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Impact of inflammatory bowel disease on perioperative complications in patients undergoing cervical spine fusion
Publication Year: 2025 Source: World Neurosurg PMID: 40582505 DOI: 10.1016/j.wneu.2025.124210
OBJECTIVE: The global prevalence of inflammatory bowel disease (IBD) is increasing rapidly, and its systemic inflammation and immune dysregulation may affect surgical outcomes. However, the impact of IBD on perioperative complications in cervical spine fusion has never been reported. This study aimed to investigate the association between IBD and perioperative …
A novel link driving immune cell-fibroblast interactions in intestinal fibrosis
Publication Year: 2025 Source: Mucosal Immunol PMID: 40582571
No Abstract
Celastrol Alleviates Intestinal Epithelial Permeability by Inhibiting Ferroptosis through PI3K/Akt/FOXO1/HO-1 Signaling Pathway
Publication Year: 2025 Source: Am J Chin Med PMID: 40582719
Ulcerative colitis (UC) is a recurrent inflammatory intestinal disorder characterized by systemic inflammatory response, abnormal intestinal epithelial cell death, and damage to the intestinal mucosal barrier. This study aimed to explore the role of celastrol in ferroptosis and intestinal epithelial barrier permeability. The results demonstrated that celastrol significantly inhibited ferroptosis …
Transperineal Ultrasound Enhance Accuracy of Bowel Ultrasound in Assessing Disease Activity in Pediatric Ulcerative Colitis Patients
Publication Year: 2025 Source: Ultrasound Med Biol PMID: 40582895
OBJECTIVE: Ulcerative colitis (UC) is an inflammatory bowel disease involving the rectum and colon. Transabdominal bowel ultrasound (TBUS) is a noninvasive technique evaluating inflamed colonic segments. Previous studies showed optimal concordance between TBUS and endoscopy in the colon, but suboptimal in the rectum. Transperineal ultrasound (TPUS) of the rectum achieved …
Anti-Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile
Publication Year: 2025 Source: Adv Sci (Weinh) PMID: 40583166
Ulcerative colitis (UC) is a complex inflammatory bowel disease characterized by multiple factors. Alleviating inflammation is the primary therapeutic approach. However, currently employed anti-inflammatory treatments have limited efficacy and cause side effects. Safer, more effective therapies are needed. Selenium nanosheets (SeNSs) are biocompatible, anti-inflammatory, and low-toxicity nanomaterials with high surface …
Application of zein nanoparticles for the treatment of inflammatory bowel diseases
Publication Year: 2025 Source: Expert Opin Drug Deliv PMID: 40583279 DOI: 10.1080/17425247.2025.2527693
INTRODUCTION: Inflammatory bowel diseases (IBD) are chronic gastrointestinal disorders with rising global incidence. Current therapies often suffer from systemic side effects, limited efficacy, and poor patient compliance, particularly with injectable formulations. These limitations underscore the need for innovative oral delivery strategies capable of targeted action in the inflamed intestine. AREAS …
The importance of patient-reported outcomes: A call for their integration in the routine care of patients with multiple sclerosis
Publication Year: 2025 Source: Mult Scler PMID: 40583354
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Common symptoms include physical disability, cognitive impairment, spasticity, fatigue, bowel/bladder dysfunction and depression. The use of patient-reported outcomes (PROs) can be used to systematically assess the burden of the disease and its impact on treatment and health-related …
Fecal Microbial Community Profiling Allows Discrimination of Phenweotype and Treatment Response in Pediatric Crohn's Disease and Ulcerative Colitis-An International Meta-Analysis
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40583454 DOI: 10.1093/ibd/izaf135
BACKGROUND AND AIMS: The pathophysiology of pediatric inflammatory bowel disease (PIBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is not entirely understood. Dysregulation of the intestinal microbiome is recognized as both a disease-driving and a potential therapeutic target. This study aimed to systematically analyze gut microbiome compositions and its …
Unraveling Genetic Versus Environmental Factors Determining Disease Course in Inflammatory Bowel Diseases: A Population-Based Cohort Study in First- and Second-Generation Immigrants
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 40583456 DOI: 10.1093/ibd/izaf128
BACKGROUND: Inflammatory bowel diseases (IBD) incidence in immigrants approximates that of the host country in progressive generations but less is known about their disease outcome. We investigate how the immigrant generation affects IBD outcomes. METHODS: In this population-based cohort study, the risks of first IBD-related hospitalization, first IBD-related surgery, need …
Ulcerative colitis disease severity affects the speed of symptom relief under filgotinib treatment: a post hoc analysis of the phase 2b/3 SELECTION study
Publication Year: 2025 Source: Intest Res PMID: 40583491
BACKGROUND/AIMS: Filgotinib is an oral, once-daily, Janus kinase 1 preferential inhibitor approved for the treatment of ulcerative colitis (UC). This study aimed to assess symptomatic response with filgotinib 200 mg (FIL200) according to disease severity using baseline partial Mayo Clinic Score (pMCS). METHODS: In the phase 2b/3 SELECTION study (NCT02914522), …
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