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Durability of Antibody Responses to SARS-CoV-2 Vaccination over 12 Months in Pediatric Inflammatory Bowel Disease
Publication Year: 2025 Source: Vaccines (Basel) PMID: 40573880
BACKGROUND/OBJECTIVES: Severe acute respiratory syndrome (SARS-CoV-2) has had a profound global impact and continues to represent a health challenge worldwide. The durability of SARS-CoV-2 vaccine responses in pediatric inflammatory bowel disease (PIBD) patients receiving biologic therapies is unknown. This study aimed to quantify SARS-CoV-2 antibody responses post vaccination in these …
SARS-CoV-2 Variant-Specific Antibodies in Vaccinated Inflammatory Bowel Disease Patients
Publication Year: 2025 Source: Vaccines (Basel) PMID: 40573926 DOI: 10.3390/vaccines13060595
Background/Objectives: Patients suffering from inflammatory bowel diseases (IBDs) undergoing treatment with anti-TNF antibodies mount a diminished humoral immune response to vaccination against SARS-CoV-2 compared to healthy controls. The characterization of variant-specific immune responses is particularly warranted among immunosuppressed patients, where reduced responses may necessitate further medical interventions. Methods: This pilot …
Highly multiplexed molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole-genome sequencing assessments for selection and relatedness
Publication Year: 2025 Source: Front Genet PMID: 40574802 DOI: 10.3389/fgene.2025.1526049
INTRODUCTION: The use of next-generation sequencing technologies (NGS) to study parasite populations and their response and evolution to interventions is important to support malaria control and elimination efforts. While whole-genome sequencing (WGS) is optimal in terms of assessing the entire genome, it is costly for numerous samples. Targeted approaches selectively …
Correction: Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity
Publication Year: 2025 Source: Front Immunol PMID: 40574838
[This corrects the article DOI: 10.3389/fimmu.2025.1568062.].
Refractory Crohn's disease complicated with Guillain-Barré syndrome: A case report
Publication Year: 2025 Source: World J Clin Cases PMID: 40574926 DOI: 10.12998/wjcc.v13.i18.103618
BACKGROUND: Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory gastrointestinal disorders, including Crohn's disease (CD) and ulcerative colitis, with uncertain etiologies. The natural course of IBD can be accompanied by extraintestinal manifestations involving the skin, mucous membranes, musculoskeletal structures, eyes, cardiovascular system and nervous system. Guillain-Barre syndrome (GBS) …
The role of exome data reanalysis in clarifying STXBP3 associated inflammatory bowel disease and hearing loss
Publication Year: 2025 Source: Gastroenterol Rep (Oxf) PMID: 40575033
No Abstract
Application of Wuling powder in the treatment of ulcerative colitis complicated by depression as a new therapy principle
Publication Year: 2025 Source: World J Gastroenterol PMID: 40575332
The problem of ulcerative colitis (UC) is becoming increasingly relevant due to its prevalence and combination with psychological disorders. UC is associated with alterations in the intestinal microbiocenosis as one of the factors reducing tolerance to self-antigens. In addition, patients with UC often experience anxiety, depression and other negative emotional …
Four-strain probiotic exerts a positive effect on irritable bowel syndrome symptoms occurring in inflammatory bowel diseases in absence of inflammation (train-IBD trial)
Publication Year: 2025 Source: World J Gastrointest Pharmacol Ther PMID: 40575360 DOI: 10.4292/wjgpt.v16.i2.101268
BACKGROUND: Irritable bowel syndrome (IBS) symptoms are common in patients with inflammatory bowel disease (IBD), with systematic review reporting an overall pooled prevalence of 35-39% in patients with clinical remission. This subset of patients reports a reduced quality of life and increased anxiety and depression. A multi-strain probiotic (Symprove, Symprove …
Comorbidities and systemic steroids drive pneumonia risk in inflammatory bowel disease: Propensity score-matched cohort study
Publication Year: 2025 Source: World J Gastrointest Pharmacol Ther PMID: 40575363 DOI: 10.4292/wjgpt.v16.i2.105335
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at an increased risk of bacterial pneumonia, contributing to significant morbidity and mortality. While previous studies have identified various risk factors, including medications and comorbidities, the independent contribution of IBD to pneumonia risk remains unclear. We hypothesized that the increased pneumonia risk …
The Spectrum of Psychiatric Comorbidity in Individuals With Inflammatory Bowel Disease
Publication Year: 2025 Source: Crohns Colitis 360 PMID: 40575615 DOI: 10.1093/crocol/otaf035
BACKGROUND: Research on psychiatric comorbidity in inflammatory bowel disease (IBD) has focused mostly on anxiety and depression. This study aimed to describe the spectrum of psychiatric disorders experienced by individuals with IBD and their overlap. METHODS: Participants were enrolled in a prospective 3-year longitudinal study that assessed psychiatric comorbidity in …
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