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Inflammatory bowel disease in south Asia: a scoping review
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 39954693 DOI: 10.1016/S2468-1253(24)00341-8
Inflammatory bowel disease (IBD) is rising at an alarming rate in south Asia and there is a paucity of data on IBD in this region. For this scoping review, we conducted a systematic search to identify all observational and interventional studies on IBD in south Asia. Of 14 924 potentially …
Quercus infectoria galls mitigates colitis in mice through alleviating mucosal barrier impairment and suppressing inflammatory factors
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39954828
ETHNOPHARMACOLOGICAL RELEVANCE: Xipayi Kuijie'an herbal enema preparation, a traditional Uyghur medicinal preparation derived from Quercus infectoria galls (QIG), has been clinically employed at Xinjiang Uyghur Medical Hospital for ulcerative colitis (UC) management. Despite its well-documented therapeutic efficacy, the precise mechanisms underlying its pharmacological actions remain poorly understood. AIM OF STUDY: …
Endogamy and high prevalence of deleterious mutations in India: evidence from strong founder events
Publication Year: 2025 Source: J Genet Genomics PMID: 39955025 DOI: 10.1016/j.jgg.2025.02.001
Founder events influence recessive diseases in highly endogamous populations. Several Indian populations have experienced significant founder events due to strict endogamy. However, the clinical implications of it remain underexplored. Therefore, we perform whole-exome sequencing of 281 individuals from four South Indian populations, characterized by high IBD scores. Our study reveals …
Identifying robust biomarkers for the diagnosis and subtype distinction of inflammatory bowel disease through comprehensive serum metabolomic profiling
Publication Year: 2025 Source: Sci Rep PMID: 39955397 DOI: 10.1038/s41598-025-90160-7
Inflammatory Bowel Disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), requires a combination of procedures and tests in diagnosis and discrimination. This study aimed to delineate specific serum metabolomic biomarkers that diagnose IBD and differentiate IBD subgroups. Serum samples and clinical metadata of the participants, IBD patients and Normal …
Gene expression regulation and polyadenylation in ulcerative colitis via long-chain RNA sequencing
Publication Year: 2025 Source: BMC Genomics PMID: 39955510
BACKGROUND: Ulcerative colitis (UC) is an immune-mediated chronic intestinal disease, with a pathogenesis that remains incompletely understood. The purpose of this study is to analyze the difference of gene expression between UC patients and healthy controls using Oxford Nanopore Technology's long-read RNA sequencing (ONT-RNA-seq) and to explore how alternative polyadenylation …
An extensively hydrolysed protein-based extruded diet in the treatment of dogs with chronic enteropathy and at least one previous diet-trial failure: a pilot uncontrolled open-label study
Publication Year: 2025 Source: BMC Vet Res PMID: 39955592
BACKGROUND: Canine chronic enteropathies (CE) are a group of disorders defined by persistent or recurrent clinical signs of gastrointestinal disease without a primary neoplastic, metabolic, parasitic, or other infectious cause. In this prospective, multicentre, uncontrolled, open-label study, a commercial dry diet with a protein source of extensively hydrolysed poultry feather …
Electroacupuncture at ST36 Relieves Visceral Hypersensitivity Based on the Vagus-Adrenal Axis in the Remission Stage of Ulcerative Colitis
Publication Year: 2025 Source: Neuromodulation PMID: 39955664
BACKGROUND AND AIMS: Although electroacupuncture (EA) at ST36 has been shown to alleviate visceral hypersensitivity in rats with ulcerative colitis (UC), the exact mechanism remains unknown. This study aims to investigate whether EA can effectively inhibit the activity of enteric glial cells (EGCs) through the adrenergic antiinflammatory pathway and thereby …
Implications of nociceptor receptors and immune modulation: emerging therapeutic targets for autoimmune diseases
Publication Year: 2025 Source: Inflammopharmacology PMID: 39955696 DOI: 10.1007/s10787-025-01653-w
Chronic painful autoimmune disorders such as multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) induce significant discomfort. They are defined by persistent inflammation and immune-mediated tissue injury. The activation and sensitisation of nociceptors, mutated in various disorders, are fundamental components contributing to the pain experienced in these …
Unravelling exosome paradigm: Therapeutic, diagnostic and theranostics application and regulatory consideration
Publication Year: 2025 Source: Life Sci PMID: 39956185 DOI: 10.1016/j.lfs.2025.123472
No Abstract
Lithospermic acid alleviates oxidative stress and inflammation in DSS-induced colitis through Nrf2
Publication Year: 2025 Source: Eur J Pharmacol PMID: 39956261
Lithospermic acid (LA), a plant-derived polycyclic phenolic carboxylic acid, is known for its strong anti-inflammatory and antioxidant effects. However, its effects have not yet been studied in ulcerative colitis (UC). This study aimed to assess the protective effects of LA in UC and investigate its potential mechanisms of action. Our …
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