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Exploring the potential mechanism of B-phycoerythrin on DSS-induced colitis and colitis-associated bone loss based on network pharmacology, molecular docking, and experimental validation
Publication Year: 2025 Source: Sci Rep PMID: 39953092
B-phycoerythrin (B-PE), a pigment protein, has found extensive applications in the food, pharmaceutical, and cosmetic industries. However, the effects and potential mechanisms of B-PE on colitis and colitis-associated bone loss remain unclear. Thus, the aim of this study was to investigate the pharmacological mechanisms of B-PE against colitis and colitis-associated …
IBS and IBD-One Letter, Much Pain, Few Treatments
Publication Year: 2025 Source: Dig Dis Sci PMID: 39953184 DOI: 10.1007/s10620-025-08892-5
No Abstract
Diagnostic accuracy and cut-off values of serum leucine-rich alpha-2 glycoprotein for Crohn's disease activity in the small bowel
Publication Year: 2025 Source: J Gastroenterol PMID: 39953247
BACKGROUND: Small bowel (SB) lesions in Crohn's disease (CD) are often asymptomatic despite being highly active. Fecal calprotectin (FC) is the most widely used biomarker of CD activity, but its drawbacks include a large intra-individual sample variability and the burden of collecting stool samples. Meanwhile, serum leucine-rich alpha-2 glycoprotein (LRG) …
The Impact of Radiation Proctopathy on Secondary-Primary Colorectal Cancer in Patients with Prostate Cancer
Publication Year: 2025 Source: J Gastrointest Cancer PMID: 39954024
PURPOSE: We designed this study to evaluate the relationship between radiation proctopathy (RP) and the risk of colon and rectal cancer in prostate cancer patients. METHODS: This is a retrospective cohort study evaluating patients with prostate cancer who received pelvic radiation therapy between January 2004 and January 2024. The study …
A case-control comparison of alopecia areata and inflammatory bowel disease
Publication Year: 2025 Source: Arch Dermatol Res PMID: 39954115
No Abstract
Concurrent pediatric eosinophilic esophagitis and inflammatory bowel disease: a longitudinal single center case‒control study and literature review
Publication Year: 2025 Source: World J Pediatr PMID: 39954207
No Abstract
Anemia in inflammatory bowel disease-A comprehensive review
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 39954228 DOI: 10.1007/s12664-024-01735-7
Anemia is a frequent complication in inflammatory bowel disease (IBD) patients. The etiology is multifactorial, with iron deficiency and anemia of chronic disease being the main reasons. Other causes include vitamin B(12) and folate deficiency, hemolytic anemia and medications such as azathioprine and sulfasalazine. Apart from physical symptoms, it is …
Letter: The Hidden Truth of IBD Risk-From Antibiotics to Environmental Factors
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39954249 DOI: 10.1111/apt.18517
No Abstract
Cost-Effectiveness Analysis of Upadacitinib in Patients With Moderately to Severely Active Ulcerative Colitis in Greece
Publication Year: 2025 Source: Value Health Reg Issues PMID: 39954537
OBJECTIVES: This study aimed to evaluate the cost-effectiveness of upadacitinib in patients with moderately to severely active ulcerative colitis (UC), who have had an inadequate response, lost response, or were intolerant to either conventional therapy (bio-naive) or a biologic agent (bio-exposed), in Greece. METHODS: A cost-effectiveness model, consisting of an …
The VIVID-1 study: A novel methodological approach provides further evidence of efficacy of selective IL-23 inhibition in Crohn's disease
Publication Year: 2025 Source: Med PMID: 39954670
The VIVID-1 study is a phase 3 randomized controlled trial assessing the efficacy and safety of mirikizumab in moderate-to-severe active Crohn's disease.(1) The study confirms the advantage of selective IL-23 inhibition, while the treat-through design and the choice of composite coprimary endpoints represent an innovative strategy in conducting clinical trials …
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