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Wearable Devices Identify Altered Sleep Characteristics and Sleep Trajectories in Active Inflammatory Bowel Disease
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40581072 DOI: 10.1016/j.cgh.2025.06.003
BACKGROUND AND AIMS: Poor sleep is associated with flares of inflammatory bowel disease (IBD). Studies often rely on subjective assessments of sleep and disease activity. Our aim is to use wearable devices to objectively assess the impact of inflammation and symptoms on sleep architecture in IBD. METHODS: Individuals >/=18 years …
Enteroendocrine cell differentiation: Implications for human disease
Publication Year: 2025 Source: Mol Cell Endocrinol PMID: 40581205
Enteroendocrine cells are the most abundant hormone producing cells in humans. Though they make up less than 1 % of the gastrointestinal epithelium, these cells have a large physiological impact through the secretion of hormones that act both locally and systemically to regulate intestinal function and whole-body metabolism, among other …
Not All Cuts Heal the Same: Elevated Anastomotic Leak Rates after Elective Colectomy for IBD and Diverticulitis
Publication Year: 2025 Source: J Gastrointest Surg PMID: 40581319 DOI: 10.1016/j.gassur.2025.102138
BACKGROUND: Anastomotic leak is a severe complication of colorectal surgery. The association of anastomotic leak with indication for surgery remains unclear. This study aims to assess the risk of anastomotic leak among patients undergoing elective colectomy for inflammatory bowel disease, cancer, diverticulitis, and polyp, hypothesizing the highest risk in inflammatory …
Endo-Histo foundational fusion model: a novel artificial intelligence for assessing histologic remission and response to therapy in ulcerative colitis clinical trial
Publication Year: 2025 Source: J Crohns Colitis PMID: 40581339
BACKGROUND AND AIMS: Artificial intelligence (AI)-enabled endoscopy and histology offer accurate, objective, and rapid assessment of disease activity in ulcerative colitis (UC). Emerging multi-source AI models may enhance standardized disease evaluation and outcome prediction. This investigation aimed to develop a novel AI model fusing endoscopic and histologic features to improve …
Population Pharmacokinetics Model of Thioguanine in Patients with Inflammatory Bowel Disease
Publication Year: 2025 Source: Clin Pharmacokinet PMID: 40581725 DOI: 10.1007/s40262-025-01532-1
BACKGROUND: Thioguanine (TG) has recently been rediscovered as an immunosuppressive agent in the treatment of inflammatory bowel disease (IBD). This prodrug is directly converted into its active metabolites, 6-thioguanine nucleotides (6-TGNs), targeting the inhibition of RAC1 GTPase in inflammatory conditions, disrupting key cellular signaling pathways necessary for T-cell activation and …
Prevalence and Predictors of Symptoms of Anxiety or Depression at Diagnosis in Patients With Inflammatory Bowel Disease: An Inception Cohort
Publication Year: 2025 Source: Aliment Pharmacol Ther PMID: 40581905 DOI: 10.1111/apt.70248
BACKGROUND: The prevalence of symptoms of a common mental disorder, including anxiety or depression, is high among patients with established inflammatory bowel disease (IBD). This may represent a therapeutic target for affected patients. However, whether these symptoms arise from genuine gut-brain effects, or are merely a consequence of a preceding …
Identification of novel biomarkers linked to M1 macrophage infiltration in the diagnosis of inflammatory bowel diseases
Publication Year: 2025 Source: Int Immunopharmacol PMID: 40582145 DOI: 10.1016/j.intimp.2025.115138
Inflammatory bowel disease (IBD) often lacks a definitive diagnostic standard, leading to diagnoses through exclusion. This study aimed to create a predictive model for IBD using bioinformatics and deep learning while identifying potential biomarkers to improve management outcomes. Analyses indicated that differentially expressed genes in IBD patients were associated with …
Parishin from Gastrodia elata ameliorates DSS induced colitis and anxiety-like behavior in mice by regulating intestinal barrier function and microviota-gut-brain axis
Publication Year: 2025 Source: Phytomedicine PMID: 40582206 DOI: 10.1016/j.phymed.2025.157019
BACKGROUND: Inflammatory bowel diseases (IBDs), including colitis, are commonly associated with dysfunctional intestinal barriers and dysregulated gut microbiota. Moreover, current medications for IBD cause serious side effects with prolonged use. Parishin, a phenolic glucoside isolated from Gastrodia elata, is known for its medicinal value in anti-aging properties. However, the therapeutic …
Ellagic acid-imbedded MoO(3) nanowires architecture: External mediator-less electrochemical immunoprobing of inflammatory bowel disease marker
Publication Year: 2025 Source: Biosens Bioelectron PMID: 40582302 DOI: 10.1016/j.bios.2025.117719
Oxidative stress biomarkers such as 8-iso-prostaglandin F(2alpha) (8-iso-PGF2alpha) dictate a central dogma of clinically prevalent (non) communicable diseases such as inflammatory bowel disease (IBD) but are less explored owing to the complexity, sensitivity, and selectivity of conventional detecting methods. Thus, there is an urgent need for a rapid, simple, and …
Wearable technologies in inflammatory bowel disease: A scoping review
Publication Year: 2025 Source: Clin Gastroenterol Hepatol PMID: 40582389 DOI: 10.1016/j.cgh.2025.06.013
BACKGROUND AND AIMS: Use of wearable technologies is increasing and may offer potential benefits in collecting actionable health data. We performed a scoping review on the use of wearable technologies in patients with inflammatory bowel disease (IBD). METHODS: The PubMed, Embase, and Scopus databases were searched till Feb 7, 2025, …
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