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Periodontitis and the Incidence of Inflammatory Bowel Diseases: A Nationwide Population-Based Cohort Study
Publication Year: 2025 Source: Am J Gastroenterol PMID: 39819636 DOI: 10.14309/ajg.0000000000003326
INTRODUCTION: Periodontitis and other oral health indicators are reportedly related to systemic inflammation. Our study aimed to investigate a possible association of oral health status (periodontitis and number of missing teeth) and oral hygiene behaviors (frequency of tooth brushing, dental visit, and dental scaling) with the risk of inflammatory bowel …
Specialized pro-resolving lipid mediators in gut immunophysiology: from dietary precursors to inflammation resolution
Publication Year: 2025 Source: Curr Opin Clin Nutr Metab Care PMID: 39819646 DOI: 10.1097/MCO.0000000000001103
PURPOSE OF REVIEW: This review aims to examine recent research on the role of specialized pro-resolving mediators (SPMs) in the regulation of gut immunophysiology. RECENT FINDINGS: Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, driven by disruptions in the intestinal barrier and an imbalance between …
Challenge of treatment de-escalation in inflammatory bowel diseases
Publication Year: 2025 Source: Gut PMID: 39819861 DOI: 10.1136/gutjnl-2024-334358
No Abstract
Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy - a multi-arm randomised controlled trial (HELIOS)
Publication Year: 2025 Source: Gut PMID: 39819862 DOI: 10.1136/gutjnl-2024-333446
BACKGROUND: It remains unclear if the increased colorectal neoplasia detection rate in inflammatory bowel disease (IBD) by high-definition (HD) dye-based chromoendoscopy compared with HD white-light endoscopy is due to enhanced contrast or increased inspection times. Longer withdrawal times may yield similar neoplasia detection rates as found by HD chromoendoscopy. OBJECTIVE: …
Urinary prostaglandin metabolites evaluation for activity monitoring in inflammatory bowel disease
Publication Year: 2025 Source: Sci Rep PMID: 39819996 DOI: 10.1038/s41598-024-78154-3
Inflammatory bowel diseases cause chronic intestinal inflammation, including Crohn's disease (CD) and ulcerative colitis (UC). Prostaglandin E-major urinary metabolite (PGE-MUM) is a urine biomarker for disease activity in IBD. This study evaluated PGE-MUM performance for predicting an active disease in patients with CD and UC. We also compared PGE-MUM performances …
Expression Profile of MicroRNAs in Breast Milk of Women With Inflammatory Bowel Disease: Correlation With Disease Activity and Medical Treatments
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39820274 DOI: 10.1093/ibd/izae290
BACKGROUND: Although most inflammatory bowel disease (IBD) medications are considered safe during pregnancy, their impact on microRNAs (miRNAs) in breast milk is largely unknown. MiRNAs in milk, carried by milk-derived extracellular vesicles (MDEs), are transmitted to the newborn's gut to regulate genes. Aberrant miRNA expression profiles have been found in …
Is routine hearing screening necessary in patients with inflammatory bowel disease - a prospective study
Publication Year: 2025 Source: Eur Arch Otorhinolaryngol PMID: 39820730 DOI: 10.1007/s00405-024-09163-1
PURPOSE: To compare audiological profiling and association of hearing loss in different types of IBD and evaluate the degree of hearing impairment based on duration of illness and age parameters. METHODS: 120 subjects evaluated at a tertiary centre were divided into 2 groups- Controls and Cases. Cases were sub grouped …
Exosomes in Autoimmune Diseases: A Review of Mechanisms and Diagnostic Applications
Publication Year: 2025 Source: Clin Rev Allergy Immunol PMID: 39820756 DOI: 10.1007/s12016-024-09013-2
Exosomes, small extracellular vesicles secreted by various cell types, have emerged as key players in the pathophysiology of autoimmune diseases. These vesicles serve as mediators of intercellular communication, facilitating the transfer of bioactive molecules such as proteins, lipids, and nucleotide. In autoimmune diseases, exosomes have been implicated in modulating immune …
Cannabis use in Crohn's disease: a systematic review and meta-analysis of randomized controlled trials (RCTs)
Publication Year: 2025 Source: Ir J Med Sci PMID: 39821383
OBJECTIVE: This meta-analysis aims to systematically evaluate the efficacy and safety of cannabis in the management of Crohn's disease (CD) by synthesizing evidence from randomized controlled trials (RCTs). By adhering to the 2020 PRISMA guidelines and registering the study protocol with PROSPERO, this research intends to offer robust, evidence-based recommendations …
Anthropometric Trajectories in Children Prior to Development of Inflammatory Bowel Disease
Publication Year: 2025 Source: JAMA Netw Open PMID: 39821394 DOI: 10.1001/jamanetworkopen.2024.55158
IMPORTANCE: Poor nutrition and growth in childhood have short-term and long-term consequences, so understanding the timing of the onset of an impaired nutritional status is crucial for diagnosing and treating inflammatory bowel disease (IBD) at its earliest stage. OBJECTIVE: To assess anthropometric trajectories before a pediatric diagnosis of IBD and …
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