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Advances in gut microbiota functions in inflammatory bowel disease: Dysbiosis, management, cytotoxicity assessment, and therapeutic perspectives
Publication Year: 2025 Source: Comput Struct Biotechnol J PMID: 40115534 DOI: 10.1016/j.csbj.2025.02.026
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, have become increasingly prevalent across all human generations. Despite advances in diagnosis, effective long-term therapeutic options remain limited, with many patients experiencing recurrent symptoms after treatment. The multifactorial origins of ulcerative colitis are widely recognized, but the intestinal microbiome, particularly …
Management of Patients With Refractory Ulcerative Proctitis
Publication Year: 2025 Source: Gastroenterol Hepatol (N Y) PMID: 40115607
No Abstract
Use of Interleukin-23 Inhibitors for the Treatment of Inflammatory Bowel Disease
Publication Year: 2025 Source: Gastroenterol Hepatol (N Y) PMID: 40115655
No Abstract
Genetic factors that predict response and failure of biologic therapy in inflammatory bowel disease
Publication Year: 2025 Source: World J Exp Med PMID: 40115750 DOI: 10.5493/wjem.v15.i1.97404
Inflammatory bowel disease (IBD) represents a significant disease burden marked by chronic inflammation and complications that adversely affect patients' quality of life. Effective diagnostic strategies involve clinical assessments, endoscopic evaluations, imaging studies, and biomarker testing, where early diagnosis is essential for effective management and prevention of long-term complications, highlighting the …
Comprehensive analysis of anoikis-related gene signature in ulcerative colitis using machine learning algorithms
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40115777
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with an idiopathic origin, characterized by persistent mucosal inflammation. Anoikis is a programmed cell death mechanism activated during carcinogenesis to eliminate undetected isolated cells from the extracellular matrix. Although existing evidence indicates that anoikis contributes to the modulation of immune response, …
"Budding"-an early MRI feature established in a case-control study of perianal fistula mucinous adenocarcinoma
Publication Year: 2025 Source: J Gastrointest Oncol PMID: 40115924
BACKGROUND: Perianal fistula mucinous adenocarcinoma (FMA) usually presents at an advanced stage, necessitating extensive surgical resection. Symptoms of perianal pain and discharge are indistinguishable from fistula sepsis. Absence of defined features on magnetic resonance imaging (MRI) precludes early diagnosis. This study aims to validate MRI features that should increase suspicion …
Metal-Organic Frameworks for the Therapy of Inflammatory Diseases
Publication Year: 2025 Source: Adv Healthc Mater PMID: 40116524 DOI: 10.1002/adhm.202404334
Inflammation is a natural immune response triggered by harmful external or internal stimuli. However, when inflammation fails to resolve and restore basal homeostasis, it can lead to various inflammatory diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and diabetic chronic wound (DCW). The modulation of inflammation follows a …
Transcutaneous Auricular Vagus Nerve Stimulation: Efficacy, Applications, and Challenges in Mood Disorders and Autonomic Regulation-A Narrative Review
Publication Year: 2025 Source: Mil Med PMID: 40116526
BACKGROUND: Transcutaneous auricular Vagus Nerve Stimulation (taVNS) is a noninvasive technique that activates vagal projections in the brain and brainstem by stimulating the auricular branch of the vagus nerve. taVNS may be a safer alternative to invasive vagal nerve stimulation for treating treatment-resistant mood disorders, chronic pain, inflammation, cardiovascular dysfunction, …
"Shield" Armed Programmable Probiotics Harboring α-Aminoadipate Aminotransferase Gene Regulate Tryptophan Metabolism and Gut Microbiota to Alleviate the Inflammatory Bowel Disease
Publication Year: 2025 Source: J Agric Food Chem PMID: 40116595 DOI: 10.1021/acs.jafc.4c13017
Current treatment of inflammatory bowel disease (IBD) relies on anti-inflammatory and immunosuppressive agents. However, this concept is considered outdated due to its restricted efficacy and unavoidable side effects. Herein, a polynorepinephrine-coated programmable probiotic expressing alpha-aminoadipate aminotransferase (NE-EcN-pA) was constructed to improve the levels of kynurenic acid and xanthurenic acid in …
Bifidobacterium lactis ameliorates AOM/DSS-induced inflammation, dysbiosis, and colonic precancerous lesions
Publication Year: 2025 Source: Appl Microbiol Biotechnol PMID: 40116950
Bowel cancer is the third most common malignancy of tumors and one of the major causes of cancer-related death. Bowel precancerous conditions can develop without any symptoms, which either makes it difficult for early diagnosis or poses a poor prognosis/gloomy relapse. This study aimed to investigate the effects of Bifidobacterium …
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