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Selected Use of Complementary and Alternative Medicine (CAM) Agents in IBD
Publication Year: 2025 Source: Curr Gastroenterol Rep PMID: 39821707 DOI: 10.1007/s11894-025-00960-0
PURPOSE OF REVIEW: Inflammatory bowel disease (IBD) can cause significant psychological, physical, and economic burdens on patients and healthcare systems. Studies show over one-fifth of patients will seek nontraditional methods of treatment for managing their symptoms. Understanding the benefits - and potential harms - of these therapies is important to …
Inhibition of chondroitin sulphate-degrading enzyme Chondroitinase ABC by dextran sulphate
Publication Year: 2025 Source: Glycoconj J PMID: 39821876
Chondroitin sulphate (CS) is a sulphated glycosaminoglycan (GAG) polysaccharide found on proteoglycans (CSPGs) in extracellular and pericellular matrices. Chondroitinase ABC (CSase ABC) derived from Proteus vulgaris is an enzyme that has gained attention for the capacity to cleave chondroitin sulphate (CS) glycosaminoglycans (GAG) from various proteoglycans such as Aggrecan, Neurocan, …
Unfolded protein response: An essential element of intestinal homeostasis and a potential therapeutic target for inflammatory bowel disease
Publication Year: 2025 Source: Acta Physiol (Oxf) PMID: 39822064 DOI: 10.1111/apha.14284
Different physiological and pathological situations can produce alterations in the cell's endoplasmic reticulum (ER), leading to a condition known as ER stress, which can trigger an intricate intracellular signal transduction system known as the unfolded protein response (UPR). UPR is primarily tailored to restore proteostasis and ER equilibrium; otherwise, if …
Leucine-rich alpha-2 glycoprotein in combination with C-reactive protein for predicting endoscopic activity in Crohn's disease: a single-centre, cross-sectional study
Publication Year: 2025 Source: Ann Med PMID: 39823192
BACKGROUND AND OBJECTIVE: Leucine-rich alpha-2 glycoprotein (LRG) is a novel biomarker for Crohn's disease (CD). The utility of combination use of LRG and C-reactive protein (CRP) has not been reported. This study aimed to investigate the diagnostic performance of LRG in combination with CRP to predict endoscopic activity. METHODS: A …
LEDGF/p75 promotes transcriptional pausing through preventing SPT5 phosphorylation
Publication Year: 2025 Source: Sci Adv PMID: 39823345 DOI: 10.1126/sciadv.adr2131
SPT5 exhibits versatile functions in RNA Pol II promoter proximal pausing, pause release, and elongation in metazoans. However, the mechanism underlying the functional switch of SPT5 during early elongation has not been fully understood. Here, we report that the phosphorylation site-rich domain (PRD)/CTR1 and the prion-like domain (PLD)/CTR2, which are …
Aspirin after completion of standard adjuvant therapy for colorectal cancer (ASCOLT): an international, multicentre, phase 3, randomised, double-blind, placebo-controlled trial
Publication Year: 2025 Source: Lancet Gastroenterol Hepatol PMID: 39824200
BACKGROUND: Aspirin is a simple, globally available medication that has been shown to reduce the incidence of colorectal cancer. We aimed to evaluate the safety and efficacy of aspirin in the secondary prevention of colorectal cancer. METHODS: This phase 3, randomised, double-blind, placebo-controlled trial was conducted at 66 centres across …
T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice
Publication Year: 2025 Source: Mucosal Immunol PMID: 39824503
Immunoglobulin A (IgA), the most abundantly produced antibody at mucosal surfaces, is thought to play key roles in immune responses to respiratory and enteric pathogens and in the regulation of commensal colonization. Low IgA levels have been associated with recurrent infections and immune dysregulation, including inflammatory bowel disease and autoimmunity. …
Post-colonoscopy cancer rates in Scotland from 2012 to 2018: A population-based cohort study
Publication Year: 2025 Source: Colorectal Dis PMID: 39824785
AIM: The aim of this work was to quantify post-colonoscopy colorectal cancer (PCCRC) rates in National Health Service (NHS) Scotland using World Endoscopy Association guidelines, compare incidence between health boards and referral streams and explore comparisons in results with published data from other healthcare systems. METHOD: This is a population-based …
Systematic review on definitions of intestinal ultrasound treatment response and remission in inflammatory bowel disease
Publication Year: 2025 Source: J Crohns Colitis PMID: 39825748 DOI: 10.1093/ecco-jcc/jjaf011
BACKGROUND: Intestinal ultrasound (IUS) is emerging as a valuable tool to assess treatment response in inflammatory bowel disease (IBD) clinical trials. This study details how IUS defines response and remission to evaluate treatment efficacy in IBD patients. METHODS: We conducted a comprehensive search of studies from 1984 to March 31, …
Assessment and reporting of extraintestinal manifestations and fatigue in phase 3 inflammatory bowel disease clinical trials
Publication Year: 2025 Source: J Crohns Colitis PMID: 39825757 DOI: 10.1093/ecco-jcc/jjaf009
BACKGROUND: Extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) are frequently experienced by patients and may lead to severe symptoms and fatigue. However, the reporting patterns of these outcomes in IBD randomized controlled trials (RCTs) are not clear. METHODS: We searched placebo-controlled phase 3 RCTs of advanced therapies in IBD …
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