Research Articles Library
Literature Analysis Tools
Advanced Search
Filter by PMID, year, source, DOI and other criteria
Literature Analysis
Analyze research trends and hotspots
Batch Export
Export search results to Excel/PDF
Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects
Publication Year: 2025 Source: Trends Mol Med PMID: 39814640 DOI: 10.1016/j.molmed.2024.12.005
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder that represents a significant public health challenge worldwide. This multifactorial condition results from complex interactions among genetic, environmental, immune, and microbial factors. Some beneficial microbes, known as probiotics, have been identified as promising therapeutic agents for inflammatory conditions, such as IBD. …
Biological characteristics, immune infiltration and drug prediction of PANoptosis related genes and possible regulatory mechanisms in inflammatory bowel disease
Publication Year: 2025 Source: Sci Rep PMID: 39814753 DOI: 10.1038/s41598-024-84911-1
PANoptosis is one of several modes of programmed cell death (PCD) and plays an important role in many inflammatory and immune diseases. The role of PANoptosis in inflammatory bowel disease (IBD) is currently unknown. Differentially expressed PANoptosis-related genes (DE-PRGs) were identified, and pathway enrichment analyses were performed. LASSO regression model …
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
Publication Year: 2025 Source: Nature PMID: 39814891
Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)-LTbeta receptor (LTbetaR) pathway(1), the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), …
Clinical and radiological features of gastric and small intestinal anisakiasis: comparison with gastric ulcers and crohn's disease
Publication Year: 2025 Source: Jpn J Radiol PMID: 39815123
PURPOSE: To compare the clinical and radiological features of gastric and small intestinal anisakiasis with those of gastric ulcers and Crohn's disease. MATERIALS AND METHODS: In this retrospective cohort study, 205 cases of anisakiasis (148 gastric; 53 small intestinal) were identified between July 2003 and February 2022. The control groups …
Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn's disease
Publication Year: 2025 Source: Gut Microbes PMID: 39815413
IgA-coated fractions of the intestinal microbiota of Crohn's disease (CD) patients have been shown to contain taxa that hallmark the compositional dysbiosis in CD microbiomes. However, the correlation between other cellular properties of intestinal bacteria and disease has not been explored further, especially for features that are not directly driven …
Inflammation Targeting-Triggered Healing Hydrogel for In Situ Reconstruction of Colonic Mucosa
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39815450 DOI: 10.1002/advs.202411010
Inflammatory bowel disease (IBD) is characterized by intestinal mucosal damage that exacerbates inflammation and promotes disease recurrence. Although hydrogel-based therapies have shown potential for mucosal repair, challenges remain due to inadequate targeting and low hydrogel density, leading to ongoing infiltration of harmful substances and delayed mucosal healing. In this study, …
Helminth extracellular vesicles co-opt host monocytes to drive T cell anergy
Publication Year: 2025 Source: J Extracell Vesicles PMID: 39815783
Parasitic helminths secrete extracellular vesicles (EVs) into their host tissues to modulate immune responses, but the underlying mechanisms are poorly understood. We demonstrate that Ascaris EVs are efficiently internalised by monocytes in human peripheral blood mononuclear cells and increase the percentage of classical monocytes. Furthermore, EV treatment of monocytes induced …
Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation
Publication Year: 2025 Source: Immunometabolism (Cobham) PMID: 39816134
The nucleotide-binding domain, leucine-rich repeat, and pyrin domain containing-protein 3 (NLRP3) inflammasome is a multiprotein complex that plays a critical role in the innate immune response to both infections and sterile stressors. Dysregulated NLRP3 activation has been implicated in a variety of autoimmune and inflammatory diseases, including cryopyrin-associated periodic fever …
Characteristics of gut microbiota dysbiosis in patients with colorectal polyps
Publication Year: 2025 Source: World J Gastrointest Oncol PMID: 39817124
This editorial, inspired by a recent study published in the World Journal of Gastrointestinal Oncology, covers the research findings on microbiota changes in various diseases. In recurrent colorectal polyps, the abundances of Klebsiella, Parvimonas, and Clostridium increase, while those of Bifidobacterium and Lactobacillus decrease. This dysbiosis may promote the formation …
Inflammatory Potential of the Diet and Risk of Crohn's Disease and Ulcerative Colitis
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39817326 DOI: 10.1111/apt.18497
BACKGROUND: Association between dietary factors and the risk of developing inflammatory bowel disease (IBD) has been studied extensively. However, identification of deleterious dietary patterns merits further study. AIM: To investigate the risk of developing Crohn's disease (CD) and ulcerative colitis (UC) according to the inflammatory score of the diet (ISD) …
Need more literature?
The current database contains 98453 research articles. If you need to search for more literature or perform AI analysis, please use our knowledge acquisition module or explore external literature resources.
External Resources: Access comprehensive literature databases worldwide