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Paradoxical Inflammatory Bowel Disease Induced by Golimumab in a Patient With Ankylosing Spondylitis: A Case Report and Systematic Review
Publication Year: 2025 Source: Cureus PMID: 39807347 DOI: 10.7759/cureus.77363
Paradoxical reactions (PRs) to biologic medications, such as psoriasis, arthritis, and inflammatory bowel disease (IBD), have been increasingly recognized. The aim of reporting this case is to establish an association between golimumab and exacerbation or new (de novo) IBD in patients with axial spondyloarthritis (SpA). Our case involves a young …
A review on the effects of flavan-3-ols, their metabolites, and their dietary sources on gut barrier integrity
Publication Year: 2025 Source: Food Funct PMID: 39807528
Impairment of gut barrier integrity is associated with the pathogenesis of gastrointestinal diseases, including inflammatory bowel disease, colorectal cancer, and coeliac disease. While many aspects of diet have been linked to improved barrier function, (poly)phenols, a broad group of bioactive phytochemicals, are of potential interest. The (poly)phenolic sub-class, flavan-3-ols, have …
Impact of Disease Etiology and Indication for Colectomy on Postoperative Outcomes: NSQIP Colectomy-Targeted Database Study
Publication Year: 2025 Source: J Am Coll Surg PMID: 39807794 DOI: 10.1097/XCS.0000000000001280
BACKGROUND: The American College of Surgeons (ACS) NSQIP Colectomy-Targeted database provides valuable metrics on surgical outcomes by using clinical data to enhance quality improvement efforts. However, the quality measures offered in the ACS NSQIP semiannual report do not stratify for the indication of colectomy. We aim to compare postoperative outcomes …
The fate of the rectum in ulcerative colitis at index surgery and beyond-a contemporary cohort
Publication Year: 2025 Source: Int J Colorectal Dis PMID: 39808215
PURPOSE: Proctectomy is frequently deferred at index colectomy for ulcerative colitis due to acuity or immunosuppressive treatments. The retained rectum remains symptomatic in over 50% with associated cancer risk. Management options include index or delayed proctectomy with or without restoration of continuity or surveillance. Comparative studies of perioperative outcomes and …
Associated diseases and their effects on disease course in patients with chronic non-bacterial osteomyelitis: retrospective experience from a single center
Publication Year: 2025 Source: Clin Rheumatol PMID: 39808231 DOI: 10.1007/s10067-025-07306-1
OBJECTIVE: Chronic non-bacterial osteomyelitis (CNO) is a rare autoinflammatory bone disease associated with other chronic inflammatory diseases such as familial Mediterranean fever (FMF), juvenile idiopathic arthritis (JIA), spondylarthropathies, inflammatory bowel disease (IBD), and pyoderma gangrenosum. We aimed to describe the clinical and follow-up characteristics of patients with CNO and to …
Protective role of ABCC drug subfamily resistance transporters (ABCC1-7) in intestinal inflammation
Publication Year: 2025 Source: Immunol Res PMID: 39808251 DOI: 10.1007/s12026-024-09583-5
The ABCC subfamily contains thirteen members. Nine of these transporters are called multidrug resistance proteins (MRPs). The MRPs have been associated with developing ulcerative colitis (UC). This study aimed to evaluate the ABCC expression in UC patients and its role in a dextran sulfate sodium (DSS)-induced colitis mice model under …
Estimating realized relatedness in free-ranging macaques by inferring identity-by-descent segments
Publication Year: 2025 Source: Proc Natl Acad Sci U S A PMID: 39808663 DOI: 10.1073/pnas.2401106122
Biological relatedness is a key consideration in studies of behavior, population structure, and trait evolution. Except for parent-offspring dyads, pedigrees capture relatedness imperfectly. The number and length of identical-by-descent DNA segments (IBD) yield the most precise relatedness estimates. Here, we leverage different methods for estimating IBD segments from low-depth whole …
Neuroprotective role of mirabegron: Targeting beta-3 adrenergic receptors to alleviate ulcerative colitis-associated cognitive impairment
Publication Year: 2025 Source: Biomed Pharmacother PMID: 39809125
While cognitive impairment has been documented in ulcerative colitic patients, the possible influence of central beta3-adrenergic receptor (beta3-AR) signaling on this extraintestinal manifestation remains unclear. Previously, we identified an imperative role for mirabegron (MA) as an agonist of beta3-AR, in decreasing the BACE-1/beta-amyloid (Abeta) cue in the colons of UC …
Ileo-ileal intussusception and necrotising enterocolitis after indomethacin exposure masquerading clinically as solitary intestinal perforation
Publication Year: 2025 Source: BMJ Case Rep PMID: 39809488
We report a case of small bowel perforation from ileo-ileal intussusception with necrotising enterocolitis (NEC) after indomethacin exposure mimicking spontaneous intestinal perforation in an extremely preterm neonate. Indomethacin exposure can cause mesenteric hypoperfusion, resulting in an ischaemic lead point for intussusception and NEC. We advocate that intussusception should be considered …
RNF128 deficiency in macrophages promotes colonic inflammation by suppressing the autophagic degradation of S100A8
Publication Year: 2025 Source: Cell Death Dis PMID: 39809743 DOI: 10.1038/s41419-025-07338-0
Macrophages play important roles in maintaining intestinal homeostasis and in the pathogenesis of inflammatory bowel diseases (IBDs). However, the underlying mechanisms that govern macrophage-mediated inflammation are still largely unknown. In this study, we report that RNF128 is downregulated in proinflammatory macrophages. RNF128 deficiency leads to elevated levels of effector cytokines …
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