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Clonal Hematopoiesis of Indeterminate Potential in Crohn's Disease and Ulcerative Colitis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39761417 DOI: 10.1093/ibd/izae312
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is the presence of somatic mutations in myeloid and lymphoid malignancy genes in the blood cells of individuals without a hematologic malignancy. Inflammation is hypothesized to be a key mediator in the progression of CHIP to hematologic malignancy and patients with CHIP have …
A galacturonic acid-rich polysaccharide from Citrus medica 'fingered' alleviated the dextran sulfate sodium-induced ulcerative colitis
Publication Year: 2025 Source: Int J Biol Macromol PMID: 39761893
Ulcerative colitis (UC) treatment is often limited by adverse reactions and high recurrence rates, highlighting the need for safer, more effective therapies. Citrus medica 'Fingered' (C. medica), known for its anti-inflammatory properties, remains underexplored, particularly its polysaccharide components. This study investigated the intestinal protective effects of C. medica polysaccharides extracted …
FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial
Publication Year: 2025 Source: BMJ Open PMID: 39762111 DOI: 10.1136/bmjopen-2024-095392
INTRODUCTION: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven several pathogenic hypotheses to which the intestinal microbiome is proposed to contribute. Pilot studies of faecal microbiota transplantation (FMT) in PSC and IBD are demonstrated …
Association of real life postural transitions kinematics with fatigue in neurodegenerative and immune diseases
Publication Year: 2025 Source: NPJ Digit Med PMID: 39762451
Fatigue is prevalent in immune-mediated inflammatory and neurodegenerative diseases, yet its assessment relies largely on patient-reported outcomes, which capture perception but not fluctuations over time. Wearable sensors, like inertial measurement units (IMUs), offer a way to monitor daily activities and evaluate functional capacity. This study investigates the relationship between sit-to-stand …
Age-standardized incidence, prevalence, mortality rates and future projections of autoimmune diseases in China: a systematic analysis based on GBD 2021
Publication Year: 2025 Source: Immunol Res PMID: 39762576 DOI: 10.1007/s12026-024-09591-5
This study assessed trends in age-standardized incidence (ASIR), prevalence (ASPR), and mortality rates (ASMR) per 100,000 population for asthma, Type 1 Diabetes Mellitus (T1DM), Inflammatory Bowel Disease (IBD), Multiple Sclerosis (MS), Psoriasis, and Rheumatoid Arthritis (RA) in China from 1990 to 2021 and projected ASIR trends through 2046. Data were …
Outcomes of Hematopoietic Stem Cell Transplantation in 5 Patients with Autosomal Recessive RIPK1-Deficiency
Publication Year: 2025 Source: J Clin Immunol PMID: 39762600
Receptor Interacting Serine/Threonine Kinase 1 (RIPK1) is widely expressed and integral to inflammatory and cell death responses. Autosomal recessive RIPK1-deficiency, due to biallelic loss of function mutations in RIPK1, is a rare inborn error of immunity (IEI) resulting in uncontrolled necroptosis, apoptosis and inflammation. Although hematopoietic stem cell transplantation (HSCT) …
Usefulness of Magnifying Endoscopy With Narrow-Band Imaging for Diagnosis of Ulcerative Colitis-Associated Neoplasia
Publication Year: 2025 Source: J Gastroenterol Hepatol PMID: 39763012
BACKGROUND AND AIM: Qualitative diagnosis of ulcerative colitis-associated neoplasia (UCAN) is crucial for surveillance colonoscopy in patients with ulcerative colitis (UC). Although the utility of magnifying endoscopy with narrow-band imaging (ME-NBI) in sporadic neoplasia diagnosis has been reported, its efficacy in UCAN remains unclear. This study aimed to evaluate the …
L-Arginine-Modified Selenium Nanozymes Targeting M1 Macrophages for Oral Treatment of Ulcerative Colitis
Publication Year: 2025 Source: Small PMID: 39763139
Ulcerative colitis (UC) involves persistent inflammation in the colon and rectum, with excessive reactive oxygen species (ROS) accumulation. This ROS buildup damages colonic epithelial cells and disrupts intestinal flora, worsening disease progression. Current antioxidant therapies are limited due to their instability in the gut and lack of targeting, hindering precise …
Autoimmune diseases and risk of gastrointestinal cancer: an umbrella review of meta-analyses of observational studies
Publication Year: 2025 Source: Int J Surg PMID: 39764592 DOI: 10.1097/JS9.0000000000002219
BACKGROUND: Several autoimmune diseases (ADs) are considered risk factors for gastrointestinal (GI) cancers. This study pooled and appraised the evidence associating ADs with GI cancer risks. METHODS: Three databases were examined from initiation through 26 January 2024. Evidence was determined by the criteria including the P -value of random-effects, small-study …
Genomic Prediction of Individual Inbreeding Levels for the Management of Genetic Diversity in Populations With Small Effective Size
Publication Year: 2025 Source: Mol Ecol Resour PMID: 39764642 DOI: 10.1111/1755-0998.14068
In populations of small effective size (N(e)), such as those in conservation programmes, companion animals or livestock species, inbreeding control is essential. Homozygosity-by-descent (HBD) segments provide relevant information in that context, as they allow accurate estimation of the inbreeding coefficient, provide locus-specific information and their length is informative about the …
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