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Healthy microbiome-moving towards functional interpretation
Publication Year: 2025 Source: Gigascience PMID: 40117176 DOI: 10.1093/gigascience/giaf015
BACKGROUND: Microbiome-based disease prediction has significant potential as an early, noninvasive marker of multiple health conditions linked to dysbiosis of the human gut microbiota, thanks in part to decreasing sequencing and analysis costs. Microbiome health indices and other computational tools currently proposed in the field often are based on a …
Dysregulation of γδ intraepithelial lymphocytes precedes Crohn's disease-like ileitis
Publication Year: 2025 Source: Sci Immunol PMID: 40117343
Intraepithelial lymphocytes expressing the gammadelta T cell receptor (gammadelta IELs) provide immunosurveillance of the intestinal barrier but are reduced in patients with active Crohn's disease (CD). Here, we report an underappreciated role for gammadelta IELs in maintaining immunological tolerance during the onset and progression of CD-like ileitis using TNF(DeltaARE/+) mice. …
Non-obstructive sinusoidal dilation in inflammatory bowel disease
Publication Year: 2025 Source: Clin Res Hepatol Gastroenterol PMID: 40118178
No Abstract
Modulation of intestinal signal transduction pathways: Implications on gut health and disease
Publication Year: 2025 Source: Eur J Pharmacol PMID: 40118324 DOI: 10.1016/j.ejphar.2025.177531
The gastrointestinal (GI) tract is essential for nutrient absorption and protection against pathogens and toxins. Its epithelial lining undergoes continuous renewal every 3-5 days, driven by intestinal stem cells (ISCs). ISCs are primarily of two types: actively proliferating crypt base columnar cells (CBCs), marked by Lgr5 expression, and quiescent label-retaining …
Ophiopogonis Radix fructan-selenium nanoparticles for dual amelioration of ulcerative colitis and anti-colon cancer
Publication Year: 2025 Source: Int J Biol Macromol PMID: 40118427
Fructans demonstrate significant potential in preclinical models for treating inflammatory bowel disease and colorectal cancer by modulating gut microbiota homeostasis. In this research, ORP-SeNPs were prepared through a redox method. Their roles as colon-targeted delivery carriers and stabilizers were examined for treating inflammatory bowel disease and colorectal cancer. ORP-SeNPs showed …
Cardiac arrhythmia in patients with inflammatory bowel disease: a retrospective, population-based cohort study in Manitoba, Canada
Publication Year: 2025 Source: BMJ Open PMID: 40118486 DOI: 10.1136/bmjopen-2024-097687
OBJECTIVE: We aimed to characterise the association between inflammatory bowel disease (IBD) and IBD medications and risk of cardiac arrhythmia. DESIGN, SETTING AND PARTICIPANTS: In a retrospective population-based study using the University of Manitoba IBD Epidemiology Database (Manitoba, Canada) from 1984 to 2018, we identified 10 992 IBD cases and …
Associations of 2923 plasma proteins with incident inflammatory bowel disease in a prospective cohort study and genetic analysis
Publication Year: 2025 Source: Nat Commun PMID: 40118817 DOI: 10.1038/s41467-025-57879-3
The prospective relationship between proteomics and inflammatory bowel disease (IBD) remains largely underexplored, presenting potential of therapeutic interventions. Using data from 48,800 IBD-free participants in the UK Biobank Pharma Proteomics Project (UKB-PPP), we assessed associations between 2923 plasma proteins and incident IBD risk using Cox analysis. Mendelian randomization (MR) meta-analysis, …
Multi-omics insight into the molecular networks of mental disorder related genetic pathways in the pathogenesis of inflammatory bowel disease
Publication Year: 2025 Source: Transl Psychiatry PMID: 40118833 DOI: 10.1038/s41398-025-03299-2
Mental disorders are associated with inflammatory bowel disease (IBD), but the genetic pathophysiology is not fully understood. We obtained data on mental disorder-related gene methylation, expression, protein levels, and summary statistics of IBD, and performed Summary data-based Mendelian randomization and colocalization analyses to explore the causal associations and shared causal …
Klotho antiaging protein: molecular mechanisms and therapeutic potential in diseases
Publication Year: 2025 Source: Mol Biomed PMID: 40119098
Klotho, initially introduced as an anti-aging protein, is expressed in the brain, pancreas, and most prominently in the kidney. The two forms of Klotho (membrane-bound and soluble form) have diverse pharmacological functions such as anti-inflammatory, anti-oxidative, anti-fibrotic, tumour-suppressive etc. The membrane-bound form plays a pivotal role in maintaining kidney homeostasis …
Microbiome-derived secondary bile acids promote repair of colonic mucosa after injury
Publication Year: 2025 Source: EMBO Mol Med PMID: 40119173 DOI: 10.1038/s44321-025-00218-2
No Abstract
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