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The role of virtual reality in managing inflammatory bowel disease: a novel approach to bridging mental and physical health
Publication Year: 2025 Source: J Can Assoc Gastroenterol PMID: 39990506 DOI: 10.1093/jcag/gwae060
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is characterized by symptoms such as fatigue, abdominal pain, and diarrhoea, which may persist even when inflammation is controlled. These symptoms are further exacerbated by psychological stress, which may complicate disease management that involves the gut-brain axis-a bidirectional communication pathway …
Early life factors, diet and microbiome, and risk of inflammatory bowel disease
Publication Year: 2025 Source: J Can Assoc Gastroenterol PMID: 39990509 DOI: 10.1093/jcag/gwae039
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), result from a loss of immune tolerance to gut microbiota, leading to inflammation. Their incidence is increasing, especially in newly industrialized countries. The etiology is multifactorial, involving genetic, immune, microbiota, and environmental factors. Maternal microbiome changes during pregnancy …
Benchmarking in inflammatory bowel disease: lessons from Australia and New Zealand
Publication Year: 2025 Source: J Can Assoc Gastroenterol PMID: 39990512 DOI: 10.1093/jcag/gwae046
Inflammatory bowel disease (IBD) is a complex chronic disease estimated to affect almost 1% of the Western population, where proactive care has largely replaced a reactive approach. Whilst there have also been great strides in new care models and therapies, care quality, and outcomes are poorly known, leaving us designing …
What is first-line and what is second-line therapy in adult patients with moderate to severe Crohn's disease?
Publication Year: 2025 Source: J Can Assoc Gastroenterol PMID: 39990514
Crohn's disease, a chronic inflammatory bowel disease, necessitates a comprehensive treatment approach tailored to the individual's specific disease characteristics and overall health. Treatment strategies aim to induce and maintain remission, alleviate symptoms, normalize biomarkers, improve the endoscopic appearance of the intestine, and improve quality of life. Key therapeutic options include …
A practical approach to positioning therapies in ulcerative colitis
Publication Year: 2025 Source: J Can Assoc Gastroenterol PMID: 39990515
The therapeutic landscape of ulcerative colitis (UC) has undergone significant change over the last 2 decades. While there are multiple new therapies for the management of UC, long-term remission rates remain low, and this may be in part due to the difficulty of navigating a successful treatment strategy. In this …
Current approaches to studying human resting-state function in inflammatory bowel disease
Publication Year: 2025 Source: J Can Assoc Gastroenterol PMID: 39990517 DOI: 10.1093/jcag/gwae031
Crohn's disease and ulcerative colitis are 2 subtypes of Inflammatory Bowel Disease (IBD). The chronic, alternating periods of relapsing, and remitting inflammation of the gastrointestinal tract that underlie these diseases trigger a range of gut-related symptoms, in addition to being related to burdensome psychological and cognitive comorbidities. With advancing knowledge …
Inflammatory Bowel Disease in a Patient Returning from Colombia: Association with Dipeptidyl Peptidase 4 Inhibitor?
Publication Year: 2025 Source: Case Rep Gastroenterol PMID: 39990805 DOI: 10.1159/000543680
INTRODUCTION: Recent-onset colitis poses a diagnostic challenge, necessitating a thorough evaluation to identify potential infectious and non-infectious etiologies. We considered inflammatory bowel disease (IBD) secondary to dipeptidyl peptidase 4 (DPP-4) inhibitor-induced colitis. CASE PRESENTATION: This case report details the presentation and management of a patient with persistent dysentery, refractory to …
Acquired Ano-Rectal Sinuses and Fistulas Involving Genito-Urinary Structures in Men: A Case Series
Publication Year: 2025 Source: Cureus PMID: 39991385
Acquired ano-rectal fistulas and sinuses are frequently observed clinical conditions, with a higher prevalence in men. While these conditions typically remain confined to the ano-rectal region, the potential for involvement of nearby pelvic genito-urinary structures exists due to their anatomical closeness. Interestingly, such cases are rarely documented in medical literature. …
Comparative analysis of dominant gut microbiota in Inflammatory Bowel Disease patients and healthy individuals: A case-control study
Publication Year: 2025 Source: New Microbes New Infect PMID: 39991465 DOI: 10.1016/j.nmni.2025.101567
BACKGROUND: Chronic inflammation in the gut might be linked to microbiota dysbiosis. OBJECTIVE: This study aimed to investigate alterations in the gut microbiota composition of adult IBD patients compared to healthy controls. METHODS: This case-control study investigated the relationship between faecal microbiota composition and IBD in adults. Real-time qPCR analysis …
Effectiveness of biologics for endoscopic healing in patients with isolated proximal small bowel Crohn's disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 39991678
BACKGROUND: Endoscopic healing (EH) is a key therapeutic target in Crohn's disease (CD). Proximal small bowel (SB) lesions in patients with CD are associated with a significant risk of strictures and bowel resection. Assessing SB in patients with CD is necessary because of its significant therapeutic implications. The advent of …
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