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Unveiling the superior diagnostic efficacy of double-balloon endoscopy compared to small intestine dual-energy CT enterography in small bowel Crohn's disease
Publication Year: 2025 Source: BMC Gastroenterol PMID: 39984842
BACKGROUND: Dual-energy computed tomography enterography (DECTE) has significantly improved gastrointestinal imaging quality. Double-balloon endoscopy (DBE) has enabled comprehensive visualization of the small intestinal mucosa. This study aimed to assess the diagnostic efficacy of small-intestine DECTE and DBE for small bowel Crohn's disease (CD). METHODS: This retrospective study was conducted between …
Is the risk of heart failure increased in patients with inflammatory bowel disease? A meta-analysis
Publication Year: 2025 Source: J Investig Med PMID: 39985227
No Abstract
Chronic Stenosing Enteritis: A Variant of Chronic Non-specific Stenosing Ulceration (CNSU) that Is Distinct from Crohn's Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 39985738
OBJECTIVE: Chronic non-specific stenosing ulcers (CNSU) of the small intestine is an under-recognized syndrome characterized by iron-deficiency anemia, superficial ulcerations, and stenoses of the small intestine. Despite the recent identification of a gene mutation SLCO2A1 in some Japanese patients that plays an etiological role, much remains uncertain about the etiology …
Colon-Targeted Hydrogel Microsphere System Encapsulating Oleic Acid-Emodin for Crohn's Disease Treatment via Ferroptosis Inhibition
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 39985760
Crohn's disease (CD) is a relapsing, systemic inflammatory disease that primarily affects the gastrointestinal tract and is often accompanied by extraintestinal manifestations and associated immune disorders. However, current pharmacological treatments for CD encounter several challenges, such as a lack of precise drug targeting and inadequate retention of drugs in the …
Integrating early response biomarkers in pharmacokinetic models: A novel method to individualize the initial infliximab dose in patients with Crohn's disease
Publication Year: 2025 Source: Clin Transl Sci PMID: 39985779
The use of model-informed precision dosing to personalize infliximab has been shown to improve both the acquisition of concentration targets and clinical outcomes during maintenance. Current iterations of infliximab pharmacokinetic models include time-varying covariates of drug clearance, however, not accounting for the expected improvements in the covariates can lead to …
Machine learning-based characterization of PANoptosis-related biomarkers and immune infiltration in ulcerative colitis: A comprehensive bioinformatics analysis and experimental validation
Publication Year: 2025 Source: Int Immunopharmacol PMID: 39986196
Ulcerative colitis (UC) is a heterogeneous autoimmune condition. PANoptosis, a new form of programmed cell death, plays a role in inflammatory diseases. This study aimed to identify differentially expressed PANoptosis-related genes (PRGs) involved in immune dysregulation in UC. Three key PRGs-BIRC3, MAGED1, and PSME2 were found using weighted gene co-expression …
Anti-inflammatory effects of Rhus javanica ethanol extract for pulmonary and colonic disorders
Publication Year: 2025 Source: Phytomedicine PMID: 39986220
BACKGROUND: Rhus javanica is a traditional medicinal herb widespread in East Asia, including Korea, China, and Japan. Valued for its antidiarrheal, bactericidal, and anti-inflammatory properties, it epitomizes the synergy of traditional wisdom and natural benefits. PURPOSE: This study aimed to investigate the anti-inflammatory properties of Rhus javanica ethanol extract (Rj-EE) …
Anti-inflammatory withanolides from Physalis minima and their therapeutic potential against ulcerative colitis in mice
Publication Year: 2025 Source: Phytochemistry PMID: 39986410
Eleven undescribed withanolides, phyminimolides I-XI (1-11), along with eight known derivatives (12-19), were isolated from the whole plant of Physalis minima Linn. Their structures were elucidated by extensive spectroscopic methods, including 1D-NMR, 2D-NMR, HRESIMS, IR, experimental electronic circular dichroism, quantum chemical calculation, and X-ray crystallography. The anti-inflammatory potential of these …
Insoluble dietary fibers from Hancornia speciosa alleviates chronic constipation on experimental loperamide-induced model
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39986516
Constipation is one of the most prevalent intestinal disorders and is characterized by the presence of hard and dry stools, excessive effort, infrequent bowel movements, abdominal distension and pain, and others. Low fiber consumption may be one of the nutritional factors that greatly influence the development of constipation. Previous studies …
Effects of senotherapeutics on gut microbiome dysbiosis and intestinal inflammation in Crohn's disease: A pilot study
Publication Year: 2025 Source: Transl Res PMID: 39986536 DOI: 10.1016/j.trsl.2025.02.004
Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, and is usually accompanied by dysbiosis in the gut microbiome, a factor that contributes to disease progression. Excessive production of reactive oxygen species (ROS) because of gut microbiome dysbiosis-one of the hallmark features of IBD-promotes chronic inflammation …
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