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Primary sclerosing cholangitis: what is new in the therapeutic landscape
Publication Year: 2025 Source: Curr Opin Immunol PMID: 40683116
Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic liver disease affecting the intra- and extra-hepatic bile ducts, leading to progressive inflammation and fibrosis. Its pathogenesis is complex and involves genetic predisposition, environmental triggers, and their interaction through the gut-liver axis, mediated by the microbiota. To date, no approved therapies …
A Charge-Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40685690
The exacerbation and recurrence of inflammatory bowel disease (IBD) are closely related to the overactivation of the immune system and the destruction of the intestinal mucosa. Current small-molecule and biopharmaceutical therapies for IBD are often limited by off-target effects, low bioavailability, and poor treatment outcomes, leading to systemic side effects …
Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease
Publication Year: 2025 Source: Gut Microbes PMID: 40685618
The involvement of the intestinal microbiome in the pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC), is well-established. Bacteria interact with immune cells at sites of intestinal inflammation, but also in the CRC tumor microenvironment. We hypothesized that bacterial remnants translocate within peripheral blood mononuclear cells (PBMCs) into …
Genotype-Phenotype Correlation in TTC7A-Associated Gastrointestinal Defects and Immunodeficiency Syndrome 1
Publication Year: 2025 Source: Am J Med Genet A PMID: 40685546
Gastrointestinal defects and immunodeficiency syndrome 1 (GIDID1) is a rare autosomal recessive disorder caused by biallelic variants in TTC7A. GIDID1 is characterized by a broad clinical spectrum ranging from very early-onset inflammatory bowel disease (VEOIBD) to multiple intestinal atresia (MIA) with or without immunological manifestations. We report a patient born …
Dual-targeted therapy for the management of refractory Crohn's disease: a retrospective cohort study
Publication Year: 2025 Source: Clin Exp Med PMID: 40685491
Crohn's disease (CD) is a chronic relapsing autoimmune disease. Dual-targeted therapy (DTT) has been proven effective and safe in refractory inflammatory bowel disease (IBD), especially the combination of ustekinumab with vedolizumab (UST + VDZ). However, the efficacy and safety of DTT on refractory CD are still limited or insufficient. We …
A switch to infliximab may be more effective than ustekinumab following adalimumab pharmacodynamic failure in paediatric patients with Crohn's disease
Publication Year: 2025 Source: Dig Liver Dis PMID: 40685272
BACKGROUND: Loss of response (LOR) to anti-TNFalpha in patients with Crohn's disease (CD) is not uncommon. A particular challenge is pharmacodynamic LOR (inflammatory activity persisting despite adequate trough concentrations, TC). AIMS: To explore the outcomes of paediatric patients with CD following adalimumab pharmacodynamic failure. METHODS: We conducted a multi-centre retrospective …
Titanium dioxide nanoparticles drive the enhanced pro-inflammation response, worsening oxidative injure and gut microbiota dysbiosis in experimental colitis mice
Publication Year: 2025 Source: NanoImpact PMID: 40684984
With the wide use of titanium dioxide nanoparticles (TiO(2) NPs) in food products, inflammatory bowel disease (IBD) was inevitably to ingest it. In this work, we daily administered TiO(2) NPs to mice, followed by dextran sulfate sodium (DSS)-drinking for 7 days to obtain the colitis model. Excitedly, shorten colon length, …
Genistein maintains intestinal homeostasis in colitis mice via activating GPR30-Nrf2 signaling pathway
Publication Year: 2025 Source: J Nutr Biochem PMID: 40684867
Genistein (GEN) is a natural polyphenolic compound widely present in leguminous plants, which has many biological functions such as anti-inflammatory and antioxidant activities, and has attracted attention in the treatment of inflammatory bowel disease (IBD). However, the molecular mechanism underlying the beneficial effects of GEN in IBD remains unclear. Here, …
Contraceptive use among women with inflammatory bowel disease: An updated systematic review
Publication Year: 2025 Source: Contraception PMID: 40684829
BACKGROUND: Hormonal contraceptive use by women with inflammatory bowel disease (IBD) might affect risk of adverse outcomes or contraceptive effectiveness. Our objective was to update a previous systematic review on the safety and effectiveness of contraceptive use among women with IBD. METHODS: We searched multiple databases from inception through July …
Addressing bias in biomarker discovery for inflammatory bowel diseases: A multi-faceted analytical approach
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40684706
Xiang-Guang et al. investigate the identification of novel biomarkers linked to M1 macrophage infiltration in inflammatory bowel diseases (IBD). Utilizing advanced bioinformatics and machine learning techniques, the researchers developed predictive models and employed the SHAP algorithm to assess feature importance, revealing that the top ten features corresponded exclusively to host …
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