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Is stapled Kono-S anastomosis a protective factor against postoperative endoscopic recurrence in Crohn disease? A single-center, retrospective cohort study
Publication Year: 2025 Source: J Gastrointest Surg PMID: 39778702
BACKGROUND: Handsewn Kono-S anastomosis is safe and associated with a reduction in postoperative recurrence (POR) in Crohn disease (CD). This study aimed to investigate the advantages of stapled Kono-S anastomosis in patients with CD who underwent intestinal anastomosis. METHODS: Patients with CD who underwent intestinal anastomosis were reviewed via a …
Vitamin D receptor regulates methyltransferase like 14 to mitigate colitis-associated colorectal cancer
Publication Year: 2025 Source: J Genet Genomics PMID: 39778713
Colitis-associated colorectal cancer (CAC), a serious complication of ulcerative colitis (UC), is associated with a poor prognosis. The vitamin D receptor (VDR) is recognized for its protective role in UC and CAC through the maintenance of intestinal barrier integrity and the regulation of inflammation. This study demonstrates a significant reduction …
Effect of a single rectal fecal microbiota transplantation on clinical severity and fecal microbial communities in dogs with chronic inflammatory enteropathy
Publication Year: 2025 Source: J Vet Intern Med PMID: 39778887
BACKGROUND: Fecal microbiota transplantation (FMT) has been advocated as a treatment for chronic enteropathy (CE) in dogs. However, so far only short-term clinical effects have been reported whereas the effect on the microbiota remains unexplored. HYPOTHESIS/OBJECTIVES: Assess if a single FMT enema can lead to clinical improvement in dogs with …
Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis
Publication Year: 2025 Source: BMJ Open Gastroenterol PMID: 39778975
OBJECTIVE: Etrasimod is an oral, once-daily, selective sphingosine 1-phosphate (S1P)(1,4,5) receptor modulator for the treatment of moderately to severely active ulcerative colitis (UC). S1P(1) receptor expression on cardiac cells is involved in cardiac conduction. We report cardiovascular treatment-emergent adverse events (TEAEs) associated with S1P receptor modulators and other cardiovascular events …
Accelerating repair of infected bone defects through post-reinforced injectable hydrogel mediated antibacterial/immunoregulatory microenvironment at bone-hydrogel interface
Publication Year: 2025 Source: Carbohydr Polym PMID: 39779005 DOI: 10.1016/j.carbpol.2024.123082
Functional injectable hydrogel (IH) is promising for infected bone defects (IBDs) repair, but how to endow it with desired antibacterial/immunoregulatory functions as well as avoid mechanical failures during its manipulation has posed as main challenges. Herein, rosmarinic acid (RosA), a natural product with antibacterial/immunoregulatory activities, was utilized to develop a …
Tailored strategies based on polysaccharide structural and functional properties for nutrients delivery in inflammatory bowel disease
Publication Year: 2025 Source: Carbohydr Polym PMID: 39779033
No Abstract
Eurotium-Cristatum fermented black tea alleviates ulcerative colitis through the PPARγ-NF-κB signaling axis
Publication Year: 2025 Source: Food Res Int PMID: 39779091
No Abstract
Hepatobiliary manifestations of inflammatory bowel disease in Saudi Arabia: A retrospective analysis
Publication Year: 2025 Source: Saudi Med J PMID: 39779365 DOI: 10.15537/smj.2025.46.1.20240758
OBJECTIVES: To evaluate the features and frequency of hepatobiliary diseases in individuals with Inflammatory bowel disease (IBD). METHODS: This retrospective study included all IBD patients at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. The primary focus was on the prevalence of hepatobiliary diseases, such as primary sclerosing cholangitis (PSC), …
Wound Healing After Vaginal Delivery, Episiotomy, and Cesarean Section Delivery Among Women With IBD: Results From the PIANO Registry
Publication Year: 2025 Source: Inflamm Bowel Dis PMID: 39779464 DOI: 10.1093/ibd/izae310
BACKGROUND: Women with inflammatory bowel disease (IBD) face complexities of disease management during pregnancy and childbirth. Apprehension regarding vaginal delivery in pregnant individuals with IBD persists due to concern for perianal disease and perineal trauma. The incidence of poor wound healing after obstetric anal sphincter injury is approximately 4% in …
Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy - active Phytochemicals and In Vivo Molecular Targets
Publication Year: 2025 Source: Pharm Res PMID: 39779619
Angelica gigas Nakai (AGN) root is a medicinal herbal widely used in traditional medicine in Korea. AGN root ethanolic extracts have been marketed as dietary supplements in the United States for memory health and pain management. We have recently reviewed the pharmacokinetics (PK) and first-pass hepatic metabolism of ingested AGN …
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