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[Inflammatory bowel diseases in children and adolescents : An overview with particular attention to genetic testing]
Publication Year: 2025 Source: Inn Med (Heidelb) PMID: 39774688 DOI: 10.1007/s00108-024-01827-8
Pediatric-onset inflammatory bowel disease (PIBD) is increasingly recognized in Germany. Patients with PIBD often present with more extensive and active disease. Clinical suspicion of IBD requires early initiation of the diagnostic work-up (e.g., non-invasive fecal marker for inflammation) and referral to a pediatric gastroenterology center. In the presence of very …
The Correlation Between Fecal Amino Acids, Colonic Mucosal Taste Receptors, and Clinical Features and Indicators of Ulcerative Colitis: A Multicenter Exploratory Study
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39774769
BACKGROUND: Patients with ulcerative colitis (UC) exhibit abnormal amino acid (AA) metabolism. Taste receptors play a crucial role in the detection of intestinal AAs. Nevertheless, it remains unclear whether UC patients exhibit abnormal expression of these receptors in the colon. METHODS: An observational, multicenter study was conducted involving adult patients …
Intestinal tissue levels of anti-TNF alpha, antibodies, and cytokines in paediatric Crohn disease
Publication Year: 2025 Source: Sci Rep PMID: 39775097
The aim was to explore factors associated with intestinal tissue levels of anti-TNF alpha (anti-TNF), anti-TNF antibodies, and cytokines in pediatric patients with Crohn Disease (CD). In a prospective exploratory study of CD patients undergoing ileocecal resection or colonoscopy between 6/2020 and 1/2023, we analysed tissue levels of anti-TNF, anti-TNF …
Ellagic acid alleviates DSS-induced ulcerative colitis by inhibiting ROS/NLRP3 pathway activation and modulating gut microbiota in mice
Publication Year: 2025 Source: Eur J Nutr PMID: 39775279
Ulcerative colitis (UC) can cause severe oxidative stress in the colon, which can lead to tissue damage and an imbalance in the normal gut microbiota. Ellagic acid (EA) is one of the main types of plant polyphenols with improved pharmacological effects such as antioxidant, anti-inflammatory, and antibacterial properties. However, currently, …
Morbidity in males with 45,X/46,XY resembles the morbidity pattern in Turner syndrome: a national population-based study
Publication Year: 2025 Source: J Clin Endocrinol Metab PMID: 39775857
No Abstract
Psychiatric comorbidities, inflammatory bowel disease, and urticaria in acne vulgaris patients undergoing isotretinoin treatment: a multicenter cohort study from the TriNetX database
Publication Year: 2025 Source: Arch Dermatol Res PMID: 39775941
No Abstract
Factors associated with therapeutic response to adalimumab in hidradenitis suppurativa: evidence from the Belgian patients of the European Registry for Hidradenitis Suppurativa (ERHS-Be)
Publication Year: 2025 Source: Arch Dermatol Res PMID: 39775946
Hidradenitis suppurativa is an inflammatory skin disease for which adalimumab is an effective treatment in just over half of cases. Few factors associated with therapeutic response, and therefore potentially predictive of response, are known to date. This real-life study retrospectively explores the existence of such factors in a Belgian cohort …
Impact of biologics on stoma creation and reversal in Crohn's disease: a retrospective analysis from 2007 to 2021
Publication Year: 2025 Source: Tech Coloproctol PMID: 39775956
BACKGROUND: Trends of stoma creation at index surgery for Crohn's disease (CD) in the biologics era has not been thoroughly investigated. This study aimed to assess the impact of increasing biologics use on stoma rates at index surgery of CD, as well as identifying risk factors for the creation and …
Comparing magnetic resonance enterography and endoscopy findings to the motility of magnetic resonance imaging in pediatric Crohn's disease
Publication Year: 2025 Source: Pediatr Radiol PMID: 39776210
BACKGROUND: Quantitative magnetic resonance imaging (MRI) can evaluate bowel motility in children with Crohn's disease. As inflammation increases, motility decreases. OBJECTIVE: Our aim was to show that quantitative MRI correlates with magnetic resonance enterography (MRE). We hypothesize that the motility score will inversely correlate with the Endoscopic Biopsy Acute Histologic …
Leishmaniasis in Patients With Inflammatory Bowel Disease: A National Multicenter Study of GETECCU
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39776301 DOI: 10.1002/ueg2.12740
BACKGROUND: Leishmaniasis (LI) is a vector-borne illness caused by a protozoan of the genus Leishmania. Data on the features of LI in patients with inflammatory bowel disease (IBD) are scarce. AIM: To describe the characteristics of patients with IBD who present with leishmaniasis, infection outcomes and the risk factors associated …
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