogenesis of inflammatory bowel diseases and IBD-associated fibrosis
Publication Year: 2025 Source: Int Immunol PMID: 40110813 DOI: 10.1093/intimm/dxaf015
Ulcerative colitis and Crohn's disease, the principal forms of inflammatory bowel disease (IBD), are chronic relapsing inflammatory disorders of the gastrointestinal tract. The incidence and prevalence of IBD have been increasing worldwide, but their etiology remains largely unknown. Although anti-TNF agents can be highly effective in IBD patients, 10%-40% of …
Mucin 5AC as a Biomarker for Sessile Serrated Lesions: Results From a Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Clin Transl Gastroenterol PMID: 40110854
INTRODUCTION: Sessile serrated lesions (SSLs) are a class of colon polyps challenging to detect through current screening methods but highly associated with colon cancer. To improve detection, we sought a biomarker sensitive for SSLs. Recent endoscopic and histopathologic studies suggest that SSLs are associated with alterations in intestinal mucin expression, …
Misinterpretation and misapplication of biomarkers in inflammatory bowel disease: how do we avoid this?
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 40110976 DOI: 10.1080/17474124.2025.2482980
INTRODUCTION: The management of inflammatory bowel disease (IBD) has evolved substantially over the past decade, with the emergence of new advanced therapies presenting unprecedented challenges in clinical decision-making. While these therapies provide patients with more opportunities to get better, biomarkers to guide their use remain elusive. AREAS COVERED: This article …
The Impact of Diet and Nutrition on the Oral Microbiome
Publication Year: 2025 Source: Adv Exp Med Biol PMID: 40111685
At present, it is well known that oral health is essential for the well-being of the body as a whole, thanks to the increasing awareness of how various oral diseases, including periodontal disease, oral carcinomas, and other conditions, have a close connection with various systemic disorders. In recent decades, studies …
Discovery of Novel Sulfonylurea NLRP3 Inflammasome Inhibitor for the Treatment of Multiple Inflammatory Diseases
Publication Year: 2025 Source: J Med Chem PMID: 40112040 DOI: 10.1021/acs.jmedchem.4c02813
NLRP3 inflammasome is critical in innate immunity and inflammatory responses. A series of novel sulfonylurea-based NLRP3 inflammasome inhibitors was designed and synthesized. Notably, compound 15 exhibited the potent NLRP3 inhibitory activity, effectively suppressing IL-1beta secretion in THP-1 (IC(50) = 23 nM), demonstrating better efficacy compared to MCC950. It selectively inhibits …
Modified Shi Hui San decoction ameliorates murine experimental colitis through multiple mechanisms
Publication Year: 2025 Source: Fitoterapia PMID: 40112896
BACKGROUND: Modified Shi Hui San (MSHS) has shown excellent therapeutic effects on ulcerative colitis (UC) patients clinically in China. However, the exact mechanism underlying its effect remains unclear and needs to further investigation. AIMS: This study aimed to investigate the therapeutic effects of modified Shi Hui San decoction (MSHSD) in …
FUT2-dependent fucosylation of LAMP1 promotes the apoptosis of colorectal cancer cells by regulating the autophagy-lysosomal pathway
Publication Year: 2025 Source: Cancer Lett PMID: 40112906 DOI: 10.1016/j.canlet.2025.217643
Fucosyltransferase 2 (FUT2) is an enzyme that adds fucose to proteins or lipids via alpha-1,2-fucosylation in the intestinal mucosa. While FUT2 deficiency is linked to increased susceptibility to inflammatory bowel disease (IBD), its role in colorectal cancer (CRC) is unclear, and the molecular mechanisms involved remain largely unknown. We established …
Steroid constituents of Solidago canadensis alleviate LPS-induced inflammation via AMPK regulated mitophagy/NLRP3 and NF-κB pathway
Publication Year: 2025 Source: Eur J Pharmacol PMID: 40113066 DOI: 10.1016/j.ejphar.2025.177512
Inflammation is a major risk factor for a variety of human diseases, such as sepsis, Inflammatory Bowel Disease (IBD) and also major cardiovascular disease including atherosclerosis. Solidago canadensis is used as a traditional medicine to treat inflammation-related diseases. However, the component with anti-inflammatory activity of Solidago canadensis is not clear. …
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