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[Analysis of nutritional status before and after different induction therapies in children with Crohn's disease]
Publication Year: 2025 Source: Zhongguo Dang Dai Er Ke Za Zhi PMID: 40583710
OBJECTIVES: To study the impact of different induction remission therapies on the nutritional status of children with Crohn's disease (CD). METHODS: A retrospective analysis was conducted on the medical data of 188 children with CD who received induction remission therapy at the Children's Hospital, Zhejiang University School of Medicine from …
Unmasking Amoebiasis: An Unexpected Cause of Colitis in a Non-endemic Region
Publication Year: 2025 Source: Cureus PMID: 40583926 DOI: 10.7759/cureus.86877
Amoebic colitis is a common mimic of inflammatory bowel disease (IBD), primarily encountered in developing countries. We present a case of a 73-year-old British male with no travel history to any amoebic endemic regions, who presented with a three-month history of per rectal (PR) bleeding, diarrhoea, and a positive faecal …
Capsule Endoscopy in Inflammatory Bowel Disease: Current Status and Issues in Clinical Practice
Publication Year: 2025 Source: DEN Open PMID: 40584175
Inflammatory bowel diseases include Crohn's disease (CD) and ulcerative colitis (UC), both of which require endoscopic evaluation of mucosal surfaces. Capsule endoscopy has been used in clinical practice since 2000 as a minimally invasive means of mucosal evaluation. In Japan, there is an innovative algorithm that incorporates capsule endoscopy into …
Risk factors for recurrence of primary sclerosing cholangitis in pediatric liver transplant recipients: A meta-analysis
Publication Year: 2025 Source: World J Gastrointest Surg PMID: 40584471 DOI: 10.4240/wjgs.v17.i6.103867
BACKGROUND: Primary sclerosing cholangitis (PSC) is a long-term liver condition defined by the inflammation and scarring of the bile ducts, resulting in complications such as liver cirrhosis, portal hypertension, and cholangiocarcinoma. Although PSC predominantly affects adults, the incidence in pediatric patients is rising. For individuals in the advanced stages of …
Perioperative nutritional support in patients undergoing gastrointestinal surgery: Current views with an emphasis on prehabilitation efforts
Publication Year: 2025 Source: World J Gastrointest Surg PMID: 40584482
Continuously increasing reports in the international medical literature, along with current guidelines from international societies, support the view that perioperative enteral nutrition (EN) and immunonutrition offer significant benefits to patients with benign and/or malignant digestive disorders, including reduction of postoperative infections and hospital stay. A vital component of the rehabilitation …
Comprehensive proteomic profiling of intestinal tissues in patients with ulcerative colitis
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40584708
INTRODUCTION: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by persistent inflammation of the colonic mucosa. This condition can significantly affect the quality of life of those affected. While UC is common, its underlying mechanisms are not yet fully understood, highlighting the need for a comprehensive proteomic analysis …
An integrated machine learning framework for developing and validating diagnostic models and drug predictions based on ulcerative colitis genes
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40584713
Ulcerative colitis (UC) is a long-lasting inflammatory bowel disease that causes inflammation in the intestines and triggers autoimmune responses. This study aims to identify immune-related biomarkers for ulcerative colitis (UC) and explore potential therapeutic targets. First, we downloaded the expression profiles of datasets GSE87466, GSE87473, and GSE92415 from the GEO …
Gut microbiota from voluntary exercised mice protects the intestinal barrier by inhibiting neutrophil extracellular trap formation
Publication Year: 2025 Source: iScience PMID: 40585508
Ulcerative colitis is an inflammatory bowel disease characterized by impaired intestinal barrier function, dysregulated immune responses, and alterations in the gut microbiota. Excessive formation of neutrophil extracellular traps (NETs), driven by peptidyl arginine deiminase 4 (PAD4) activity, contributes to inflammation modulated by the gut microbiota. In this study, we used …
Increased Risk of Post-Acute Sequalae of COVID-19 in Patients With Immune-Mediated Inflammatory Diseases
Publication Year: 2025 Source: Gastro Hep Adv PMID: 40585901 DOI: 10.1016/j.gastha.2025.100699
BACKGROUND AND AIMS: Dysregulation of the immune system and chronic inflammation, the primary drivers of post-acute sequalae of corona virus disease 2019 (COVID-19) (PASC), are at the heart of immune-mediated inflammatory disease (IMID) pathology. As PASC remains underexplored in IMID patients, we explored the risk of PASC in patients with …
A novel case of aripiprazole and clomipramine-induced toxic megacolon: enough to drive anyone mad
Publication Year: 2025 Source: J Surg Case Rep PMID: 40585916
Toxic megacolon is a potentially lethal disease process in which there is a non-mechanical dilation of the colon to >6 cm, often associated with systemic effects including leukocytosis or hemodynamic compromise. Here, we present a case of a 49-year-old male who presented with idiopathic toxic megacolon who underwent a subtotal …
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