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The gut microbiota predicts and time-restricted feeding delays experimental colitis
Publication Year: 2025 Source: Gut Microbes PMID: 39843997 DOI: 10.1080/19490976.2025.2453019
The etiology of inflammatory bowel disease (IBD) remains unclear, treatment options unsatisfactory and disease development difficult to predict for individual patients. Dysbiosis of the gastrointestinal microbiota and disruption of the biological clock have been implicated and studied as diagnostic and therapeutic targets. Here, we examine the relationship of IBD to …
Structural equation modeling of the impact of disease activity on inflammatory bowel disease control: the mediating roles of self-efficacy and self-management behaviors
Publication Year: 2025 Source: BMC Gastroenterol PMID: 39844024 DOI: 10.1186/s12876-025-03623-6
BACKGROUND: Maintaining effective disease control in patients with inflammatory bowel disease (IBD) is both a significant goal and challenge. Drawing on the Common-Sense Model of Self-Regulation (CSM) and related research, this study investigates how IBD activity status influences disease control through both direct and indirect pathways. METHODS: A cross-sectional survey …
Adhesive polyelectrolyte coating through UV-triggered polymerization on PLGA particles for enhanced drug delivery to inflammatory intestinal mucosa
Publication Year: 2025 Source: J Nanobiotechnology PMID: 39844269
Administering medication precisely to the inflamed intestinal sites to treat ulcerative colitis (UC), with minimized side effects, is of urgent need. In UC, the inflammation damaged mucosa contains a large number of amino groups which are positively charged, providing new opportunities for drug delivery system design. Here, we report an …
Obesity Is Associated With Worsened Outcomes in Patients With Ulcerative Colitis on Advanced Therapies: A Propensity Matched Cohort Study From the U.S
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39844347 DOI: 10.1111/apt.18513
BACKGROUND: Obesity has been linked to a more severe phenotype in patients with ulcerative colitis (UC). AIM: To evaluate the impact of obesity on outcomes of advanced therapies in UC. METHODS: We conducted a retrospective cohort study utilising the TriNetX database comparing the composite score of corticosteroid use, change in …
Research Prospects for Necroptosis in Inflammatory Diseases: A Bibliometric Analysis
Publication Year: 2025 Source: Curr Med Chem PMID: 39844404
BACKGROUND: Necroptosis is a modifiable form of cell death mainly dependent on RIPK3 and MLKL. The association between necroptosis and inflammation has been a key focus of research. An increasing number of studies have shown that necroptosis plays an important role in inflammatory diseases, such as inflammatory bowel disease. METHODS: …
A Novel Rat Model for Inflammatory Gut-Brain Interactions in Parkinson's Disease
Publication Year: 2025 Source: Eur J Neurosci PMID: 39844519
Gut inflammation is a salient prodromal feature of Parkinson's disease (PD) implicated in pathologic processes leading to nigrostriatal dopaminergic degeneration. However, existing rodent models of PD are suboptimal for investigating the interaction between gut inflammation and neuropathology. This study aimed to develop a rat model of PD in which gut …
A Parasite That Should not be Neglected in Patients with Ulcerative Colitis: Entamoeba histolytica
Publication Year: 2025 Source: Turkiye Parazitol Derg PMID: 39844664
OBJECTIVE: To determine the prevalence of amoebiasis, which has been neglected in recent years according to the World Health Organization, in ulcerative colitis patients and investigate the relationship between amoebiasis and ulcerative colitis. METHODS: The study included 150 individuals, including 100 ulcerative colitis patients and 50 healthy individuals without gastrointestinal …
Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells
Publication Year: 2025 Source: Drug Des Devel Ther PMID: 39845151
BACKGROUND: Huanglian-ejiao decoction (HED) is a Chinese traditional medicinal formula evolved from the Shanghan Lun (Treatise on Febrile Diseases). However, HED ultimate mechanism of action remained indistinct. Therefore, this study aimed to investigate whether HED could exert anti-inflammatory effects on 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through the regulation of …
Multi-omics perspective: mechanisms of gastrointestinal injury repair
Publication Year: 2025 Source: Burns Trauma PMID: 39845194
In this review, we examine the significance of multi-omics technologies in understanding the plethora of intricate processes that activate gastrointestinal (GI) injury repair. Multi-omics, which includes genomics, transcriptomics, proteomics, and metabolomics, allows intricate mapping of cellular responses and molecular pathways involved in GI repair. We highlight the potential of multi-omics …
Analysis of nanomedicine applications for inflammatory bowel disease: structural and temporal dynamics, research hotspots, and emerging trends
Publication Year: 2025 Source: Front Pharmacol PMID: 39845796 DOI: 10.3389/fphar.2024.1523052
BACKGROUND: The application of nanomedicine in inflammatory bowel disease (IBD) has gained significant attention in the recent years. As the field rapidly evolves, analyzing research trends and identifying research hotpots are essential for guiding future advancements, and a comprehensive bibliometric can provide valuable insights. METHODS: The current research focused on …
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