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Prebiotics empower probiotics with gastrointestinal stress resistance for colon-targeted release to synergistically alleviate colitis
Publication Year: 2025 Source: J Control Release PMID: 39900225
Oral administration of probiotics holds promise for alleviating ulcerative colitis (UC), yet their efficacy is inevitably compromised by the hostile gastrointestinal (GI) environment. Here, we devised a strategy by coating beta-glucan (GN) prebiotic onto the surface of Lactobacillus plantarum (Lp) probiotic at the single-cell level (Lp@CGN) based on bioorthogonal chemistry …
Enabling Targeted Drug Delivery for Treatment of Ulcerative Colitis with Mucosal-Adhesive Photoreactive Hydrogel
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 39900372
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. UC treatments are limited by significant adverse effects associated with non-specific drug delivery, such as systematic inhibition of the host immune system. Endoscopic delivery of a synthetic hydrogel material with biocompatible gelation that can efficiently cover irregular tissue surfaces provides an …
Protective Role of Nano-encapsulated Bifidobacterium breve, Bacilllus coagulans, and Lactobacillus plantarum in Colitis Model: Insights Toward Propagation of Short-Chain Fatty Acids and Reduction of Exaggerated Inflammatory and Oxidative Response
Publication Year: 2025 Source: Probiotics Antimicrob Proteins PMID: 39900879 DOI: 10.1007/s12602-025-10472-y
Irritable bowel disease (IBD), also known as ulcerative colitis and Crohn's disease, is a chronic inflammatory disorder affecting millions of people worldwide. Herein, nano-encapsulated multi-strain probiotics formulation, comprising Bifidobacterium breve DSM24732 and B. coagulans SANK 70258 and L. plantarum DSM24730 (BBLNPs) is used as an effective intervention technique for attenuating …
Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis-A preclinical systematic review and meta-analysis
Publication Year: 2025 Source: BMC Gastroenterol PMID: 39901089
BACKGROUND: Ulcerative colitis (UC) is a type of inflammatory bowel disease, and current treatments often fall short, necessitating new therapeutic options. Baicalin shows therapeutic promise in UC animal models, but a systematic review is needed. METHODS: A systematic search was conducted across databases including PubMed, EBSCO, Web of Science, and …
Zebrafish as a model for human epithelial pathology
Publication Year: 2025 Source: Lab Anim Res PMID: 39901304
Zebrafish (Danio rerio) have emerged as an influential model for studying human epithelial pathology, particularly because of their genetic similarity to humans and their unique physiological traits. This review explores the structural and functional homology between zebrafish and human epithelial tissues in organs, such as the gastrointestinal system, liver, and …
Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis
Publication Year: 2025 Source: Dialogues Clin Neurosci PMID: 39901313 DOI: 10.1080/19585969.2025.2460798
BACKGROUND: Emerging observational studies have indicated the association between autism spectrum disorder (ASD) and IBD, including Crohn's disease (CD) and ulcerative colitis (UC), whereas the causality remains unknown. METHODS: Summary-level data from large-scale genome-wide association (GWAS) studies of IBD and ASD were retrieved. Mendelian randomisation analyses were performed with a …
A phlorotannin nanoparticle-hydrogel composite for enhanced oral delivery and treatment of ulcerative colitis
Publication Year: 2025 Source: J Mater Chem B PMID: 39901663
Designing innovative strategies for oral delivery of active compounds is particularly promising for the treatment of intestinal diseases such as ulcerative colitis (UC). However, obstacles like poor therapeutic efficacy, low bioavailability, and limited biocompatibility need to be addressed. Here, via the Schiff base reaction, we developed nanoparticles based on PT …
Nonconventional dysplasia in patients with inflammatory bowel disease and colorectal adenocarcinoma: a case-cohort study
Publication Year: 2025 Source: J Crohns Colitis PMID: 39901738 DOI: 10.1093/ecco-jcc/jjaf022
BACKGROUND AND AIMS: Patients with inflammatory bowel disease (IBD) face increased risk of colorectal cancer (CRC). While the natural history of conventional dysplastic precursor lesions has been well-studied, the neoplastic potential of recently described nonconventional (NC) IBD-associated colonic mucosal lesions is unclear. We aimed to assess the incidence of antecedent …
Assessment of activity and severity of inflammatory bowel disease in cross-sectional imaging techniques: a systematic review
Publication Year: 2025 Source: J Crohns Colitis PMID: 39901740 DOI: 10.1093/ecco-jcc/jjaf023
BACKGROUND AND AIMS: Cross-sectional imaging techniques, including intestinal ultrasonography (IUS), computed tomography enterography (CTE), magnetic resonance enterography (MRE), are increasingly used for the evaluation of inflammatory bowel diseases (IBD). We aimed to systematically review literature evidence on the assessment of disease activity, and/or severity through cross-sectional imaging in IBD patients, …
Antinuclear antibodies staining patterns and titres in juvenile idiopathic arthritis
Publication Year: 2025 Source: Mod Rheumatol PMID: 39901832
OBJECTIVES: In our study, we evaluated the antinuclear antibodies (ANA) staining patterns and titres in juvenile idiopathic arthritis (JIA) patients. METHODS: JIA patients were retrospectively assessed. ANA was identified by using indirect immunofluorescence assay on HEp-2 cells, with a positivity threshold set at a titre of >/=1/100. RESULTS: Eight hundred-five …
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