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Chronic enteropathy in dogs affects the quality of life in both dogs and their owners-are veterinarians proficient in handling the caregiver burden?
Publication Year: 2025 Source: Front Vet Sci PMID: 39840341
No Abstract
Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis-Associated Colorectal Cancer
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39840505
Patients with ulcerative colitis (UC) have a higher risk of developing colorectal cancer (CRC), however, the metabolic shifts during the UC-to-CRC transition remain elusive. In this study, an AOM-DSS-induced three-stage colitis-associated colorectal cancer (CAC) model is constructed and targeted metabolomics analysis and pathway enrichment are performed, uncovering the metabolic changes …
Plasma glucagon-like peptide-2 in cats with chronic enteropathies
Publication Year: 2025 Source: J Feline Med Surg PMID: 39840661
OBJECTIVES: The objective of this study was to compare plasma glucagon-like peptide-2 (GLP-2) concentrations in cats with chronic enteropathies (CE) with those of healthy cats. METHODS: Nineteen client-owned cats with a histopathologic diagnosis of either idiopathic chronic enteropathy (CIE) or low-grade lymphoma and six healthy client-owned cats were enrolled in …
Mortality in Autoimmune Liver Disease in Sweden: A Population-Based Cohort Study of 9,654 Patients
Publication Year: 2025 Source: Liver Int PMID: 39840802
BACKGROUND/AIMS: Epidemiological data on mortality in autoimmune liver diseases (AILDs) are scarce. We examined all-cause and cancer-related mortality in individuals with AILD from Sweden. METHODS: We identified 9654 individuals with AILD (3342 with autoimmune hepatitis (AIH), 3751 with primary biliary cholangitis (PBC), and 2561 with primary sclerosing cholangitis (PSC)) using …
The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8(+) T cells in mice
Publication Year: 2025 Source: mSystems PMID: 39840995 DOI: 10.1128/msystems.01567-24
The gut microbiota is closely associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC). Probiotics such as Clostridium butyricum (CB) or Akkermansia muciniphila (AKK) have the potential to treat inflammatory bowel disease (IBD) or colorectal cancer (CRC). However, research on the combined therapeutic effects and immunomodulatory mechanisms of CB …
Akkermansia muciniphila relieves inflammatory response in DSS-induced ulcerative colitis in mice through regulating macrophage polarization via SCFAs-SLC52A2/FFAR2 pathway
Publication Year: 2025 Source: Naunyn Schmiedebergs Arch Pharmacol PMID: 39841217
Ulcerative colitis (UC) remains an intractable and relapsing disease featured by intestinal inflammation. The anti-UC activity of Akkermansia muciniphila (AKK), an intestinal microorganism, has been widely investigated. The current work is to explore the impacts of AKK on UC and its possible reaction mechanism. In vivo UC model was induced …
PSC and colitis: A complex relationship
Publication Year: 2025 Source: Hepatology PMID: 39841598 DOI: 10.1097/HEP.0000000000001236
Primary sclerosing cholangitis is one of the most challenging conditions in hepatology, and due to our limited understanding of its pathogenesis, no causal therapies are currently available. While it was long assumed that a minority of people with IBD also develop PSC, which is sometimes labeled an extraintestinal manifestation of …
Peripartum Mental Illness in Mothers With Multiple Sclerosis and Other Chronic Diseases in Ontario, Canada
Publication Year: 2025 Source: Neurology PMID: 39841953 DOI: 10.1212/WNL.0000000000210170
BACKGROUND AND OBJECTIVES: Peripartum mood and anxiety disorders constitute the most frequent form of maternal morbidity in the general population, but little is known about peripartum mental illness in mothers with multiple sclerosis (MS). We compared the incidence and prevalence of peripartum mental illness among mothers with MS, epilepsy, inflammatory …
Clinical diagnosis and management of inflammatory bowel disease in a rabbit (Oryctolagus cuniculus)
Publication Year: 2025 Source: J Am Vet Med Assoc PMID: 39842100
No Abstract
Toll-like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5-hydroxytryptaminergic neurotransmission
Publication Year: 2025 Source: Br J Pharmacol PMID: 39842456 DOI: 10.1111/bph.17439
BACKGROUND AND PURPOSE: Inflammatory bowel disease (IBD) patients display genetic polymorphisms in toll-like receptor 4 (TLR4) genes, contributing to dysregulate enteric nervous system (ENS) circuits with increased levels of 5-HT and alteration of the neuroimmune crosstalk. In this study, we investigated the impact of TLR4 signalling on mouse ENS dysfunction …
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