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Host-microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease
Publication Year: 2025 Source: Gut Microbes PMID: 39812341 DOI: 10.1080/19490976.2025.2450207
Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing inflammatory bowel disorders (IBD), the pathogenesis of which is uncertain but includes genetic susceptibility factors, immune-mediated tissue injury and environmental influences, most of which appear to act via the gut microbiome. We hypothesized that host-microbe alterations could be used to …
Failure of colonization following gut microbiota transfer exacerbates DSS-induced colitis
Publication Year: 2025 Source: Gut Microbes PMID: 39812347 DOI: 10.1080/19490976.2024.2447815
To study the impact of differing specific pathogen-free gut microbiomes (GMs) on a murine model of inflammatory bowel disease, selected GMs were transferred using embryo transfer (ET), cross-fostering (CF), and co-housing (CH). Prior work showed that the GM transfer method and the microbial composition of donor and recipient GMs can …
Baseline Drug Clearance Predicts Outcomes in Children With Inflammatory Bowel Disease Treated With Vedolizumab: Results From the VedoKids Prospective Multicentre Study
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39812549 DOI: 10.1111/apt.18484
BACKGROUND: The pharmacokinetics of biologic agents can differ between children and adults with inflammatory bowel disease (IBD), often necessitating modified paediatric dosing strategies. AIMS: To define the exposure-response relationship of vedolizumab in the paediatric IBD VedoKids cohort including the effect of baseline clearance on deep biochemical remission (normal C-reactive protein …
Refining the clinical and therapeutic spectrum of granulomatous myositis from a large cohort of patients
Publication Year: 2025 Source: J Neurol PMID: 39812689
OBJECTIVES: Granulomatous myositis (GM) is a rare entity whose precise clinical features and therapeutic outcomes have not yet been well defined. Given the limited evidence, data from a large cohort of patients is needed to aid in the recognition and management of this condition. METHODS: We retrospectively analyzed our institutional …
Disease-State Dependent Associations Between Intrinsic Brain Function and Symptoms of Fatigue, Depression, and Anxiety in Crohn's Disease
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39813157
BACKGROUND: Extraintestinal symptoms (EIS) in inflammatory bowel diseases, including fatigue, depression and anxiety, are highly prevalent, but poorly understood. Alterations of brain function may contribute to EIS, but their association with disease activity is unclear. This study analyzed intrinsic neural activity (INA) of individuals with Crohn's disease (CD) in different …
Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach
Publication Year: 2025 Source: PLoS One PMID: 39813219 DOI: 10.1371/journal.pone.0316584
BACKGROUND: Rheumatoid arthritis (RA) is a degenerative autoimmune disease, often managed through symptomatic treatment. The co-occurrence of the reported extra-articular comorbidities such as inflammatory bowel disease (IBD), and dementia may complicate the pathology of the disease as well as the treatment strategies. Therefore, in our study, we aim to elucidate …
Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease
Publication Year: 2025 Source: Sci Transl Med PMID: 39813315 DOI: 10.1126/scitranslmed.adn8699
Dysregulation at the intestinal epithelial barrier is a driver of inflammatory bowel disease (IBD). However, the molecular mechanisms of barrier failure are not well understood. Here, we demonstrate dysregulated mitochondrial fusion in intestinal epithelial cells (IECs) of patients with IBD and show that impaired fusion is sufficient to drive chronic …
Oral administration of Folium Artemisiae Argyi-derived exosome-like nanovesicles can improve ulcerative colitis by regulating intestinal microorganisms
Publication Year: 2025 Source: Phytomedicine PMID: 39813847
BACKGROUND: Ulcerative colitis (UC), an inflammatory disease characterized by intestinal barrier dysfunction, poses significant challenges because of the toxicity and adverse effects commonly associated with conventional therapies. Safer and more efficacious treatment strategies are needed. PURPOSE: The purpose of this study was to treat UC with Folium Artemisiae Argyi exosome-like …
Pediatric Hidradenitis Suppurativa: An Overview
Publication Year: 2025 Source: Skin Therapy Lett PMID: 39814056
Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory skin disease that significantly impacts the quality of life of patients.[1] HS is more common in adults and adolescents, although true incidence rates may be underestimated due to a lack of earlier recognition of HS in children.[2] Pediatric HS is a challenging …
Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort
Publication Year: 2025 Source: Gastroenterology PMID: 39814239
BACKGROUND & AIMS: To decipher the mechanisms underlying the protective role of the Mediterranean diet (MED) in Crohn's disease (CD), we explored the implications of adherence to MED on CD course, inflammatory markers, and microbial and metabolite composition. METHODS: Patients with newly diagnosed CD were recruited and followed prospectively. MED …
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