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Gaps between European Crohn's and Colitis Organisation quality standards of care and the real world on diagnosis and monitoring inflammatory bowel disease across Europe: results from the E-QUALITY survey
Publication Year: 2025 Source: J Crohns Colitis PMID: 40576379 DOI: 10.1093/ecco-jcc/jjaf105
BACKGROUND AND AIMS: Quality of care in inflammatory bowel disease (IBD) management is crucial for early detection and prevention of disease progression and complications. The European Crohn's and Colitis Organisation (ECCO) developed evidence-based recommendations and quality of care (QoC) standards for IBD management, but gaps between these standards and real-world …
Rethinking iron therapy in IBD: integrating the microbiota perspective
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 40576627 DOI: 10.1080/00365521.2025.2525909
Iron deficiency and anemia are common in patients with inflammatory bowel disease (IBD), requiring effective and well-tolerated iron replacement strategies. While oral iron is widely used, growing evidence suggests it can disrupt the gut microbiota by reducing beneficial commensal bacteria and promoting pro-inflammatory shifts in the intestinal environment. These changes …
Food for Thought: EEN as Adjunct Bridge Therapy in Adult Crohn's with Strictures
Publication Year: 2025 Source: Dig Dis Sci PMID: 40576715 DOI: 10.1007/s10620-025-09151-3
No Abstract
A Guide Through the Tunnel: Updates in the Approach to Classification and Management of Perianal Fistulizing Crohn's Disease
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 40576852
PURPOSE OF REVIEW: Perianal fistulizing Crohn's disease (PFCD) is a severe and debilitating phenotype of Crohn's disease that presents significant clinical and therapeutic challenges. This review aims to outline a practical approach to classification and management, emphasizing the utility of the TOpClass system. RECENT FINDINGS: The TOpClass classification incorporates clinical …
The epidemiological trends of inflammatory bowel disease among women of reproductive age: a global analysis from 1990 to 2021
Publication Year: 2025 Source: Immunol Res PMID: 40576854 DOI: 10.1007/s12026-025-09658-x
This study aimed to evaluate the global burden of inflammatory bowel disease (IBD) among women of reproductive age (15-49 years) from 1990 to 2021, analyze its association with socio-demographic index (SDI), and identify age-period-cohort (APC) effects to inform region-specific public health strategies. Using data from the Global Burden of Disease …
Impact of complete vs partial endoscopic healing on long-term outcomes in Crohn's disease: a prospective multicenter study
Publication Year: 2025 Source: J Crohns Colitis PMID: 40577076
INTRODUCTION: The STRIDE II guidelines recognize endoscopic healing (EH), defined by an SES-CD score </= 2, as one of the main therapeutic targets in Crohn's disease (CD). Nevertheless, complete EH could further reduce the risk of long-term complications in CD. We aimed to assess the risk of long-term complications in …
Patients With Crohn's Disease and Terminal Ileum Resection are at Increased Risk of Colorectal Cancer: A Population-Based Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40577099
Patients with Crohn's disease (CD) who undergo terminal ileum (TI) resection experience altered bile acid absorption, which may influence colorectal cancer (CRC) risk. We conducted a propensity-matched cohort study using TriNetX to compare CRC risk in patients with CD who underwent TI resection versus those who did not. Terminal ileum …
clusIBD: Robust Detection of Identity-by-descent Segments Using Unphased Genetic Data from Poor-quality Samples
Publication Year: 2025 Source: Genomics Proteomics Bioinformatics PMID: 40578321 DOI: 10.1093/gpbjnl/qzaf055
The detection of identity-by-descent (IBD) segments is widely used to infer relatedness in many fields, including forensics and ancient DNA analysis. However, existing methods are often ineffective for poor-quality DNA samples. Here, we propose a method, clusIBD, which can robustly detect IBD segments using unphased genetic data with a high …
Exploring the Role of Wearable Devices in Inflammatory Bowel Disease Management
Publication Year: 2025 Source: Gastroenterology PMID: 40578574
No Abstract
Dysregulated Pro-inflammatory and Anti-inflammatory Cytokine Responses to Microbe-associated Molecular Patterns in X-linked Chronic Granulomatous Disease
Publication Year: 2025 Source: In Vivo PMID: 40578979 DOI: 10.21873/invivo.13989
BACKGROUND/AIM: Chronic granulomatous disease (CGD) is a hereditary immune deficiency caused by mutations in nicotinamide adenine dinucleotide phosphate oxidase subunits. X-linked CGD caused by mutations in gp91(phox) is characterized by recurrent bacterial and fungal infections and by an increased incidence of autoimmunity and inflammatory bowel disease (IBD). The concurrent occurrence …
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