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Establishment and internal validation of a model to predict the efficacy of Adalimumab in Crohn's disease
Publication Year: 2025 Source: Sci Rep PMID: 39809870
BACKGROUND: Clinically, the ability to distinguish which Crohn's disease patients can benefit from Adalimumab is limited. AIMS: This study aimed to develop a model for predicting clinical remission probability for Crohn's disease patients with Adalimumab at 12 weeks. The model assists clinicians in identifying which Crohn's disease patients are likely …
[Functional disorders in chronic inflammatory bowel disease: the gut-brain axis]
Publication Year: 2025 Source: Inn Med (Heidelb) PMID: 39809995 DOI: 10.1007/s00108-024-01832-x
BACKGROUND: In patients with inflammatory bowel diseases (IBD), functional complaints frequently persist after the clearing of inflammation and are clinically difficult to distinguish from symptoms of inflammation. In recent years, the influence of bidirectional communication between the gut and brain on gut physiology, emotions, and behavior has been demonstrated. RESEARCH …
Simultaneous Detection of Hydrogen Sulfide and Peroxynitrite Dysregulation with a Sequentially Activated Fluorescent Probe in Ulcerative Colitis Disease
Publication Year: 2025 Source: Anal Chem PMID: 39810341
No Abstract
Pseudohaematuria Due to Mesalazine: A Case Report
Publication Year: 2025 Source: Nephrology (Carlton) PMID: 39810390
The symptom of macroscopic or 'visible' haematuria can cause significant patient distress, largely due to its' potential association with urinary tract malignancy, infection or glomerular disease. This lesson from practice describes the case of a 19-year-old female patient for whom the cause of red/brown urinary discolouration was found to relate …
Exploring gut microbiota as a novel therapeutic target in Crohn's disease: Insights and emerging strategies
Publication Year: 2025 Source: World J Gastroenterol PMID: 39811502
Extensive research has investigated the etiology of Crohn's disease (CD), encompassing genetic predisposition, lifestyle factors, and environmental triggers. Recently, the gut microbiome, recognized as the human body's second-largest gene pool, has garnered significant attention for its crucial role in the pathogenesis of CD. This paper investigates the mechanisms underlying CD, …
Vedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study
Publication Year: 2025 Source: World J Gastroenterol PMID: 39811508
BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory condition requiring continuous treatment and monitoring. There is limited pharmacokinetic data on vedolizumab during maintenance therapy and the effect of thiopurines on vedolizumab trough concentrations is unknown. AIM: To investigate the exposure-response relationship of vedolizumab and the impact of thiopurine withdrawal in …
Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis
Publication Year: 2025 Source: World J Gastroenterol PMID: 39811511
The term "gut microbiota" primarily refers to the ecological community of various microorganisms in the gut, which constitutes the largest microbial community in the human body. Although adequate bowel preparation can improve the results of colonoscopy, it may interfere with the gut microbiota. Bowel preparation for colonoscopy can lead to …
Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 39811513
Inflammatory bowel disease, particularly Crohn's disease (CD), has been linked to modifications in mesenteric adipose tissue (MAT) and the phenomenon known as "creeping fat" (CrF). The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with CD. Notably, the incorporation …
Therapeutic Potential of Vanillic Acid in Ulcerative Colitis Through Microbiota and Macrophage Modulation
Publication Year: 2025 Source: Mol Nutr Food Res PMID: 39812000
This study investigated the protective effects of the dietary polyphenol vanillic acid (VA) on dextran sulfate sodium-induced acute ulcerative colitis (UC) in mice, focusing on its impact on the gut microbiota and inflammatory responses. VA was supplemented following dextran sulfate sodium administration, and key indicators, including body weight, disease activity …
Tunisian recommendations of good practice for the therapeutic management of spondyloarthritis (excluding biological treatment)
Publication Year: 2025 Source: Tunis Med PMID: 39812192 DOI: 10.62438/tunismed.v103i1.5565
AIM: To develop good practice recommendations (GPR) for the therapeutic management of patients with spondyloarthritis (SpA), including psoriatic arthritis. METHODS: Following standardised procedures, a systematic review of the literature was carried out on non-pharmacological and non-biological pharmacological treatments for SpA. The review was based on questions defined by a working …
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