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Inter-Rater Disagreements in Applying the Montreal Classification for Crohn's Disease: The Five-Nations Survey Study
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39825768 DOI: 10.1002/ueg2.12757
BACKGROUND: The Montreal classification has been widely used in Crohn's disease since 2005 to categorize patients by the age of onset (A), disease location (L), behavior (B), and upper gastrointestinal tract and perianal involvement. With evolving management paradigms in Crohn's disease, we aimed to assess the performance of gastroenterologists in …
Network Meta-Analysis: Comparison of Endoscopic Dysplasia Detection Technologies in Inflammatory Bowel Disease
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 39825829 DOI: 10.1111/apt.18500
BACKGROUND: Novel colorectal cancer endoscopic surveillance techniques for inflammatory bowel disease (IBD) have recently been developed. AIMS: Compare the efficacy of currently available techniques for dysplasia detection in colonic IBD. METHODS: We conducted a systematic literature search from inception to March 2024 for randomized controlled trials (RCTs) or prospective cohort …
Medical, Endoscopic, and Surgical Treatments for Rectal Cuffitis in IBD Patients with an Ileal Pouch-Anal Anastomosis: A Narrative Review
Publication Year: 2025 Source: Dig Dis Sci PMID: 39826061 DOI: 10.1007/s10620-024-08822-x
BACKGROUND: Ulcerative colitis patients who undergo ileal pouch-anal anastomosis (IPAA) without mucosectomy may develop inflammation of the rectal cuff (cuffitis). Treatment of cuffitis typically includes mesalamine suppositories or corticosteroids, but refractory cuffitis may necessitate advanced therapies or procedural interventions. This review aims to summarize the existing literature regarding treatments options …
Severe obesity, a susceptibility factor for developing inflammatory bowel disease: results of a population-based study
Publication Year: 2025 Source: J Crohns Colitis PMID: 39826088 DOI: 10.1093/ecco-jcc/jjaf010
BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) develops in genetically susceptible individuals exposed to certain environmental factors, of which only a few have been established. We aimed to assess whether bariatric surgery (BS) and severe obesity are associated with an increased risk of developing IBD. METHODS: Adults diagnosed with obesity …
Analytical validation of the IBD segment-based tool KinSNP(®) for human identification applications
Publication Year: 2025 Source: Biotechniques PMID: 39826154 DOI: 10.1080/07366205.2025.2454770
KinSNP((R)) v1.0, a software tool for human identification, has been widely used to measure IBD segment sharing between individuals using dense SNP data. Herein, the tool was validated using simulated pedigree data (up to 9(th) degree relationships) from five diverse populations from the 1000 Genomes Project. Performance was further tested …
NLRP3 promoter methylation as a predictive biomarker for glucocorticoid response in patients with inflammatory bowel disease
Publication Year: 2025 Source: Biomed Pharmacother PMID: 39826354 DOI: 10.1016/j.biopha.2025.117824
Glucocorticoids are used for inflammatory bowel disease (IBD) therapy; however nearly 50 % of IBD patients exhibit resistance or dependence. This study evaluates the relationship between methylation level at two CpG sites (cg21991396 and cg00448525) within NLRP3 promoter and glucocorticoid response of 94 IBD pediatrics (39 with Crohn's disease (40.4 …
Physiological Data Collected From Wearable Devices Identify and Predict Inflammatory Bowel Disease Flares
Publication Year: 2025 Source: Gastroenterology PMID: 39826619 DOI: 10.1053/j.gastro.2024.12.024
BACKGROUND & AIMS: Wearable devices capture physiological signals noninvasively and passively. Many of these parameters have been linked to inflammatory bowel disease (IBD) activity. We evaluated the associative ability of several physiological metrics with IBD flares and how they change before the development of flare. METHODS: Participants throughout the United …
Cumulative experience meets modern science: Remarkable effects of TongXieYaoFang formula on facilitating intestinal mucosal healing and secretory function
Publication Year: 2025 Source: J Ethnopharmacol PMID: 39826789
ETHNOPHARMACOLOGICAL RELEVANCE: TongXieYaoFang (TXYF), a classical formula used in Traditional Chinese Medicine, is renowned for its efficacy in treating chronic abdominal pain and diarrhoea. Modern research suggests that fundamental relief from these symptoms depends on complete intestinal mucosal healing, which normalises gut secretory functions. Consensus between traditional and modern medical …
Sometimes Small Is Beautiful: Discovery of the Janus Kinases (JAK) and Signal Transducer and Activator of Transcription (STAT) Pathways and the Initial Development of JAK Inhibitors for IBD Treatment
Publication Year: 2025 Source: Dig Dis Sci PMID: 39827247 DOI: 10.1007/s10620-024-08791-1
The Janus kinase/signal transducer and activator of transfection (JAK/STAT) system is comprised of multiple cell surface receptors, receptor tyrosine kinases, and signal transducers that are key components of numerous systems involved in malignancy, inflammation, immune surveillance and development, cellular proliferation, metabolism, differentiation, apoptosis, and hematologic disorders, all of which when …
Gut-Derived Ursodeoxycholic Acid from Saponins of Quinoa Regulated Colitis via Inhibiting the TLR4/NF-κB Pathway
Publication Year: 2025 Source: J Agric Food Chem PMID: 39827465 DOI: 10.1021/acs.jafc.4c09151
Alteration of the gut microbiota and its metabolites plays a key role in the development of inflammatory bowel disease (IBD). Here, we investigated the mechanism of saponins, a byproduct from quinoa (SQ) processing, in regulating IBD. SQ ameliorated gut microbiota dysbiosis revealed by 16S rRNA sequencing and improved colonic antioxidant …
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