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A Case of Uterine Adenosarcoma and Colonic Endometriosis Masquerading as Inflammatory Bowel Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 40119242
BACKGROUND: Endometriosis is a prevalent gynecological condition that primarily affects women of reproductive age. When the gastrointestinal system is involved, it can lead to bowel dysfunction and pose diagnostic challenges. AIMS: To present a rare case of gastrointestinal endometriosis with concurrent uterine adenosarcoma, highlighting the diagnostic complexities and therapeutic considerations. …
Editorial: Cumulative Impact of Clinical Disease Activity, Biochemical Activity and Psychological Health on the Natural History of Inflammatory Bowel Disease During 8 Years of Longitudinal Follow-Up. Authors' Reply
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40119562
No Abstract
Editorial: Cumulative Impact of Clinical Disease Activity, Biochemical Activity and Psychological Health on the Natural History of Inflammatory Bowel Disease During 8 Years of Longitudinal Follow-Up
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40119566
No Abstract
Clinical Trials for Perianal Crohn's Disease: A Call for a Revised Approach
Publication Year: 2025 Source: Gastroenterology PMID: 40120773
No Abstract
Perforin Generated by CD8(+) T Cells Exacerbates Inflammatory Bowel Disease-Induced Depression by Promoting CXCL9 Production in Intestinal Epithelial Cells
Publication Year: 2025 Source: Gastroenterology PMID: 40120774 DOI: 10.1053/j.gastro.2025.02.036
BACKGROUND & AIMS: Approximately 25.2% of patients with inflammatory bowel disease (IBD) suffer from psychological disorders, particularly depression. Recent studies have indicated a close relationship between intestinal immunity and brain disorders. METHODS: We performed transcriptome analysis and immunofluorescence staining of colonic samples from patients with IBD. The role of perforin …
Nationwide trends in colectomy rates for ulcerative colitis in Brazil: An analysis of the unified public healthcare system
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 40120855
INTRODUCTION: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with significant global prevalence. Despite advancements in medical management, including the widespread use of biologic agents and small molecules, approximately 15-20% of patients eventually require surgery. This study aimed to analyze colectomy and hospitalization rates for UC in Brazil from …
Accuracy of superb microvascular imaging (SMI) in predicting endoscopic Crohn's disease activity
Publication Year: 2025 Source: Dig Liver Dis PMID: 40121159
BACKGROUND: Treat-to-target therapy in inflammatory bowel disease requires longitudinal assessment of disease activity and intestinal ultrasound (IUS) is a promising non-invasive and cheap technology to provide objective read-outs. Vascularization of the bowel wall is one key parameter on IUS. While this is conventionally done with Color doppler imaging, it is …
Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseases
Publication Year: 2025 Source: J Crohns Colitis PMID: 40121186 DOI: 10.1093/ecco-jcc/jjaf048
BACKGROUND AND AIMS: Inflammatory Bowel Diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are known to involve shifts in the T-cell repertoires of affected individuals, including clonal expansion of abundant T-cell populations in CD mucosal tissue. There are also differential HLA risk and protective alleles between CD and …
Bacterial membrane vesicles restore gut anaerobiosis
Publication Year: 2025 Source: NPJ Biofilms Microbiomes PMID: 40121189 DOI: 10.1038/s41522-025-00676-z
Inflammation damages the epithelial cell barrier, allowing oxygen to leak into the lumen of the gut. Respiring E. coli and other Enterobacteriaceae produce proinflammatory lipopolysaccharide, exacerbating inflammatory bowel disease. Here we show that respiring membrane vesicles (MV) from E. coli ameliorate symptoms in a mouse model of gut inflammation. Membrane …
Bulk and single-cell RNA sequencing reveal the roles of neutrophils in pediatric Crohn's disease
Publication Year: 2025 Source: Pediatr Res PMID: 40121337
BACKGROUND: Pediatric Crohn's disease (CD) is a chronic inflammatory bowel disorder that poses significant health risks to children. Although the precise etiology of CD remains elusive, further exploration is needed to identify diagnostic biomarkers and therapeutic targets. METHODS: This study utilized single-cell and bulk RNA sequencing data derived from ileal …
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