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Differential pathological changes in colon microenvironments in acute and chronic mouse models of inflammatory bowel disease

Publication Year: 2025 Source: Anim Cells Syst (Seoul) PMID: 39839656

Inflammatory bowel disease is a chronic condition characterized by inflammation of the gastrointestinal tract, resulting from an abnormal immune response to normal stimuli, such as food and intestinal flora. Since the etiology of this disease remains largely unknown, murine models induced by the consumption of dextran-sodium sulfate serve as a …

Selenium in cancer management: exploring the therapeutic potential

Publication Year: 2025 Source: Front Oncol PMID: 39839762

No Abstract

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

Publication Year: 2025 Source: World J Gastroenterol PMID: 39839900

BACKGROUND: Mucosal healing (MH) is the major therapeutic target for Crohn's disease (CD). As the most commonly involved intestinal segment, small bowel (SB) assessment is crucial for CD patients. Yet, it poses a significant challenge due to its limited accessibility through conventional endoscopic methods. AIM: To establish a noninvasive radiomic …

Controversies in fecal incontinence

Publication Year: 2025 Source: World J Gastroenterol PMID: 39839905

Fecal incontinence is a common condition that can significantly impact patients' quality of life. Obstetric anal sphincter injury and anorectal surgeries are common etiologies. Endoanal ultrasound and anorectal manometry are important diagnostic tools for evaluating patients. There are various treatment options, including diet, lifestyle modifications, drugs, biofeedback therapy, tibial and …

PANoptosis in intestinal epithelium: its significance in inflammatory bowel disease and a potential novel therapeutic target for natural products

Publication Year: 2025 Source: Front Immunol PMID: 39840043 DOI: 10.3389/fimmu.2024.1507065

The intestinal epithelium, beyond its role in absorption and digestion, serves as a critical protective mechanical barrier that delineates the luminal contents and the gut microbiota from the lamina propria within resident mucosal immune cells to maintain intestinal homeostasis. The barrier is manifested as a contiguous monolayer of specialized intestinal …

A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals

Publication Year: 2025 Source: Front Immunol PMID: 39840057

No Abstract

Decursinol angelate relieves inflammatory bowel disease by inhibiting the ROS/TXNIP/NLRP3 pathway and pyroptosis

Publication Year: 2025 Source: Front Pharmacol PMID: 39840084 DOI: 10.3389/fphar.2024.1520040

INTRODUCTION: Despite evidence of the efficacy of decursinol angelate (DA), a prescription medication derived farom traditional Chinese medicine, in alleviating inflammatory bowel disease (IBD), the precise mechanisms behind its action remain unclear. METHODS: Lipopolysaccharides (LPS) and dextran sodium sulfate (DSS) induction were used as in vitro and in vivo models …

Microfluidic organ-on-chip systems for periodontal research: advances and future directions

Publication Year: 2025 Source: Front Bioeng Biotechnol PMID: 39840127

No Abstract

SOCS1 deficiency-crossroads of autoimmunity and autoinflammation-two case reports

Publication Year: 2025 Source: Front Pediatr PMID: 39840313

No Abstract

Resolution of cuffitis after removal surgical staple from ileal pouch-anal anastomosis

Publication Year: 2025 Source: Gastroenterol Rep (Oxf) PMID: 39840326 DOI: 10.1093/gastro/goaf002

No Abstract

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