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GPR35 prevents osmotic stress induced cell damage
Publication Year: 2025 Source: Commun Biol PMID: 40121360
GPR35 is an orphan G-protein coupled receptor that has been implicated in the development of cancer. GPR35 regulates the Na(+)/K(+)-ATPase's pump and signalling function. Here we show GPR35's critical role in ion flux that in turn controls cellular osmotic pressure and Na(+)-dependent transport in HepG2 and SW480 cells. GPR35 deficiency …
Oral antimicrobial prophylaxis was associated with preventing surgical site infection following 2-stage restorative proctocolectomy in patients with ulcerative colitis
Publication Year: 2025 Source: Tech Coloproctol PMID: 40121608
BACKGROUND: Surgical site infection (SSI) is a critical issue in colorectal surgery because it decreases postoperative patient quality of life. The rate of SSI in patients with ulcerative colitis (UC) receiving immunosuppressive therapy is particularly high, suggesting that the SSI rate may increase with the introduction of biologic agents. METHODS: …
Acute transverse myelitis following SARS-CoV-2 infection during treatment for ulcerative colitis with anti-TNFα therapy
Publication Year: 2025 Source: Clin Neurol Neurosurg PMID: 40121774
We report a case of acute transverse myelitis (ATM) following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a 59-year-old man. This patient had been treated for ulcerative colitis (UC) for 4.5 years with several medications, including a tumor necrosis factor (TNF)-alpha inhibitor. Because this patient developed ATM almost …
The active ingredients and mechanism of Zuoqing San in the treatment of sigmoid ulcerative colitis by retention enema
Publication Year: 2025 Source: J Complement Integr Med PMID: 39983068
OBJECTIVES: This investigation aimed to evaluate the efficacy, key active ingredients, and mechanisms of Zuoqing San (ZQS), a traditional Chinese medicine formula, in managing sigmoid ulcerative colitis (SUC). METHODS: A cohort of 126 participants was recruited and treated with ZQS at a daily dosage of 100 mL for 12 weeks. …
Digital light processing of photo-crosslinkable gelatin to create biomimetic 3D constructs serving small intestinal tissue regeneration
Publication Year: 2025 Source: Biomater Adv PMID: 39983500 DOI: 10.1016/j.bioadv.2025.214232
Regeneration of small intestinal mucosal tissue could offer a promising strategy for Crohn's disease patients suffering from chronic inflammatory damage. Here, we aimed to develop hydrogels that mirror the villi and crypts of the small intestine and exhibit a physiological stiffness of G' ~ 1.52 kPa. For this purpose, we …
Oral delivery of ultra-small zwitterionic nanoparticles to overcome mucus and epithelial barriers for macrophage modulation and colitis therapy
Publication Year: 2025 Source: Acta Biomater PMID: 39983856
Ulcerative colitis (UC) is a chronic inflammatory disease of the colon that poses significant therapeutic challenges due to the intestinal mucus and epithelial barriers. In this study, ultra-small zwitterionic nanoparticles (HC-CB NPs) is developed based on glutathione (GSH)-responsive hyperbranched polycarbonate to enhance the oral delivery of drugs and overcome these …
Isolation and effect of physical modification on the release characteristics Euryale ferox Salisb polysaccharide
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39984069
This study investigates the potential of native and physically modified Euryale ferox Salisb. (makhana) starch as excipients for colon-targeted drug delivery systems. Physical modifications, including pregelatinization, retrogradation, ultrasonication, autoclave heating, and osmotic pressure treatment, were applied to enhance delayed-release characteristics. Functional analysis revealed improvements in swelling, solubility, and water-holding capacity, …
β-1,3-glucans from Euglena Gracilis protects against ulcerative colitis via modulating the gut barrier, T-cell immunity and gut microbiota
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39984099
Ulcerative colitis (UC) is characterized by impaired gut barrier, dysregulated immune responses and pronounced gut dysbiosis. Euglena gracilis (EG), rich in beta-1,3-glucan (EGP), exhibits immunomodulatory properties, yet its effects on colitis and EGP's role as a core bioactive component are unclear. The aim of this study was to investigate the …
Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database
Publication Year: 2025 Source: Pharmacol Res Perspect PMID: 39984304
Interstitial lung disease (ILD) is a clinically relevant adverse event associated with biologic agent use. However, the current incidence of ILD remains unclear as large-scale risk assessments of biologic agents have not been conducted. The aim of this study was to clarify the association between biologic agent use and ILD …
PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal mucosal protection
Publication Year: 2025 Source: Nat Commun PMID: 39984444
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