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The hidden burden: Inflammatory bowel disease and cardiovascular mortality in underreported populations
Publication Year: 2025 Source: Int J Cardiol Cardiovasc Risk Prev PMID: 40575717 DOI: 10.1016/j.ijcrp.2025.200449
Recent data from the United States reveal a rising trend in mortality linked to inflammatory bowel disease (IBD) and cardiovascular disease (CVD), with pronounced disparities across age, sex, race, and geography. This commentary reappropriates those findings within the context of the Philippines and other low- and middle-income countries (LMICs), where …
Kirurgi ved Crohns sykdom
Publication Year: 2025 Source: Tidsskr Nor Laegeforen PMID: 40575820
BACKGROUND: For patients with Crohn's disease, surgery can be appropriate when medical treatment fails to adequately control the condition, or in cases of stenosis, fistulas or abscesses. We aimed to investigate the types of bowel surgery these patients undergo, as well as waiting times and the prevalence of serious complications. …
Assessing inflammatory bowel disease monitoring procedures in Spain: insights from the IBD-PODCAST study
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40575892 DOI: 10.17235/reed.2025.11190/2025
INTRODUCTION: Crohn's disease (CD) and ulcerative colitis (UC) are characterized by persistent gastrointestinal inflammation. Timely, effective management is crucial for improving long-term patient outcomes. MATERIALS AND METHODS: As part of the IBD-PODCAST study, this cross-sectional, multicenter, non-interventional study included 396 patients (196 CD, 200 UC) from 14 Spanish hospitals, aiming …
The sleep quality and its association with disease activity in patients with inflammatory bowel disease: a meta-analysis
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40575902 DOI: 10.17235/reed.2025.11305/2025
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is linked to poor sleep quality, though evidence remains inconsistent. This meta-analysis aimed to evaluate sleep quality in IBD patients and its association with disease activity. METHODS: We systematically searched databases up to February 2025 for studies …
Sudden onset of severe oral and gastrointestinal lesions in a patient with lung cancer
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40575907
Severe oral and gastrointestinal mucositis, though rare with immune checkpoint inhibitors, represents a life-threatening immune-related adverse events (irAE) requiring prompt recognition1,2. Key diagnostic steps include ruling out infections and inflammatory bowel disease. Early high-dose corticosteroids are the cornerstone of therapy, with escalation to biologic agents in refractory cases.
Digestive disease in individuals living with obesity: beyond weight loss
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40575928
Obesity is a chronic, progressive, and systemic disease that profoundly reshapes the landscape of digestive health. Beyond excess adiposity, it constitutes a multifactorial condition driven by complex interactions among genetic, metabolic, microbiological, and social determinants. This narrative review delineates the extensive and heterogeneous impact of obesity across the digestive tract, …
Colo-colonic intussusception as an atypical initial presentation of inflammatory bowel disease
Publication Year: 2025 Source: Rev Esp Enferm Dig PMID: 40575933 DOI: 10.17235/reed.2025.11329/2025
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Association Between ADHD and Pediatric Asthma: Results From a Large-Sample Cross-Sectional Study of National Surveys and Mendelian Randomization Analyses
Publication Year: 2025 Source: J Atten Disord PMID: 40576263
BACKGROUND: ADHD often overlaps with pediatric asthma, leading to difficulties in treatment and management in clinical work. Previous research has explored their correlations but gained different conclusions. Thus, this work aims to fill this evidence gap. METHODS: Initially, we conducted a cross-sectional study based on data from the National Health …
Deciphering the Interference of the Anti-Integrin α4β7 Vedolizumab With Cell Crossmatch
Publication Year: 2025 Source: HLA PMID: 40576307 DOI: 10.1111/tan.70301
In organ transplantation, immunological risk assessment uses cell crossmatch (XM) results, which can be altered by several drugs. We observed two recipients awaiting kidney and liver transplantation with positive flow cytometry XM (FCXM) on T-cells in the absence of Donor Specific Antibodies (DSA). Both were treated with vedolizumab (VDZ) for …
Emerging nanocarrier systems for the enhanced delivery of active pharmaceutical ingredients to the intestine
Publication Year: 2025 Source: Nanomedicine (Lond) PMID: 40576347 DOI: 10.1080/17435889.2025.2520157
This review explores the recent advancements in nanodelivery systems designed to improve intestinal delivery, focusing on inflammatory bowel diseases (IBDs) and colorectal cancer (CRC). It outlines the challenges associated with conventional drug therapies, including poor bioavailability, systemic side effects, and nonspecific targeting, which often limit therapeutic outcomes. Nanotechnology-based delivery platforms, …
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