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The role of colonic microbiota amino acid metabolism in gut health regulation
Publication Year: 2025 Source: Cell Insight PMID: 39926315
The human gut microbiota plays a critical role in maintaining host homeostasis through metabolic activities. Among these, amino acid (AA) metabolism by the microbiota in the large intestine is highly heterogeneous and relevant to host health. Despite increasing interest, microbial AA metabolism remains relatively unexplored. This review highlights recent advances …
Comparative analysis of enteroscopy, computed tomography enterography, and intestinal ultrasound for the evaluation of small bowel Crohn's disease
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39926319
BACKGROUND: The comparable evaluation of computed tomography enterography (CTE), enteroscopy, and intestinal ultrasound in small bowel Crohn's disease (CD) is imprecise. OBJECTIVES: The purpose of this study was to analyze the findings of enteroscopy, CTE, and intestinal ultrasound to determine the advantages and disadvantages of each method for the evaluation …
Studies on the alleviating effect of Bifidobacterium lactis V9 on dextran sodium sulfate-induced colitis in mice
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 39926427 DOI: 10.3389/fmed.2025.1496023
BACKGROUND: Inflammatory bowel disease (IBD) has become a global public health problem with complex pathogenesis and limited therapeutic options. We aimed to investigate the potential mechanisms by which Bifidobacterium lactis V9 (V9) alleviated colitis in a dextran sodium sulfate-induced colitis model mice. METHODS: Mice were induced to develop colitis by …
Do Antibiotics Cause Inflammatory Bowel Disease? A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Visc Med PMID: 39927188 DOI: 10.1159/000541601
INTRODUCTION: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), exhibits a multifactorial pathogenesis influenced by genetic and environmental factors. Antibiotic usage has been implicated in modifying the gut microbiome, potentially leading to dysbiosis and contributing to IBD risk. Despite existing literature, the relationship remains inconclusive. This …
Epidemiology of colorectal cancer: A review with special emphasis on India
Publication Year: 2025 Source: Indian J Gastroenterol PMID: 39928255 DOI: 10.1007/s12664-024-01726-8
Colorectal cancer (CRC) is a common malignancy and cause for death around the world. In India, it ranks as the fourth most incident cancer in both sexes, with 64,863 cases and 38,367 deaths in 2022. With such high mortality, CRC survival in India is way lesser than that of developed …
Association Between Intestinal Diseases and Periodontitis: A Systematic Review and Meta-Analysis
Publication Year: 2025 Source: Oral Dis PMID: 39928298 DOI: 10.1111/odi.15260
BACKGROUND: Despite evidence suggesting a potential correlation between intestinal diseases such as inflammatory bowel diseases (IBD) and colorectal cancer (CRC) with periodontitis (PD), there is a lack of comprehensive systematic reviews and meta-analyses to consolidate these findings. METHODS: This study investigates studies published until December 31, 2023, in reputable databases …
A Novel Surgical Technique for Transsphincteric Anal Fistulas: A Comparison Between the Modified Submucosal Ligation of Fistula Tract (MSLOFT) and the Hybrid Seton Techiniques - A Propensity Score Matching Analysis
Publication Year: 2025 Source: Surg Innov PMID: 39928847
BackgroundThis study aimed to compare the outcomes of a modified submucosal ligation of the fistula tract (MSLOFT) technique with the hybrid seton technique for treating transsphincteric anal fistulas.Material and MethodsA retrospective analysis was conducted with ethical approval from Baskent University. Patients over 18 years of age with a diagnosis of …
The Lived Experience of Adults With Inflammatory Bowel Disease in Rural Areas: Phenomenological Study
Publication Year: 2025 Source: Nurs Health Sci PMID: 39928987 DOI: 10.1111/nhs.70058
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic gastrointestinal condition with a multifactorial etiology. It significantly impacts patients' quality of life, particularly, in rural areas where access to specialized care is limited. Challenges such as increased travel costs, social isolation, and restricted healthcare access are …
Eight Cases of Pediatric Acute-Onset Neuropsychiatric Syndrome with Inflammatory Bowel Disease: Immunologic Intersections
Publication Year: 2025 Source: Dev Neurosci PMID: 39929162 DOI: 10.1159/000543969
INTRODUCTION: Pediatric acute-onset neuropsychiatric syndrome (PANS) is an immune-mediated disease characterized by abrupt onset neurobehavioral changes. Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn's disease (CD), chronic conditions characterized by gastrointestinal inflammation. We describe eight individuals with both PANS and IBD. METHODS: All individuals with both IBD and …
Durable remission after ileocolic resection for Crohn's disease is achievable in selected patients. Long-term results of a prospective multicentric cohort study of the GETAID Chirurgie
Publication Year: 2025 Source: J Crohns Colitis PMID: 39774666
BACKGROUND AND AIMS: Postoperative recurrence requiring medical treatment intensification or redo surgery is common after ileocolic resection (ICR) for Crohn's disease (CD). This study aimed to identify a subgroup of CD patients for whom ICR could achieve durable remission. METHODS: This retrospective follow-up study analyzed 592 CD patients who underwent …
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