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Zatariamultiflora hydroalcoholic extract: A triple-blind randomized controlled trial on immune genes, inflammation, and ulcerative colitis symptoms
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39987994
ETHNOPHARMACOLOGICAL RELEVANCE: Zataria multiflora Boiss. (Shirazi thyme) is traditionally used for digestive disorders and inflammatory conditions. Despite its known anti-inflammatory, immunomodulatory, and antioxidant properties, there is limited clinical evidence on its efficacy for ulcerative colitis (UC). AIM OF THE STUDY: To evaluate the effectiveness of Zataria multiflora Boiss. (Z. multiflora) …
Process of empowerment in mothers of children with very-early-onset inflammatory bowel disease: a qualitative study
Publication Year: 2025 Source: Intest Res PMID: 39988446 DOI: 10.5217/ir.2024.00048
BACKGROUND/AIMS: Mothers of children with very-early-onset inflammatory bowel disease (VEO-IBD) face unique challenges; however, these challenges and their consequences have not been well described. This study clarified the experiences and processes of empowerment of mothers of children with VEO-IBD. METHODS: This study performed a qualitative inductive analysis using semi-structured interviews. …
Hirschsprung's disease may increase the incidence of inflammatory bowel disease through alterations in CA1
Publication Year: 2025 Source: Pediatr Res PMID: 39988713 DOI: 10.1038/s41390-025-03938-w
BACKGROUND: The role of Hirschsprung's disease (HSCR) for the development of inflammatory bowel disease (IBD) and the common pathogenesis of the diseases remains unclear. The objective is to investigate the relationship between HSCR and IBD. METHODS: In our study, the Mendelian randomization approach was employed to analyze the causal relationships. …
Oleanolic acid-based nanoparticles for the treatment of ulcerative colitis
Publication Year: 2025 Source: Nanomedicine (Lond) PMID: 39988882
AIM: This study aims to develop and assess the therapeutic potential of oleanolic acid nanoparticles (OA NPs) in treating ulcerative colitis (UC). MATERIALS & METHODS: OA NPs were synthesized using an emulsion solvent evaporation method, forming spherical nanoparticles with an average diameter of 138.1 nm. The nanoparticles were designed to …
Balancing Effective Treatments With Potential Threats: The Impact of Biologic Agent Use on Tuberculosis Development in Children With Chronic Inflammatory Disorders
Publication Year: 2025 Source: Int J Rheum Dis PMID: 39989306 DOI: 10.1111/1756-185X.70145
AIM: We aimed to investigate the frequency and clinical characteristics of tuberculosis in pediatric patients receiving both anti-TNF-alpha and other biological agents. MATERIALS AND METHODS: The data of 270 patients who used biological agents due to rheumatologic diseases and inflammatory bowel disease (IBD) and were followed between January 2021 and …
Matching-adjusted indirect comparisons of efficacy outcomes between etrasimod and ozanimod for moderately to severely active ulcerative colitis
Publication Year: 2025 Source: J Comp Eff Res PMID: 39989343
Aim: Etrasimod and ozanimod are selective sphingosine 1-phosphate receptor modulators targeting the S1P(1,4,5), and S1P(1,5) receptors, respectively, for the treatment of patients with moderately to severely active ulcerative colitis (UC). No head-to-head trial data exist between the two treatments. We compared these treatments indirectly using key efficacy outcomes from pivotal …
Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects
Publication Year: 2025 Source: FASEB J PMID: 39989432 DOI: 10.1096/fj.202402780R
Inflammatory bowel disease (IBD) is a multifactorial disease, and patients frequently experience extraintestinal manifestations affecting multiple sites. Causes of systemic inflammation remain poorly understood, but molecules originating from the intestine likely play a role, with microbial and host small molecules polarizing host immune cells towards a pro- or anti-inflammatory phenotype. …
Leucine-rich alpha-2 glycoprotein as a superior biomarker to C-reactive protein for detecting small bowel lesions in Crohn's disease
Publication Year: 2025 Source: World J Gastrointest Endosc PMID: 39989852
BACKGROUND: Achievement of endoscopic healing (EH) is significant in the clinical practice of inflammatory bowel disease as it is correlated with improved prognosis. Existing biomarkers, including C-reactive protein (CRP), have relatively low accuracy for predicting EH, especially in small intestinal lesions in Crohn's disease (CD); thus, noninvasive and more accurate …
Targeted delivery of Grem1 and IL-10 separately by mesenchymal stem cells effectively mitigates SETD2-deficient inflammatory bowel disease
Publication Year: 2025 Source: Theranostics PMID: 39990215 DOI: 10.7150/thno.105876
Rationale: Inflammatory bowel disease (IBD) is a relapsing and idiopathic disorder. The low therapeutic efficacy of IBD urgently prompts us to seek new treatment methods. Methods and Results: In this study, we report an adipose-derived mesenchymal stem cell (AT-MSC)-based treatment strategy in which AT-MSCs specifically deliver BMP inhibitor Grem1 and …
Orally Administrated Inulin-Modified Nanozymes for CT-Guided IBD Theranostics
Publication Year: 2025 Source: Int J Nanomedicine PMID: 39990289 DOI: 10.2147/IJN.S497558
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease with no clinical cure. Excessive production of reactive oxygen species (ROS) at the inflammatory sites leads to the onset and progression of IBD. And the current non-invasive imaging methods are not ideal for the diagnosis and monitoring of IBD. …
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