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Dysplasia in Pediatric Patients with Inflammatory Bowel Disease Shows Distinct Clinicopathologic Features Compared With that in Adult Patients
Publication Year: 2025 Source: Mod Pathol PMID: 39956269 DOI: 10.1016/j.modpat.2025.100735
Due to its rarity, there is limited information on the clinicopathologic features of dysplasia in pediatric patients with inflammatory bowel disease (IBD). The existing surveillance guidelines for these patients do not include dysplasia as a potential risk factor for colorectal cancer, and there is no clear guidance on the optimal …
A Mediterranean Diet for Crohn's Disease: Embracing Colorful Diversity to Improve the Microbiome
Publication Year: 2025 Source: Gastroenterology PMID: 39956335
No Abstract
Cardiovascular safety of Janus kinase inhibitors in inflammatory bowel disease: a systematic review and network meta-analysis
Publication Year: 2025 Source: Ann Med PMID: 39838595 DOI: 10.1080/07853890.2025.2455536
BACKGROUND AND OBJECTIVE: Janus kinase (JAK) inhibitors (JAKinibs) are effective for inflammatory bowel disease (IBD), but their cardiovascular safety is inconclusive. We aim to assess the cardiovascular risks associated with JAKinibs in IBD patients. PATIENTS AND METHODS: Systematic searches of seven databases and ClinicalTrials.gov from inception to February 2024 were …
Understanding fatigue among Japanese patients with inflammatory bowel disease: insights from international comparisons and meta-analysis
Publication Year: 2025 Source: Intest Res PMID: 39838746 DOI: 10.5217/ir.2024.00145
BACKGROUND/AIMS: Fatigue is a common symptom in patients with inflammatory bowel disease (IBD). The Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale has demonstrated reliability and validity in assessing fatigue in patients with IBD and is used worldwide. This study aimed to examine the current state of fatigue among Japanese …
OMIP-110: A 37-Color Spectral Flow Cytometric Panel to Assess Transcription Factors and Chemokine Receptors in Human Intestinal Lymphoid Cells
Publication Year: 2025 Source: Cytometry A PMID: 39838760 DOI: 10.1002/cyto.a.24914
We have developed a 37-color spectral flow cytometry panel to assess the phenotypical differentiation of innate and adaptive immune lymphoid subsets within human intestinal tissue. In addition to lineage markers for identifying innate lymphoid cells (ILC), TCRgammadelta, MAIT (mucosal-associated invariant T), natural killer (NK), CD4(+) and CD8(+) T cells, we …
Comment on 'Experience of Diet in Patients With Inflammatory Bowel Disease: A Thematic Synthesis of Qualitative Studies'
Publication Year: 2025 Source: J Clin Nurs PMID: 39838859
No Abstract
Meeting report - Alpine desmosome disease meeting 2024: advances and emerging topics in desmosomes and related diseases
Publication Year: 2025 Source: J Cell Sci PMID: 39838950
Desmosomes are adhesive cell contacts abundant in tissues exposed to mechanical strain, such as the stratified and simple epithelia of the epidermis and mucous membranes, as well as the myocardium. Besides their role in mechanical cell cohesion, desmosomes also modulate pathways important for tissue differentiation, wound healing and immune responses. …
Development of a Second-Generation, In Vivo Chemical Probe for PIKfyve
Publication Year: 2025 Source: J Med Chem PMID: 39838960
We optimized our highly potent and cell-active chemical probe for phosphatidylinositol-3-phosphate 5-kinase (PIKfyve), SGC-PIKFYVE-1, resulting in compounds with improved potency and demonstrated in vivo stability. Use of an in-cell, kinome-wide selectivity panel allowed for confirmation of excellent in-cell selectivity of our lead compound, 40, and another promising analogue, 46. Evaluation …
Prone Transpsoas Lumbar Interbody Fusion for Degenerative Disc Disease
Publication Year: 2025 Source: JBJS Essent Surg Tech PMID: 39839241
BACKGROUND: Prone transpsoas lumbar interbody fusion (PTP) is a newer technique to treat various spinal disc pathologies. PTP is a variation of lateral lumbar interbody fusion (LLIF) that is performed with the patient prone rather than in the lateral decubitus position. This approach offers similar benefits of lateral spinal surgery, …
Plasma Epstein-Barr Virus DNA load for diagnostic and prognostic assessment in intestinal Epstein-Barr Virus infection
Publication Year: 2025 Source: Front Cell Infect Microbiol PMID: 39839261 DOI: 10.3389/fcimb.2024.1526633
BACKGROUND: The prospective application of plasma Epstein-Barr virus (EBV) DNA load as a noninvasive measure of intestinal EBV infection remains unexplored. This study aims to identify ideal threshold levels for plasma EBV DNA loads in the diagnosis and outcome prediction of intestinal EBV infection, particularly in cases of primary intestinal …
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