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Preoperative Nutrition Status Predicts Hospital Length of Stay and Unplanned Reoperation Risk in Pediatric Patients With Inflammatory Bowel Disease
Publication Year: 2025 Source: J Pediatr Surg PMID: 39765027 DOI: 10.1016/j.jpedsurg.2024.162147
INTRODUCTION: Many pediatric inflammatory bowel disease (IBD) patients require surgical intervention during their lifetime. Poor nutrition status correlates with adverse surgical outcomes in the adult population. A paucity of data exists on the association of preoperative nutrition status and postoperative outcomes in the pediatric population. We sought to determine the …
Engineered Therapeutic Bacteria with High-Yield Membrane Vesicle Production Inspired by Eukaryotic Membrane Curvature for Treating Inflammatory Bowel Disease
Publication Year: 2025 Source: ACS Nano PMID: 39772458 DOI: 10.1021/acsnano.4c13069
Bacterial membrane vesicles (BMVs) are emerging as powerful natural nanoparticles with transformative potential in medicine and industry. Despite their promise, scaling up BMV production and ensuring stable isolation and storage remain formidable challenges that limit their broader application. Inspired by eukaryotic mechanisms of membrane curvature, we engineered Escherichia coli DH5alpha …
The TL1A inhibitors in IBD: what's in the pot?
Publication Year: 2025 Source: Expert Rev Gastroenterol Hepatol PMID: 39772947 DOI: 10.1080/17474124.2025.2450795
INTRODUCTION: Inflammatory bowel diseases (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), present ongoing challenges despite advances in pathophysiological understanding and therapeutic options. Current therapies often fail to achieve sustained remission, necessitating exploration of novel treatment targets. AREAS COVERED: This review explores the role of Tumor Necrosis Factor-like cytokine …
Efficacy of umbilical cord-derived mesenchymal stem cells and exosomes in conjunction with standard IBD drug on immune responses in an IBD mouse model
Publication Year: 2025 Source: Stem Cell Res Ther PMID: 39773498 DOI: 10.1186/s13287-024-04062-y
BACKGROUND: Inflammatory bowel disease (IBD) is a persistent inflammation of the digestive system, and Mesenchymal Stem Cells (MSCs) and their exosomes have demonstrated potential as treatments for this condition. The objective of this research was to examine the possible effectiveness of intraperitoneal injection of umbilical cord-MSCs (UC-MSCs) and their exosomes …
Impact of Prior Biologic Exposure on Ozanimod Efficacy and Safety in the Phase 3 True North Clinical Trial
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39773524
INTRODUCTION: Patients with ulcerative colitis (UC) and prior biologic failure may have reduced or delayed efficacy with subsequent advanced therapies. This analysis evaluated the efficacy and safety of ozanimod during the True North (TN) study and its open-label extension (OLE) in biologic-exposed patients with UC. METHODS: TN was a randomized, …
The Effect of Low-Dose Aspirin on Disease Activity in Pregnant Individuals With Inflammatory Bowel Disease
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39773571 DOI: 10.14309/ajg.0000000000003304
INTRODUCTION: Low-dose aspirin (LDA) is recommended for pregnant individuals at elevated risk for hypertensive disorders of pregnancy (HDP). However, regular aspirin use may raise concerns of increased disease activity in patients with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence of LDA use in pregnant IBD patients and …
Paucity of viral infection symptoms in patients with immune-mediated inflammatory diseases
Publication Year: 2025 Source: BMJ Open PMID: 39773803
OBJECTIVES: Although patients with immune-mediated inflammatory diseases (IMID) are thought to be more susceptible to viral infections, it is unclear whether their presentation differs between patients with IMID and healthy controls. This study aimed to investigate the symptom pattern of common viral infections in patients with IMID and compare it …
Colonic tuberculosis mimicking malignancy: a multidisciplinary medical and surgical approach
Publication Year: 2025 Source: BMJ Case Rep PMID: 39773971
Colonic tuberculosis (TB) is a rare form of extrapulmonary TB with nonspecific clinical presentations such as weight loss, abdominal pain and fever. It is often misdiagnosed, as the presentations mimic other more common diseases such as colon cancer and inflammatory bowel diseases, especially in those countries with low TB incidence. …
Ubiquitin-specific protease 25 ameliorates ulcerative colitis by regulating the degradation of phosphor-STAT3
Publication Year: 2025 Source: Cell Death Dis PMID: 39773987
Ubiquitin-specific protease 25 (USP25), a member of the deubiquitination family, plays an important role in protein ubiquitination, degradation, inflammation, and immune regulation. However, the role and mechanism of USP25 in ulcerative colitis (UC) remain unclear. To study the role and mechanism of USP25 in UC, bioinformatics analysis and research are …
Metabolic Disorders and Inflammatory Bowel Diseases
Publication Year: 2025 Source: Gut Liver PMID: 39774122 DOI: 10.5009/gnl240316
Inflammatory bowel disease (IBD) is characterized by chronic immune-mediated intestinal inflammation, presenting with a spectrum of metabolic disorders as well as intestinal and extraintestinal manifestations. Lifestyle factors, genetic predisposition, immune dysfunction, and gut bacteria composition contribute to the development of IBD. Several comorbidities, including cardiovascular diseases, thrombosis, and metabolic disorders, …
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