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Protective effects of human breast milk-derived exosomes on inflammatory bowel disease through modulation of immune cells
Publication Year: 2025 Source: NPJ Sci Food PMID: 40113828
Human breast milk (HBM)-derived exosomes play a crucial role not only in infant nutrition but also in modulating inflammation, immunity, and epithelial cell protection. This study investigated how HBM-derived exosomes regulate immune cell development and function. The exosomes promoted the differentiation of naive CD4(+) T cells into Treg and Th2 …
Treatment of IL-10RA deficiency of pediatric patients with very early onset inflammatory bowel disease by allogeneic haematopoietic stem cell transplantation
Publication Year: 2025 Source: Sci Rep PMID: 40113867 DOI: 10.1038/s41598-025-92979-6
Very early onset inflammatory bowel disease (VEO-IBD) with interleukin-10 receptor-A (IL-10RA) defects is characterised by severe and unmanageable intestinal inflammation, perianal lesions, and a high mortality rate, with the onset of the disease occurring at a very early age. Currently, allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the …
Meta-Analysis: Pregnancies With Inflammatory Bowel Disease Complicated by Intrahepatic Cholestasis of Pregnancy
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40114011 DOI: 10.1111/apt.70096
BACKGROUND: Inflammatory Bowel Disease (IBD) requires maintenance of remission during pregnancy to avoid poor maternal and fetal outcomes. Intrahepatic cholestasis of pregnancy (ICP) could also increase these risks. AIMS: To examine the prevalence of ICP in pregnancies with IBD and associations with thiopurine exposure. METHODS: An electronic search of MEDLINE, …
Increase of VEGF and Fibronectin expression and ultrastructural alterations of intercellular junctions in a swab negative patient after SARS-COV-2 infection
Publication Year: 2025 Source: Virol J PMID: 40114185
BACKGROUND: SARS-CoV-2 infection has been responsible of COrona VIrus Disease (COVID-19) pandemia and can cause a variety of symptoms including gastrointestinal disorders, abdominal pain and liver injury. The host receptor for SARS-CoV-2, ACE2, is expressed in gut and SARS-CoV-2 infection could induce vascular damage and immune system dysregulation, creating an …
Reducing severity of inflammatory bowel disease through colonization of Lactiplantibacillus plantarum and its extracellular vesicles release
Publication Year: 2025 Source: J Nanobiotechnology PMID: 40114208 DOI: 10.1186/s12951-025-03280-7
Inflammatory bowel disease (IBD) is characterized by compromised intestinal barrier function and a lack of effective treatments. Probiotics have shown promise in managing IBD due to their ability to modulate the gut microbiota, enhance intestinal barrier function, and exert anti-inflammatory effects. However, the specific mechanisms through which probiotics exert these …
Antireflux mucosectomy for refractory gastroesophageal reflux disease following peroral endoscopic myotomy
Publication Year: 2025 Source: Clin Endosc PMID: 40114461
No Abstract
Anti-interleukin-23 treatment linked to improved Clostridioides difficile infection survival
Publication Year: 2025 Source: Gut Microbes PMID: 40114558
Clostridioides difficile is a leading cause of healthcare-associated infection, and an unacceptably high proportion of patients with C. difficile infection die despite conventional antibiotic treatment. Host-directed immunotherapy has been proposed as an ideal treatment modality for C. difficile infection to mitigate the underlying toxin-mediated pathogenic immune response while sparing protective …
Sugar-Sweetened Beverages, Artificially Sweetened Beverages and Sugar Forms With Long-Term Risk of Irritable Bowel Syndrome: A Large-Scale Prospective Cohort Study
Publication Year: 2025 Source: Food Sci Nutr PMID: 40115249
We aimed to examine the prospective association of sugar-sweetened beverages (SSB), artificially sweetened beverages (ASB), natural juice, and sugar forms with irritable bowel syndrome (IBS). Participants free of IBS, celiac disease, inflammatory bowel disease, and any cancer at recruitment were included (N = 178,711, 53.1% female). SSB, ASB, natural juice, …
Bibliometric analysis of Crohn's disease in children, 2014-2024
Publication Year: 2025 Source: Front Pediatr PMID: 40115319
BACKGROUND: In recent years, the incidence of Crohn's disease has risen significantly in the pediatric population, and its prolongation has had a major impact on children's physical and mental health as well as on the quality of life of their families, and has therefore received extensive attention from scholars around …
Mitophagy and immune cell interaction: insights into pathogenesis and potential targets for necrotizing enterocolitis
Publication Year: 2025 Source: Transl Pediatr PMID: 40115463
BACKGROUND: Neonatal necrotizing enterocolitis (NEC) is a fatal disease in early life characterized by an inflammatory response or even necrosis of the bowel wall. NEC is one of the leading causes of preterm infant mortality. The pathogenesis of NEC is intricate and involves mitochondrial damage to intestinal cells and infiltration …
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