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Oral Akkermansia muciniphila Biomimetic Nanotherapeutics for Ulcerative Colitis Targeted Treatment by Repairing Intestinal Epithelial Barrier and Restoring Redox Homeostasis
Publication Year: 2025 Source: ACS Appl Mater Interfaces PMID: 39817352
The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that drive the occurrence and development of ulcerative colitis (UC). Synchronously restoring the intestinal barrier and mitigating excess RONS is a promising strategy for UC management, but its treatment outcomes are still hindered …
Meta-Analysis: Exclusive Enteral Nutrition in Adults With Ulcerative Colitis
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39817370
BACKGROUND: Exclusive enteral nutrition (EEN) is an established dietary therapy for Crohn's disease but its role in ulcerative colitis remains unclear. AIMS: To investigate the efficacy of EEN in adults with active ulcerative colitis and compare variations in treatment protocols, safety, tolerability and adherence. METHODS: We conducted a systematic search …
Factors affecting 1-year persistence with vedolizumab for ulcerative colitis: a multicenter, retrospective real-world study
Publication Year: 2025 Source: Intest Res PMID: 39818201 DOI: 10.5217/ir.2024.00063
BACKGROUND/AIMS: The objectives of this real-world study were to determine 1-year persistence with vedolizumab in patients with ulcerative colitis and to evaluate factors contributing to loss of response. METHODS: In this multicenter, retrospective, observational chart review, patients with moderately to severely active ulcerative colitis who received >/= 1 dose of …
Immune dysregulation in bipolar disorder
Publication Year: 2025 Source: J Affect Disord PMID: 39818340 DOI: 10.1016/j.jad.2025.01.062
BACKGROUND: Bipolar disorder is a debilitating mood disorder associated with a high risk of suicide and characterized by immune dysregulation. In this study, we used a multi-faceted approach to better distinguish the pattern of dysregulation of immune profiles in individuals with BD. METHODS: We analyzed peripheral blood mononuclear cells (bipolar …
Unusual Phospholipids from Morganella morganii Linked to Depression
Publication Year: 2025 Source: J Am Chem Soc PMID: 39818770
A multifactorial association study detected a probable causal connection between the prevalence of Morganella morganii in the gut microbiome and the incidence of major depressive disorder (MDD) in the human host. A bioassay-guided fractionation approach identified bacterially produced metabolites that induced pro-inflammatory immune responses. The metabolites are unusual phospholipids that …
Rhamnogalacturonan promotes intestinal mucosal repair through increased cell migration
Publication Year: 2025 Source: Am J Physiol Gastrointest Liver Physiol PMID: 39819015 DOI: 10.1152/ajpgi.00170.2024
Mucosal healing is the primary goal for inflammatory bowel disease (IBD) treatment. We previously showed the direct beneficial effects of rhamnogalacturonan (RGal) on intestinal epithelial barrier function. Here, we aimed to evaluate the effect of RGal in intestinal epithelial wound healing. Confluent cancer cell lines and colonoid monolayers were wounded, …
Unveiling the impact of perceived stigma on psychological well-being in adult patients with inflammatory bowel disease: The mediating role of patient engagement
Publication Year: 2025 Source: J Health Psychol PMID: 39819142 DOI: 10.1177/13591053241311526
This study elucidated the impact of perceived stigma on the well-being of inflammatory bowel disease (IBD) patients and explored the mediating role of patient engagement. A descriptive cross-sectional study was conducted using an online survey, recruiting participants through the Italian IBD patient organization. The survey assessed perceived stigma, psychological well-being, …
Health-related quality of life at diagnosis and follow-up in Faroese and Danish patients with inflammatory bowel disease - a Faroese IBD cohort study
Publication Year: 2025 Source: Scand J Gastroenterol PMID: 39819397 DOI: 10.1080/00365521.2025.2453429
BACKGROUND AND AIMS: Patients with inflammatory bowel disease (IBD) have lower health-related quality of life (HRQoL) than the general population. The highest incidence and prevalence rates of IBD in the world are found in the Faroe Islands, however, the HRQoL of Faroese patients is unknown. This study aimed to determine …
Exploring the Therapeutic Potential of Natural Flavonoids in Inflammatory Bowel Disease: Insights into Intestinal Mucosal Barrier Regulation
Publication Year: 2025 Source: Curr Top Med Chem PMID: 39819410 DOI: 10.2174/0115680266337430241127112031
Inflammatory Bowel Disease (IBD) is a chronic non-specific disease that affects the gastrointestinal tract, and Intestinal Mucosal Barrier (IMB) damage is closely related to its pathogenesis. The management of IBD often involves repairing the mechanical, chemical, immune, or biological barriers of the intestinal mucosa to alleviate symptoms. Currently, the treatment …
Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis
Publication Year: 2025 Source: Clin Epigenetics PMID: 39819503
BACKGROUND: IgG4-related cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are chronic fibro-inflammatory hepatobiliary conditions, with genetic, environmental, and immunologic risk factors, in which epigenetic alterations may provide insights into pathophysiology and novel biomarkers. This study is the first to assess methylation signatures in IgG4-SC. RESULTS: Whole blood DNA methylation profiling …
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