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Pre-vaccination immune markers predict response to BNT162b2 mRNA vaccine in vulnerable groups - The CONVERS project, report from a pediatric tertiary hospital
Publication Year: 2025 Source: Vaccine PMID: 39947073
BACKGROUND: Whereas several studies have demonstrated the long-term immunogenicity of BNT162b2 vaccine in healthy adults, little evidence was provided in vulnerable populations (VPs) with generally low ability to respond to immunizations. We aimed to identify pre-vaccination immune phenotype and transcriptional signatures in B and T-cell subsets associated with immune response …
A meta-analysis of the gut microbiome in inflammatory bowel disease patients identifies disease-associated small molecules
Publication Year: 2025 Source: Cell Host Microbe PMID: 39947133 DOI: 10.1016/j.chom.2025.01.002
Gut microbiome changes have been associated with several human diseases, but the molecular and functional details underlying these associations remain largely unknown. Here, we performed a meta-analysis of small molecule biosynthetic gene clusters (BGCs) in metagenomic samples of the gut microbiome from inflammatory bowel disease (IBD) patients and matched healthy …
Immune response of chickens with aIBDV infection by high-throughput sequencing in chickens
Publication Year: 2025 Source: Microb Pathog PMID: 39947357 DOI: 10.1016/j.micpath.2025.107376
Infectious bursal disease (IBD) can result in significant immunosuppression and bursal damage in 3-6 week chickens. To investigate the role of important genes from chicken during IBD virus (IBDV) infection, Jinghong laying hens were used to clarify the pathways of immune response. The transcriptional profiles of cecal tonsil of chickens …
Fuzi Lizhong Pill inhibited inflammatory response and promoted colon mucosal healing in dextran sulfate sodium-induced ulcerative colitis mice by down-regulating PI3K/AKT/NF-κB signaling pathway
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39947366
ETHNOPHARMACOLOGICAL RELEVANCE: Fuzi Lizhong Pill (FLP), a traditional Chinese herbal formula, has been historically used for treating gastrointestinal disorders characterized by cold deficiency patterns. Its application in ulcerative colitis (UC) stems from its warming and tonifying properties. AIM OF THE STUDY: To evaluate the efficacy of FLP in the treatment …
Microplastic accumulation in fibrotic intestinal tissue and mesenteric adipose tissue in Crohn's disease patients
Publication Year: 2025 Source: Environ Res PMID: 39947377
Crohn's disease (CD) patients exhibit heightened vulnerability to environmental triggers. However, the impact of microplastics (MPs) on CD remains unexplored. This study investigates MPs in ileal segments and mesenteric adipose tissue from CD patients. We recruited paired involved and adjacent uninvolved ileal segments, along with attached creeping fat (CF) and …
DS0384 Alleviates Necrotizing Enterocolitis: Secretes N-carbamyl glutamic Acid and Participates in Lipid Metabolism and Lipid Peroxidation Processes
Publication Year: 2025 Source: J Microbiol Biotechnol PMID: 39947675
Necrotizing enterocolitis (NEC) is a life-threatening inflammatory bowel disease linked to gut microbiome dysbiosis. This study evaluates the efficacy of Limosilactobacillus reuteri strain DS0384, which secretes N-carbamyl glutamic acid (NCG), in modulating lipid peroxidation and inflammatory pathways in NEC. After pretreatment with DS0384, NEC mouse model was induced by gavage …
Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice
Publication Year: 2025 Source: J Microbiol Biotechnol PMID: 39947703
Ulcerative colitis (UC) is a type of inflammatory bowel disease arising from numerous factors, while UC patients face insufficient treatment options and a high incidence of adverse reactions to the current therapies. As a functional food additive, hyaluronic acid plays a certain role in intestinal repair. In this study, we …
Disulfidptosis links the pathophysiology of ulcerative colitis and immune infiltration in colon adenocarcinoma
Publication Year: 2025 Source: Sci Rep PMID: 39948102
Ulcerative colitis (UC), a chronic inflammatory bowel disease, significantly increases the risk of colon adenocarcinoma (COAD). Disulfidptosis, a novel form of programmed cell death, has been implicated in various diseases, including UC. This study investigates the expression of disulfidptosis-related genes, particularly CD2AP and MYH10, in UC and COAD. Through analysis …
Delayed Corticosteroid Treatment for Patients Requiring Hospitalization for Acute Inflammatory Bowel Disease Exacerbations Increases Length of Stay and Risk for Surgery in Crohn's Disease
Publication Year: 2025 Source: Dig Dis Sci PMID: 39948278 DOI: 10.1007/s10620-025-08907-1
BACKGROUND: While corticosteroids are not recommended for maintenance of remission in inflammatory bowel disease (IBD), they are quite effective for the induction of remission for both Crohn's disease (CD) and ulcerative colitis (UC). We aimed to evaluate if a delay in starting corticosteroids after presentation to the hospital for an …
Epidemiology and clinical outcomes of hospitalized Hispanic patients with IBD: results of a large national cohort study
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 39948305 DOI: 10.1007/s00384-025-04822-z
INTRODUCTION: Inflammatory bowel disease (IBD) has historically been seen as predominantly affecting non-Hispanic Whites (NHW). Hispanics are the largest minority group in the USA, yet they remain grossly underrepresented in studies of IBD. With this study, we aimed to better understand the epidemiology of hospitalized Hispanic patients with IBD in …
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