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Intensified and Accelerated Rescue Infliximab Therapy for Acute Severe Ulcerative Colitis in Pregnancy: A Case Report
Publication Year: 2025 Source: JGH Open PMID: 39776619
Acute severe ulcerative colitis (ASUC) in pregnancy poses a clinical challenge with significant risk to both mother and fetus. Anti-TNF alpha therapy is known to be safe in pregnancy, however, data surrounding outcomes in ASUC is limited. In this report, we present the case of a pregnant patient of 10 …
Drug repositioning of mesalamine via supramolecular nanoassembly for the treatment of drug-induced acute liver failure
Publication Year: 2025 Source: Theranostics PMID: 39776792 DOI: 10.7150/thno.101358
Rationale: Acute liver failure (ALF) is characterized by rapid hepatic dysfunction, primarily caused by drug-induced hepatotoxicity. Due to the lack of satisfactory treatment options, ALF remains a fatal clinical disease, representing a grand challenge in global health. Methods: For the drug repositioning to ALF of mesalamine, which is clinically approved …
A Standardized Approach to Transition Improves Care of Young Adults with Inflammatory Bowel Disease
Publication Year: 2025 Source: Pediatr Qual Saf PMID: 39776952 DOI: 10.1097/pq9.0000000000000786
INTRODUCTION: Young adults with inflammatory bowel disease (IBD) are at the risk of poor outcomes when transferring to adult providers. We aimed to increase the percentage of patients with 14-17 years of age undergoing the transition of care and the percentage of patients 18-21 years of age initiating the transfer …
Hepatobiliary and pancreatic manifestations in inflammatory bowel disease: an umbrella review of meta-analyses
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 39777137 DOI: 10.1177/17562848241311165
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), can affect the hepatobiliary system and pancreas, substantially impacting the life quality of patients. OBJECTIVES: To evaluate the quality of evidence and comprehensively assess the validity of associations of IBD with hepatobiliary and pancreatic diseases. DESIGN: We …
Creeping fat and gut microbiota in Crohn's disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 39777251
In this article, we explored the role of adipose tissue, especially mesenteric adipose tissue and creeping fat, and its association with the gut microbiota in the pathophysiology and progression of Crohn's disease (CD). CD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract, influenced …
Diagnosing Crohn's disease in presumed cryptoglandular perianal fistulas: an expert Delphi consensus on early identification of patients at risk of Crohn's disease in perianal fistulas (PREFAB)
Publication Year: 2025 Source: J Crohns Colitis PMID: 39777453
BACKGROUND: The aim of this Delphi study was to reach consensus on a new clinical decision tool to help identify or exclude Crohn's disease (CD) in patients with perianal fistula(s) (PAF). METHODS: A panel of international experts in the field of proctology/inflammatory bowel disease was invited to participate. In the …
Leishmaniasis in IBD Patients: Challenges of a Rare Opportunistic Disease
Publication Year: 2025 Source: United European Gastroenterol J PMID: 39778008 DOI: 10.1002/ueg2.12753
No Abstract
Estimating evolutionary and demographic parameters via ARG-derived IBD
Publication Year: 2025 Source: PLoS Genet PMID: 39778081 DOI: 10.1371/journal.pgen.1011537
Inference of evolutionary and demographic parameters from a sample of genome sequences often proceeds by first inferring identical-by-descent (IBD) genome segments. By exploiting efficient data encoding based on the ancestral recombination graph (ARG), we obtain three major advantages over current approaches: (i) no need to impose a length threshold on …
Postpartum Wound Healing for Mothers with Inflammatory Bowel Disease: Cause for Worry? Insights from the Pregnancy in Inflammatory Bowel Disease and Neonatal Outcomes Registry
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39778154
No Abstract
Custom-made fenestrated Anaconda™ leg extension internal iliac artery aneurysm: A case report
Publication Year: 2025 Source: Int J Surg Case Rep PMID: 39778500 DOI: 10.1016/j.ijscr.2024.110790
INTRODUCTION AND IMPORTANCE: Internal iliac artery aneurysms repair represents a life-threatening condition due to their anatomical position and the risk of rupture. Iliac branch devices are strongly recommended for anatomically suitable patients, but limited alternatives exist when their use is unsuitable. The use of custom-made fenestrated endografts is well documented …
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