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Upadacitinib in Autoimmune Enteropathy-A Case Report
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39951032
No Abstract
Deep Sequencing of Crohn's Disease Lamina Propria Phagocytes Identifies Pathobionts and Correlates With Pro-Inflammatory Gene Expression
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39951038 DOI: 10.1093/ibd/izae316
BACKGROUND: Crohn's disease (CD) is characterized by an inflammatory response to gut microbiota. Macrophages and dendritic cells play an active role in CD inflammation. Specific microbiota have been implicated in the pathogenesis of ileal CD. We investigated the phagocyte-associated microbiome using an unbiased sequencing approach to identify potential pathobionts and …
Feasibility and usefulness of the elongation of ileocolic pedicle with extended ileal resection on secure anastomosis after laparoscopic restorative proctocolectomy: a retrospective observational study
Publication Year: 2025 Source: Tech Coloproctol PMID: 39951184
PURPOSE: Tension-free ileal pouch-anal anastomosis (IPAA) in restorative proctocolectomy (RPC) for ulcerative colitis (UC) and familial adenomatous polyposis (FAP) is important for avoiding anastomotic complications. We have employed the elongation of ileocolic pedicle (ICP) with extended ileal resection as one of the mesenteric-lengthening techniques. In this study, we examined the …
A biodegradable capacitive-coupling neurostimulator for wireless electroceutical treatment of inflammatory bowel diseases
Publication Year: 2025 Source: Sci Adv PMID: 39951521 DOI: 10.1126/sciadv.adu5887
Electroceuticals based on peripheral nerve stimulation offer promising treatment for refractory inflammatory diseases such as inflammatory bowel diseases (IBDs). For pediatric IBD (PIBD) patients, wireless, biodegradable miniaturized bioelectronic devices are crucial to prevent neural damage and support neural development during and after therapy. Here we demonstrate a battery-free, miniaturized neurostimulator …
Dichotomous effects of Galectin-9 in disease modulation in murine models of inflammatory bowel disease
Publication Year: 2025 Source: Biomed Pharmacother PMID: 39951917 DOI: 10.1016/j.biopha.2025.117902
Inflammatory bowel disease (IBD) is a multifaceted disease characterised by compromised integrity of the epithelial barrier, the gut microbiome, and mucosal inflammation. While leukocyte recruitment and infiltration into intestinal tissue are well-studied and targeted in clinical practice, the role of galectins in modulating mucosal immunity remains underexplored. Galectins, a family …
Accelerated biological aging and risk of inflammatory bowel disease: A prospective study from 401,013 participants
Publication Year: 2025 Source: J Nutr Health Aging PMID: 39952016 DOI: 10.1016/j.jnha.2025.100505
OBJECTIVES: Relationship between biological aging and inflammatory bowel disease (IBD) remains unclear. We aimed to explore the associations of biological age and genetic predisposition with IBD and the predictive ability. METHODS: Biological age and genetic predisposition were measured by PhenoAge and the polygenic risk score (PRS), respectively. The hazard ratio …
Exhaustion profile on classical monocytes after LPS stimulation on Crohn's disease patients
Publication Year: 2025 Source: Hum Immunol PMID: 39952081
Crohn's disease is a type of inflammatory bowel disease that leads to symptoms such as diarrhea, abdominal pain, weight loss, and increased risk of developing tumors. The immune system plays a vital role in the gastrointestinal tract by maintaining tolerance to commensal antigens and food. However, in Crohn's disease, this …
Establishment of a National Surgical Tissue Biobank for Pediatric Crohn's Disease: An Implementation Feasibility Study
Publication Year: 2025 Source: J Pediatr Surg PMID: 39952194
BACKGROUND: Crohn's disease (CD) is a lifelong gastrointestinal inflammatory condition that often requires surgery, particularly for patients diagnosed in childhood. CD has been linked to a combination of microbial, genetic, and environmental factors, but pathogenesis remains unknown. We outline a framework for multicenter surgical biobanking across a large geographic area, …
Research progress on edible mushroom polysaccharides as a novel therapeutic strategy for inflammatory bowel disease
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39952533 DOI: 10.1016/j.ijbiomac.2025.140994
Inflammatory bowel disease (IBD) is a complex condition linked to the gut microbiota, host metabolism, and the immune system. Edible mushroom polysaccharides (EMPs) are gaining attention for their benefits, particularly as prebiotics that help balance gut microbial, a key factor in IBD. With their scalable production, diverse hydrophilic properties, and …
Faecal calprotectin as a non-invasive marker of Crohn's disease in anal fistulas
Publication Year: 2025 Source: Colorectal Dis PMID: 39952904 DOI: 10.1111/codi.70026
AIM: Faecal calprotectin (FC) is a noninvasive marker that reflects intestinal inflammation with good sensitivity. A prior study indicated that FC values above 150 mug/g could distinguish between anal fistulas (AF) of cryptoglandular or Crohn's disease (CD) origin. It is hypothesized as a useful triage test to rule out CD …
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