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Cerebral venous sinus thrombosis: an atypical presentation of Crohn's disease
Publication Year: 2025 Source: BMJ Case Rep PMID: 39986673
The rise in stroke cases in young people should be of major health concern, given the extensive compilation of underlying causes not traditionally seen in older people, and the impact and longevity of complications. Cerebral venous sinus thrombosis (CVST) is a rare form of stroke with female predominance. The clinical …
Encapsulated hesperetin modulates inflammatory responses in an in vitro intestinal immune co-culture model
Publication Year: 2025 Source: Food Res Int PMID: 39986769
In vitro cell models are an effective way to evaluate the biological activities of functional compounds. Hesperetin (HST) is a flavanone with various potential health-related benefits, and encapsulation improved its stability and bioavailability. This study aimed to investigate the anti-inflammatory effects of encapsulated HST using different delivery systems, including beta-cyclodextrin …
Position statement of the Spanish Society of Primary Care Physicians (SEMERGEN) and Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on the management of inflammatory bowel disease in Primary Care
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39986803 DOI: 10.1016/j.gastrohep.2024.502255
Primary Care is the first point of contact for most patients after the onset of symptoms of inflammatory bowel disease (IBD). Establishing an initial diagnostic process based on compatible symptoms and agreed criteria and referral pathways, depending on the degree of suspicion and the patient's situation, can reduce diagnostic delays. …
Intolerance of uncertainty and mental health in patients with IBD: the mediating role of maladaptive coping
Publication Year: 2025 Source: Sci Rep PMID: 39987257 DOI: 10.1038/s41598-025-86600-z
The aim of this study was to investigate the relationship between intolerance of uncertainty (IU) and mental health in patients with Inflammatory Bowel Disease (IBD), and to explore the mediating role of coping styles. A questionnaire was administered to adult patients with IBD, which included general demographic information, the Intolerance …
Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis
Publication Year: 2025 Source: Nat Commun PMID: 39987261 DOI: 10.1038/s41467-025-57211-z
Dysfunctional NF-kappaB signaling is critically involved in inflammatory bowel disease (IBD). We investigated the mechanism by which RIPK1 and TRADD, two key mediators of NF-kappaB signaling, in mediating intestinal pathology using TAK1 IEC deficient model. We show that phosphorylation of TRADD by TAK1 modulates RIPK1-dependent apoptosis. TRADD and RIPK1 act …
Identification of subtypes and biomarkers associated with disulfidptosis-related ferroptosis in ulcerative colitis
Publication Year: 2025 Source: Hereditas PMID: 39987439
BACKGROUND: Disulfidptosis and ferroptosis are different programmed cell death modes, which are closely related to the development of a variety of diseases, but the relationship between them and ulcerative colitis (UC) is still unclear. Therefore, our study aimed to explore the molecular subtypes and biomarkers associated with disulfidptosis-related ferroptosis (DRF) …
Uncovering the therapeutic potential of anti-tuberculoid agent Isoniazid in a model of microbial-driven Crohn's disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39987456
AIMS: TNFalpha has long stood as a hallmark feature of both inflammatory bowel disease and arthritis with its therapeutic potential demonstrated in neutralizing monoclonal antibody treatments such as Infliximab. Due to the high global burden of latent Mycobacterium tuberculosis (TB) infections, prior to receiving anti-TNF therapy, patients testing positive for …
Targeting ferroptosis in the treatment of ulcerative colitis by traditional Chinese medicine: A novel therapeutic strategies
Publication Year: 2025 Source: Phytomedicine PMID: 39987602 DOI: 10.1016/j.phymed.2025.156539
BACKGROUND: The incidence of ulcerative colitis (UC) has been rising rapidly in recent years, and there is currently no effective method to prevent its recurrence. Owing to its long treatment duration, difficulty in treatment, prolonged remission, and high costs, it has attracted global attention. Exploring safe, effective, and sustainable treatment …
A practical guide to dilating inflammatory bowel disease strictures
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 39987913 DOI: 10.1080/17474124.2025.2471873
INTRODUCTION: Stricturing Crohn's disease is a common phenotype and treatment aims to improve symptoms, prevent complications, assess for proximal bowel disease activity, and screen for upstream neoplasm. Management is challenging due to diagnostic limitations, stricture composition, and recurrence rate. AREAS COVERED: Categorizing a stricture as inflammatory or fibrotic is necessary …
Clinical effectiveness and safety of vedolizumab versus infliximab in biologic-naïve patients with ulcerative colitis: A comparative real-world multicentric observational study
Publication Year: 2025 Source: Gastroenterol Hepatol PMID: 39987969
OBJECTIVE: Vedolizumab (VDZ) and infliximab (IFX) are first-line therapies for moderate-to-severe ulcerative colitis (UC). Despite their widespread use, there are no direct comparative studies, and real-world data, particularly in Latin America, are limited. This study compared the effectiveness and safety of VDZ and IFX in biologic-naive UC patients. METHODS: This …
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